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dc.contributor.authorZhang, He
dc.contributor.authorParkinson, David
dc.date.accessioned2017-08-11T10:15:08Z
dc.date.available2017-08-11T10:15:08Z
dc.date.issued2017-03
dc.identifier.issn1422-0067
dc.identifier.issn1422-0067
dc.identifier.otherARTN 491
dc.identifier.urihttp://hdl.handle.net/10026.1/9773
dc.description.abstract

Netrin-1 was the first axon guidance molecule to be discovered in vertebrates and has a strong chemotropic function for axonal guidance, cell migration, morphogenesis and angiogenesis. It is a secreted axon guidance cue that can trigger attraction by binding to its canonical receptors Deleted in Colorectal Cancer (DCC) and Neogenin or repulsion through binding the DCC/Uncoordinated (Unc5) A-D receptor complex. The crystal structures of Netrin-1/receptor complexes have recently been revealed. These studies have provided a structure based explanation of Netrin-1 bi-functionality. Netrin-1 and its receptor are continuously expressed in the adult nervous system and are differentially regulated after nerve injury. In the adult spinal cord and optic nerve, Netrin-1 has been considered as an inhibitor that contributes to axon regeneration failure after injury. In the peripheral nervous system, Netrin-1 receptors are expressed in Schwann cells, the cell bodies of sensory neurons and the axons of both motor and sensory neurons. Netrin-1 is expressed in Schwann cells and its expression is up-regulated after peripheral nerve transection injury. Recent studies indicated that Netrin-1 plays a positive role in promoting peripheral nerve regeneration, Schwann cell proliferation and migration. Targeting of the Netrin-1 signaling pathway could develop novel therapeutic strategies to promote peripheral nerve regeneration and functional recovery.

dc.format.extent491-491
dc.format.mediumElectronic
dc.languageen
dc.language.isoeng
dc.publisherMDPI AG
dc.subjectNetrin-1
dc.subjectDCC
dc.subjectNeogenin
dc.subjectUnc5A-D
dc.subjectbi-functionality
dc.subjectspinal cord
dc.subjectoptic nerve
dc.subjectperipheral nerve
dc.subjectSchwann cells
dc.subjectregeneration
dc.titleRole of Netrin-1 Signaling in Nerve Regeneration
dc.typejournal-article
dc.typeJournal Article
dc.typeReview
plymouth.author-urlhttps://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000396253700022&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008
plymouth.issue3
plymouth.volume18
plymouth.publication-statusPublished online
plymouth.journalInternational Journal of Molecular Sciences
dc.identifier.doi10.3390/ijms18030491
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Faculty of Health/Peninsula Medical School
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CBR
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
plymouth.organisational-group/Plymouth/Users by role/Researchers in ResearchFish submission
dc.publisher.placeSwitzerland
dcterms.dateAccepted2017-02-22
dc.identifier.eissn1422-0067
dc.rights.embargoperiodNo embargo
rioxxterms.versionofrecord10.3390/ijms18030491
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2017-02-24
rioxxterms.typeJournal Article/Review
plymouth.oa-locationhttp://www.mdpi.com/1422-0067/18/3/491


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