Abstract
A critical comparison of studies that have investigated tissue accumulation and toxicity of TiO2-NPs in fish is necessary to resolve inconsistencies. The present study used identical TiO2-NPs, toxicological endpoints, and fish (juvenile rainbow trout Oncorhynchus mykiss) as previous studies that investigated waterborne and dietary toxicity of TiO2-NPs, and conducted a critical comparison of results after intravenous caudal-vein injection of 50 μg of TiO2-NPs and bulk TiO2. Injected TiO2-NPs accumulated only in kidney (94% of measured Ti) and to a lesser extent in spleen; and injected bulk TiO2 was found only in kidney. No toxicity of TiO2 was observed in kidney, spleen, or other tissues. Critical comparison of these data with previous studies indicates that dietary and waterborne exposures to TiO2-NPs do not lead to Ti accumulation in internal tissues, and previous reports of minor toxicity are inconsistent or attributable to respiratory distress resulting from gill occlusion during waterborne exposure.
DOI
10.1016/j.envpol.2013.07.001
Publication Date
2013-07-02
Publication Title
Environ Pollut
Volume
182
First Page
70
Last Page
79
Organisational Unit
School of Biological and Marine Sciences
Keywords
Bioavailability, Nanoparticles, Rainbow trout, Titanium dioxide, Toxicity, Animals, Diet, Gills, Injections, Intravenous, Kidney, Oncorhynchus mykiss, Titanium, Water Pollutants, Chemical
Recommended Citation
Boyle, D., Al-Bairuty, G., Henry, T., & Handy, R. (2013) 'Critical comparison of intravenous injection of TiO2 nanoparticles with waterborne and dietary exposures concludes minimal environmentally-relevant toxicity in juvenile rainbow trout Oncorhynchus mykiss.', Environ Pollut, 182, pp. 70-79. Available at: https://doi.org/10.1016/j.envpol.2013.07.001
