Abstract
The cytotoxic drug, cisplatin (cis-PtCl(2)(NH(3))(2)), has been added to cultures of the marine macroalga, Ulva lactuca, under various experimental conditions. Both accumulation and internalisation over a 48 h period was greater when cisplatin was added to coastal sea water (salinity = 33) from a distilled water solution than when added to either sea water or estuarine water (salinity = 16.5) from a saline solution. This effect is attributed to the greater abundance of the more reactive monoaqua complex (cis-PtCl(OH(2))(NH(3))(2)(+)) in the distilled water solution and kinetic constraints on its conversion back to cis-PtCl(2)(NH(3))(2) in sea water. Despite its mode of action at the cellular level, cisplatin added up to concentrations of 150 nM did not incur a measurable reduction in the efficiency of photochemical energy conversion under any of experimental conditions tested.
DOI
10.1016/j.envpol.2011.08.018
Publication Date
2011-12-01
Publication Title
Environ Pollut
Volume
159
Issue
12
Organisational Unit
School of Geography, Earth and Environmental Sciences
Keywords
Antineoplastic Agents, Cisplatin, Environmental Monitoring, Seawater, Seaweed, Ulva, Water Pollutants, Chemical
First Page
3504
Last Page
3508
Recommended Citation
Easton, C., Turner, A., & Sewell, G. (2011) 'An evaluation of the toxicity and bioaccumulation of cisplatin in the marine environment using the macroalga, Ulva lactuca.', Environ Pollut, 159(12), pp. 3504-3508. Available at: https://doi.org/10.1016/j.envpol.2011.08.018
