ORCID
- Claudia Barros: 0000-0003-0361-0333
- Torsten Bossing: 0000-0002-3277-9130
Abstract
Neural stem cells (NSC) are multipotent, self-renewing cells that give rise to all neural cell types within the central nervous system. During adulthood, most NSCs exist in a quiescent state which can be reactivated in response to metabolic and signalling changes, allowing for long-term continuous neurogenesis and response to injury. Ensuring a critical balance between quiescence and reactivation is required to maintain the limited NSC reservoir and neural replenishment throughout lifetime. The precise mechanisms and signalling pathways behind this balance are at the focus of current research. In this review, we highlight and discuss recent studies using Drosophila, mammalian and zebrafish models contributing to the understanding of molecular mechanisms underlying quiescence and reactivation of NSCs.
Publication Date
2025-05-06
Publication Title
Biomolecules
Volume
15
Issue
5
Recommended Citation
Elkin, A., Robbins, S., Barros, C., & Bossing, T. (2025) 'The Critical Balance Between Quiescence and Reactivation of Neural Stem Cells', Biomolecules, 15(5). Available at: 10.3390/biom15050672
