Afak R S Zaidi

Abstract

Mantle Cell Lymphoma (MCL) is a comparatively rare non-Hodgkin`s lymphoma which is characterised by the overexpression of cyclin D1. Many patients present with or progress to advanced stage disease within three years. Disease progression involves down regulation of cyclin D1. Moreover, MCL is broadly considered as an incurable disease with median survival of patients being 3-4 years. CCN1, a matricellular protein involved in stem cell signalling within the haematopoietic microenvironment is highly expressed in early stage MCL cells and down-regulated in advanced stage disease. We have used the human MCL cell lines REC1

Keywords

Cyclin D1, CCN1, p21, p27, Haematopoietic Microenvironment, Full-length CCN, Truncated form, REC1 KD, JVM2 OE, Proteomics, Macrophage migration inhibitory factor (MIF), Pre-B cell colony enhancing factor (PBEF1), Calmodulin 3 (CALM3), Apolipoprotein M (ApoM), Talin 1 (TLN1), Mantle cell lymphoma (MCL)

Document Type

Thesis

Publication Date

2019

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