ORCID

Abstract

Background The emerging use of biomarkers in research and tailored care introduces a need for information about the association between biomarkers and basic demographics and lifestyle factors revealing expectable concentrations in healthy individuals while considering general demographic differences. Methods A selection of 47 biomarkers, including markers of inflammation and vascular stress, were measured in plasma samples from 9876 Danish Blood Donor Study participants. Using regression models, we examined the association between biomarkers and sex, age, Body Mass Index (BMI), and smoking. Results Here we show that concentrations of inflammation and vascular stress biomarkers generally increase with higher age, BMI, and smoking. Sex-specific effects are observed for multiple biomarkers. Conclusion This study provides comprehensive information on concentrations of 47 plasma biomarkers in healthy individuals. The study emphasizes that knowledge about biomarker concentrations in healthy individuals is critical for improved understanding of disease pathology and for tailored care and decision support tools.

Publication Date

2024-03-16

Publication Title

Communications Medicine

Volume

4

Issue

1

First Page

50

Last Page

50

Plum Print visual indicator of research metrics
PlumX Metrics
  • Citations
    • Citation Indexes: 5
  • Usage
    • Downloads: 8
  • Captures
    • Readers: 14
  • Mentions
    • News Mentions: 1
see details

Share

COinS