Lifestyle and demographic associations with 47 inflammatory and vascular stress biomarkers in 9876 blood donors

Authors

Bertram Kjerulff, Aarhus University
Joseph Dowsett, University of Copenhagen
Rikke Louise Jacobsen, University of Copenhagen
Josephine Gladov, Aarhus University
Margit Hørup Larsen, University of Copenhagen
Agnete Troen Lundgaard, University of Copenhagen
Karina Banasik, University of Copenhagen
David Westergaard, University of Copenhagen
Susan Mikkelsen, Aarhus University
Khoa Manh Dinh, Aarhus University
Lotte Hindhede, Aarhus University
Kathrine Agergård Kaspersen, Aarhus University
Michael Schwinn, University of Copenhagen
Anders Juul, University of Copenhagen
Betina Poulsen, University of Copenhagen
Birgitte Lindegaard, University of Copenhagen
Carsten Bøcker Pedersen, Aarhus University
Clive Eric Sabel, School of Geography, Earth and Environmental Sciences
Henning Bundgaard, University of Copenhagen
Henriette Svarre Nielsen, University of Copenhagen
Janne Amstrup Møller, University of Copenhagen
Jens Kjærgaard Boldsen, Aarhus University
Kristoffer Sølvsten Burgdorf, University of Copenhagen
Lars Vedel Kessing, University of Copenhagen
Linda Jenny Handgaard, University of Copenhagen
Lise Wegner Thørner, University of Copenhagen
Maria Didriksen, University of Copenhagen
Mette Nyegaard, Aarhus University
Niels Grarup, Aarhus University
Niels Ødum, University of Copenhagen

ORCID

• Clive Eric Sabel: 0000-0001-9180-4861

Abstract

Background The emerging use of biomarkers in research and tailored care introduces a need for information about the association between biomarkers and basic demographics and lifestyle factors revealing expectable concentrations in healthy individuals while considering general demographic differences. Methods A selection of 47 biomarkers, including markers of inflammation and vascular stress, were measured in plasma samples from 9876 Danish Blood Donor Study participants. Using regression models, we examined the association between biomarkers and sex, age, Body Mass Index (BMI), and smoking. Results Here we show that concentrations of inflammation and vascular stress biomarkers generally increase with higher age, BMI, and smoking. Sex-specific effects are observed for multiple biomarkers. Conclusion This study provides comprehensive information on concentrations of 47 plasma biomarkers in healthy individuals. The study emphasizes that knowledge about biomarker concentrations in healthy individuals is critical for improved understanding of disease pathology and for tailored care and decision support tools.

DOI

10.1038/s43856-024-00474-2

Publication Date

2024-03-16

Publication Title

Communications Medicine

Volume

4

Issue

1

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

First Page

50

Last Page

50

Recommended Citation

Kjerulff, B., Dowsett, J., Jacobsen, R., Gladov, J., Larsen, M., Lundgaard, A., Banasik, K., Westergaard, D., Mikkelsen, S., Dinh, K., Hindhede, L., Kaspersen, K., Schwinn, M., Juul, A., Poulsen, B., Lindegaard, B., Pedersen, C., Sabel, C., Bundgaard, H., Nielsen, H., Møller, J., Boldsen, J., Burgdorf, K., Kessing, L., Handgaard, L., Thørner, L., Didriksen, M., Nyegaard, M., Grarup, N., & Ødum, N. (2024) 'Lifestyle and demographic associations with 47 inflammatory and vascular stress biomarkers in 9876 blood donors', Communications Medicine, 4(1), pp. 50-50. Available at: https://doi.org/10.1038/s43856-024-00474-2