Sox2 expression in Schwann cells inhibits myelination in vivo and induces influx of macrophages to the nerve
dc.contributor.author | Roberts, SL | |
dc.contributor.author | Zhang, He | |
dc.contributor.author | Doddrell, RDS | |
dc.contributor.author | Mindos, T | |
dc.contributor.author | Drake, LK | |
dc.contributor.author | Onaitis, MW | |
dc.contributor.author | Florio, F | |
dc.contributor.author | Quattrini, A | |
dc.contributor.author | D'Antonio, M | |
dc.contributor.author | Parkinson, David | |
dc.date.accessioned | 2017-09-15T12:07:22Z | |
dc.date.issued | 2017-07-25 | |
dc.identifier.issn | 0950-1991 | |
dc.identifier.issn | 1477-9129 | |
dc.identifier.uri | http://hdl.handle.net/10026.1/9931 | |
dc.description.abstract |
Correct myelination is crucial for the function of the peripheral nervous system. Both positive and negative regulators within the axon and Schwann cell function to ensure the correct onset and progression of myelination during both development and following peripheral nerve injury and repair. The Sox2 transcription factor is well known for its roles in the development and maintenance of progenitor and stem cell populations, but has also been proposed in vitro as a negative regulator of myelination in Schwann cells. We wished to test fully whether Sox2 regulates myelination in vivo and show here that sustained Sox2 expression in vivo blocks myelination in the peripheral nerves and maintains Schwann cells in a proliferative non-differentiated state, associated also with increased inflammation within the nerve. The plasticity of Schwann cells allows them to re-myelinate regenerated axons following injury and we show that re-myelination is also blocked by Sox2 expression in Schwann cells. These findings identify Sox2 as a physiological regulator of Schwann cell myelination in vivo and its potential to play a role in disorders of myelination in the peripheral nervous system. | |
dc.format.extent | 3114-3125 | |
dc.format.medium | Print-Electronic | |
dc.language | en | |
dc.language.iso | en | |
dc.publisher | The Company of Biologists | |
dc.subject | Development | |
dc.subject | Myelination | |
dc.subject | Peripheral Nervous System | |
dc.subject | Repair | |
dc.subject | Schwann cell | |
dc.subject | Sox2 | |
dc.title | Sox2 expression in Schwann cells inhibits myelination in vivo and induces influx of macrophages to the nerve | |
dc.type | journal-article | |
dc.type | Journal Article | |
dc.type | Research Support, Non-U.S. Gov't | |
plymouth.author-url | https://www.ncbi.nlm.nih.gov/pubmed/28743796 | |
plymouth.issue | 17 | |
plymouth.volume | 144 | |
plymouth.publication-status | Published online | |
plymouth.journal | Development | |
dc.identifier.doi | 10.1242/dev.150656 | |
plymouth.organisational-group | /Plymouth | |
plymouth.organisational-group | /Plymouth/Faculty of Health | |
plymouth.organisational-group | /Plymouth/Faculty of Health/Peninsula Medical School | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy | |
plymouth.organisational-group | /Plymouth/Research Groups | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED) | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CBR | |
plymouth.organisational-group | /Plymouth/Users by role | |
plymouth.organisational-group | /Plymouth/Users by role/Academics | |
plymouth.organisational-group | /Plymouth/Users by role/Researchers in ResearchFish submission | |
dc.publisher.place | England | |
dcterms.dateAccepted | 2017-07-13 | |
dc.rights.embargodate | 2018-7-25 | |
dc.identifier.eissn | 1477-9129 | |
dc.rights.embargoperiod | 12 months | |
rioxxterms.funder | Wellcome Trust | |
rioxxterms.identifier.project | The role of Sox-2 in Schwann cell development and plasticity. | |
rioxxterms.versionofrecord | 10.1242/dev.150656 | |
rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/under-embargo-all-rights-reserved | |
rioxxterms.licenseref.startdate | 2017-07-25 | |
rioxxterms.type | Journal Article/Review | |
plymouth.funder | The role of Sox-2 in Schwann cell development and plasticity.::Wellcome Trust |