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dc.contributor.authorRoberts, SL
dc.contributor.authorDun, X-P
dc.contributor.authorDoddrell, RDS
dc.contributor.authorMindos, T
dc.contributor.authorDrake, LK
dc.contributor.authorOnaitis, MW
dc.contributor.authorFlorio, F
dc.contributor.authorQuattrini, A
dc.contributor.authorD'Antonio, M
dc.contributor.authorParkinson, DB
dc.date.accessioned2017-09-15T12:07:22Z
dc.date.issued2017-07-25
dc.identifier.issn0950-1991
dc.identifier.issn1477-9129
dc.identifier.urihttp://hdl.handle.net/10026.1/9931
dc.description.abstract

Correct myelination is crucial for the function of the peripheral nervous system. Both positive and negative regulators within the axon and Schwann cell function to ensure the correct onset and progression of myelination during both development and following peripheral nerve injury and repair. The Sox2 transcription factor is well known for its roles in the development and maintenance of progenitor and stem cell populations, but has also been proposed in vitro as a negative regulator of myelination in Schwann cells. We wished to test fully whether Sox2 regulates myelination in vivo and show here that sustained Sox2 expression in vivo blocks myelination in the peripheral nerves and maintains Schwann cells in a proliferative non-differentiated state, associated also with increased inflammation within the nerve. The plasticity of Schwann cells allows them to re-myelinate regenerated axons following injury and we show that re-myelination is also blocked by Sox2 expression in Schwann cells. These findings identify Sox2 as a physiological regulator of Schwann cell myelination in vivo and its potential to play a role in disorders of myelination in the peripheral nervous system.

dc.format.extent3114-3125
dc.format.mediumPrint-Electronic
dc.languageen
dc.language.isoen
dc.publisherThe Company of Biologists
dc.subjectDevelopment
dc.subjectMyelination
dc.subjectPeripheral Nervous System
dc.subjectRepair
dc.subjectSchwann cell
dc.subjectSox2
dc.titleSox2 expression in Schwann cells inhibits myelination in vivo and induces influx of macrophages to the nerve
dc.typejournal-article
dc.typeArticle
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/28743796
plymouth.issue17
plymouth.volume144
plymouth.publication-statusPublished online
plymouth.journalDevelopment
dc.identifier.doi10.1242/dev.150656
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Faculty of Health/Peninsula Medical School
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CBR
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
plymouth.organisational-group/Plymouth/Users by role/Researchers in ResearchFish submission
dc.publisher.placeEngland
dcterms.dateAccepted2017-07-13
dc.rights.embargodate2018-7-25
dc.identifier.eissn1477-9129
dc.rights.embargoperiod12 months
rioxxterms.funderWellcome Trust
rioxxterms.identifier.projectThe role of Sox-2 in Schwann cell development and plasticity.
rioxxterms.versionofrecord10.1242/dev.150656
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/under-embargo-all-rights-reserved
rioxxterms.licenseref.startdate2017-07-25
rioxxterms.typeJournal Article/Review
plymouth.funderThe role of Sox-2 in Schwann cell development and plasticity.::Wellcome Trust


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