Adjusting for unmeasured confounding in nonrandomized longitudinal studies: a methodological review
dc.contributor.author | Streeter, Adam | |
dc.contributor.author | Lin, NX | |
dc.contributor.author | Crathorne, L | |
dc.contributor.author | Haasova, M | |
dc.contributor.author | Hyde, C | |
dc.contributor.author | Melzer, D | |
dc.contributor.author | Henley, WE | |
dc.date.accessioned | 2017-08-11T11:52:04Z | |
dc.date.available | 2017-08-11T11:52:04Z | |
dc.date.issued | 2017-04-28 | |
dc.identifier.issn | 0895-4356 | |
dc.identifier.issn | 0895-4356 | |
dc.identifier.uri | http://hdl.handle.net/10026.1/9796 | |
dc.description.abstract |
OBJECTIVE: Motivated by recent calls to use electronic health records for research, we reviewed the application and development of methods for addressing the bias from unmeasured confounding in longitudinal data. DESIGN: Methodological review of existing literature SETTING: We searched MEDLINE and EMBASE for articles addressing the threat to causal inference from unmeasured confounding in nonrandomised longitudinal health data through quasi-experimental analysis. RESULTS: Among the 121 studies included for review, 84 used instrumental variable analysis (IVA), of which 36 used lagged or historical instruments. Difference-in-differences (DiD) and fixed effects (FE) models were found in 29 studies. Five of these combined IVA with DiD or FE to try to mitigate for time-dependent confounding. Other less frequently used methods included prior event rate ratio adjustment, regression discontinuity nested within pre-post studies, propensity score calibration, perturbation analysis and negative control outcomes. CONCLUSIONS: Well-established econometric methods such as DiD and IVA are commonly used to address unmeasured confounding in non-randomised, longitudinal studies, but researchers often fail to take full advantage of available longitudinal information. A range of promising new methods have been developed, but further studies are needed to understand their relative performance in different contexts before they can be recommended for widespread use. | |
dc.format.extent | 23-34 | |
dc.format.medium | Print-Electronic | |
dc.language | en | |
dc.language.iso | en | |
dc.publisher | Elsevier BV | |
dc.subject | electronic health records | |
dc.subject | longitudinal | |
dc.subject | method review | |
dc.subject | observational data | |
dc.subject | unmeasured confounding | |
dc.subject | unobserved confounding | |
dc.title | Adjusting for unmeasured confounding in nonrandomized longitudinal studies: a methodological review | |
dc.type | journal-article | |
dc.type | Journal Article | |
dc.type | Review | |
plymouth.author-url | https://www.ncbi.nlm.nih.gov/pubmed/28460857 | |
plymouth.volume | 87 | |
plymouth.publication-status | Published online | |
plymouth.journal | Journal of Clinical Epidemiology | |
dc.identifier.doi | 10.1016/j.jclinepi.2017.04.022 | |
plymouth.organisational-group | /Plymouth | |
plymouth.organisational-group | /Plymouth/Faculty of Health | |
plymouth.organisational-group | /Plymouth/Faculty of Health/Peninsula Medical School | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy | |
plymouth.organisational-group | /Plymouth/Research Groups | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Health and Community | |
plymouth.organisational-group | /Plymouth/Research Groups/Plymouth Institute of Health and Care Research (PIHR) | |
plymouth.organisational-group | /Plymouth/Users by role | |
plymouth.organisational-group | /Plymouth/Users by role/Academics | |
dc.publisher.place | United States | |
dcterms.dateAccepted | 2017-04-24 | |
dc.identifier.eissn | 0895-4356 | |
dc.rights.embargoperiod | No embargo | |
rioxxterms.versionofrecord | 10.1016/j.jclinepi.2017.04.022 | |
rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
rioxxterms.licenseref.startdate | 2017-04-28 | |
rioxxterms.type | Journal Article/Review | |
plymouth.oa-location | https://doi.org/10.1016/j.jclinepi.2017.04.022 |