ORCID

Abstract

The genetic landscape of Parkinson’s disease (PD) is characterised by rare high penetrance pathogenic variants causing familial disease, genetic risk factor variants driving PD risk in a significant minority in PD cases and high frequency, low penetrance variants, which contribute a small increase of the risk of developing sporadic PD. This knowledge has the potential to have a major impact in the clinical care of people with PD. We summarise these genetic influences and discuss the implications for therapeutics and clinical trial design.

DOI

10.3390/genes12071006

Publication Date

2021-06-30

Publication Title

Genes

Volume

12

Issue

7

First Page

1006

Last Page

1006

ISSN

2073-4425

Embargo Period

2021-07-06

Organisational Unit

Peninsula Medical School

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

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