ORCID
- Boschetti, Chiara: 0000-0003-4552-3975
Abstract
Oxidative stress results when the production of oxidants outweighs the capacity of the antioxidant defence mechanisms. This can lead to pathological conditions including cancer and neurodegeneration. Consequently, there is considerable interest in compounds with antioxidant activity, including those from natural sources. Here, we characterise the antioxidant activity of three novel peptides identified in protein hydrolysates from the sea cucumber Apostichopus japonicus. Under oxidative stress conditions, synthetic versions of the sea cucumber peptides significantly compensate for glutathione depletion, decrease mitochondrial superoxide levels, and alleviate mitophagy in human neuroblastoma cells. Moreover, orally supplied peptides improve survival of the Caenorhabditis elegans after treatment with paraquat, the latter of which leads to the production of excessive oxidative stress. Thus, the sea cucumber peptides exhibit antioxidant activity at both the cellular and organism levels and might prove attractive as nutritional supplements for healthy ageing.
DOI
10.1155/2021/8842926
Publication Date
2021-03-30
Publication Title
Oxidative Medicine and Cellular Longevity
Volume
2021
First Page
1
Last Page
14
ISSN
1942-0900
Embargo Period
2021-04-22
Organisational Unit
School of Biological and Marine Sciences
Recommended Citation
Lu, M., Mishra, A., Boschetti, C., Lin, J., Liu, Y., Huang, H., Kaminski, C., Huang, Z., Tunnacliffe, A., & Kaminski, C. (2021) 'Sea Cucumber-Derived Peptides Alleviate Oxidative Stress in Neuroblastoma Cells and Improve Survival in C. elegans Exposed to Neurotoxic Paraquat', Oxidative Medicine and Cellular Longevity, 2021, pp. 1-14. Available at: https://doi.org/10.1155/2021/8842926
