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Abstract

Background The emerging use of biomarkers in research and tailored care introduces a need for information about the association between biomarkers and basic demographics and lifestyle factors revealing expectable concentrations in healthy individuals while considering general demographic differences. Methods A selection of 47 biomarkers, including markers of inflammation and vascular stress, were measured in plasma samples from 9876 Danish Blood Donor Study participants. Using regression models, we examined the association between biomarkers and sex, age, Body Mass Index (BMI), and smoking. Results Here we show that concentrations of inflammation and vascular stress biomarkers generally increase with higher age, BMI, and smoking. Sex-specific effects are observed for multiple biomarkers. Conclusion This study provides comprehensive information on concentrations of 47 plasma biomarkers in healthy individuals. The study emphasizes that knowledge about biomarker concentrations in healthy individuals is critical for improved understanding of disease pathology and for tailored care and decision support tools.

Publication Date

2024-03-16

Publication Title

Communications Medicine

Volume

4

Issue

1

Acceptance Date

2024-03-04

Deposit Date

2025-03-28

Funding

We take this opportunity to express our gratitude to the Danish blood donors for their valuable participation in the Danish Blood Donor Study and to the staff at the blood centers for making this study possible. The Danish Blood Donor Study is funded by the Danish Council for Independent Research—Medical Sciences (8020-00403B), the Danish Administrative Regions and Bio and Genome Bank Denmark, and the Danish Blood Donor Research Foundation. BK and KAK are supported by a grant from BERTHA—the Danish Big Data Centre for Environment and Health, which, in turn, is funded by the Novo Nordisk Foundation Challenge Program (grant NNF17OC0027864). ATL, DW, KB, KSB, TFH, and SB acknowledge the Novo Nordisk Foundation (grants NNF17OC0027594 and NNF14CC0001). MN has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No 101017562. HSN has received funding from the Augustinus Foundation (19-3829). MD received funding from the Danish Council for Independent Research (09-069412). The funders had no role in the design or execution of the study.

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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