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dc.contributor.authorCrisp, A
dc.contributor.authorBoschetti, Chiara
dc.contributor.authorPerry, M
dc.contributor.authorTunnacliffe, A
dc.contributor.authorMicklem, G
dc.date.accessioned2017-06-02T10:26:34Z
dc.date.available2017-06-02T10:26:34Z
dc.date.issued2015-12
dc.identifier.issn1474-760X
dc.identifier.issn1474-760X
dc.identifier.other50
dc.identifier.urihttp://hdl.handle.net/10026.1/9407
dc.description.abstract

BACKGROUND: A fundamental concept in biology is that heritable material, DNA, is passed from parent to offspring, a process called vertical gene transfer. An alternative mechanism of gene acquisition is through horizontal gene transfer (HGT), which involves movement of genetic material between different species. HGT is well-known in single-celled organisms such as bacteria, but its existence in higher organisms, including animals, is less well established, and is controversial in humans. RESULTS: We have taken advantage of the recent availability of a sufficient number of high-quality genomes and associated transcriptomes to carry out a detailed examination of HGT in 26 animal species (10 primates, 12 flies and four nematodes) and a simplified analysis in a further 14 vertebrates. Genome-wide comparative and phylogenetic analyses show that HGT in animals typically gives rise to tens or hundreds of active 'foreign' genes, largely concerned with metabolism. Our analyses suggest that while fruit flies and nematodes have continued to acquire foreign genes throughout their evolution, humans and other primates have gained relatively few since their common ancestor. We also resolve the controversy surrounding previous evidence of HGT in humans and provide at least 33 new examples of horizontally acquired genes. CONCLUSIONS: We argue that HGT has occurred, and continues to occur, on a previously unsuspected scale in metazoans and is likely to have contributed to biochemical diversification during animal evolution.

dc.format.extent0-0
dc.format.mediumElectronic
dc.languageen
dc.language.isoen
dc.publisherSpringer Science and Business Media LLC
dc.subjectAnimals
dc.subjectBacteria
dc.subjectEvolution, Molecular
dc.subjectGene Expression
dc.subjectGene Transfer, Horizontal
dc.subjectGenome
dc.subjectHumans
dc.subjectInvertebrates
dc.subjectNematoda
dc.subjectPhylogeny
dc.subjectVertebrates
dc.titleExpression of multiple horizontally acquired genes is a hallmark of both vertebrate and invertebrate genomes
dc.typejournal-article
dc.typeJournal Article
dc.typeResearch Support, Non-U.S. Gov't
plymouth.author-urlhttps://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000351824700001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008
plymouth.issue1
plymouth.volume16
plymouth.publication-statusPublished
plymouth.journalGenome Biology
dc.identifier.doi10.1186/s13059-015-0607-3
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Science and Engineering
plymouth.organisational-group/Plymouth/Faculty of Science and Engineering/School of Biological and Marine Sciences
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA06 Agriculture, Veterinary and Food Science
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
dc.publisher.placeEngland
dcterms.dateAccepted2015-02-04
dc.identifier.eissn1474-760X
dc.rights.embargoperiodNo embargo
rioxxterms.versionofrecord10.1186/s13059-015-0607-3
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2015-12
rioxxterms.typeJournal Article/Review


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