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dc.contributor.authorDun, X-Pen
dc.contributor.authorParkinson, DBen
dc.date.accessioned2017-08-11T10:15:08Z
dc.date.available2017-08-11T10:15:08Z
dc.date.issued2017-02-24en
dc.identifier.urihttp://hdl.handle.net/10026.1/9773
dc.description.abstract

Netrin-1 was the first axon guidance molecule to be discovered in vertebrates and has a strong chemotropic function for axonal guidance, cell migration, morphogenesis and angiogenesis. It is a secreted axon guidance cue that can trigger attraction by binding to its canonical receptors Deleted in Colorectal Cancer (DCC) and Neogenin or repulsion through binding the DCC/Uncoordinated (Unc5) A-D receptor complex. The crystal structures of Netrin-1/receptor complexes have recently been revealed. These studies have provided a structure based explanation of Netrin-1 bi-functionality. Netrin-1 and its receptor are continuously expressed in the adult nervous system and are differentially regulated after nerve injury. In the adult spinal cord and optic nerve, Netrin-1 has been considered as an inhibitor that contributes to axon regeneration failure after injury. In the peripheral nervous system, Netrin-1 receptors are expressed in Schwann cells, the cell bodies of sensory neurons and the axons of both motor and sensory neurons. Netrin-1 is expressed in Schwann cells and its expression is up-regulated after peripheral nerve transection injury. Recent studies indicated that Netrin-1 plays a positive role in promoting peripheral nerve regeneration, Schwann cell proliferation and migration. Targeting of the Netrin-1 signaling pathway could develop novel therapeutic strategies to promote peripheral nerve regeneration and functional recovery.

en
dc.languageengen
dc.language.isoengen
dc.subjectDCCen
dc.subjectNeogeninen
dc.subjectNetrin-1en
dc.subjectSchwann cellsen
dc.subjectUnc5A–Den
dc.subjectbi-functionalityen
dc.subjectoptic nerveen
dc.subjectperipheral nerveen
dc.subjectregenerationen
dc.subjectspinal corden
dc.subjectAnimalsen
dc.subjectCell Movementen
dc.subjectGene Expressionen
dc.subjectHumansen
dc.subjectNerve Growth Factorsen
dc.subjectNerve Regenerationen
dc.subjectNetrin-1en
dc.subjectOptic Nerveen
dc.subjectPeripheral Nerve Injuriesen
dc.subjectProtein Bindingen
dc.subjectProtein Interaction Domains and Motifsen
dc.subjectProtein Multimerizationen
dc.subjectReceptors, Polymeric Immunoglobulinen
dc.subjectSchwann Cellsen
dc.subjectSignal Transductionen
dc.subjectSpinal Corden
dc.subjectSpinal Cord Injuriesen
dc.subjectTumor Suppressor Proteinsen
dc.titleRole of Netrin-1 Signaling in Nerve Regeneration.en
dc.typeJournal Article
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/28245592en
plymouth.issue3en
plymouth.volume18en
plymouth.publication-statusPublished onlineen
plymouth.journalInt J Mol Scien
dc.identifier.doi10.3390/ijms18030491en
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/00 All current users
plymouth.organisational-group/Plymouth/00 All current users/Academics
plymouth.organisational-group/Plymouth/00 All current users/Academics/Plymouth University Peninsula School of Medicine and Dentistry
plymouth.organisational-group/Plymouth/00 All current users/Academics/Plymouth University Peninsula School of Medicine and Dentistry/PUPSMD - not in Schools
plymouth.organisational-group/Plymouth/Plymouth University Peninsula Schools of Medicine and Dentistry
plymouth.organisational-group/Plymouth/Plymouth University Peninsula Schools of Medicine and Dentistry/Biomedical Research Group
plymouth.organisational-group/Plymouth/Plymouth University Peninsula Schools of Medicine and Dentistry/Biomedical Research Group/RC Reporting Group BRG
plymouth.organisational-group/Plymouth/Plymouth University Peninsula Schools of Medicine and Dentistry/Neuroscience
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CBR
dc.publisher.placeSwitzerlanden
dc.publisher.placeSwitzerlanden
dc.publisher.placeSwitzerlanden
dc.publisher.placeSwitzerlanden
dc.publisher.placeSwitzerlanden
dc.publisher.placeSwitzerlanden
dc.publisher.placeSwitzerlanden
dc.publisher.placeSwitzerlanden
dc.publisher.placeSwitzerlanden
dc.publisher.placeSwitzerlanden
dc.publisher.placeSwitzerlanden
dc.publisher.placeSwitzerlanden
dc.publisher.placeSwitzerlanden
dc.publisher.placeSwitzerlanden
dcterms.dateAccepted2017-02-22en
dc.identifier.eissn1422-0067en
rioxxterms.versionofrecord10.3390/ijms18030491en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2017-02-24en
rioxxterms.typeJournal Article/Reviewen
plymouth.oa-locationhttp://www.mdpi.com/1422-0067/18/3/491en


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