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dc.contributor.authorJeffery, Alison
dc.contributor.authorMetcalf, BS
dc.contributor.authorHosking, Joanne
dc.contributor.authorStreeter, Adam
dc.contributor.authorVoss, LD
dc.contributor.authorWilkin, TJ
dc.date.accessioned2017-05-25T11:59:37Z
dc.date.available2017-05-25T11:59:37Z
dc.date.issued2012-03-01
dc.identifier.issn0149-5992
dc.identifier.issn1935-5548
dc.identifier.urihttp://hdl.handle.net/10026.1/9349
dc.description.abstract

<jats:sec> <jats:title>OBJECTIVE</jats:title> <jats:p>Insulin resistance (IR) is associated with diabetes. IR is higher during puberty in both sexes, with some studies showing the increase to be independent of changes in adiposity. Few longitudinal studies have reported on children, and it remains unclear when the rise in IR that is often attributed to puberty really begins. We sought to establish from longitudinal data its relationship to pubertal onset, and interactions with age, sex, adiposity, and IGF-1.</jats:p> </jats:sec> <jats:sec> <jats:title>RESEARCH DESIGN AND METHODS</jats:title> <jats:p>The EarlyBird Diabetes study is a longitudinal prospective cohort study of healthy children aged 5–14 years. Homeostasis model assessment (HOMA-IR), skinfolds (SSF), adiposity (percent fat, measured by dual-energy X-ray absorptiometry), serum leptin, and IGF-1 were measured annually in 235 children (134 boys). Pubertal onset was adduced from Tanner stage (TS) and from the age at which luteinizing hormone (LH) first became serially detectable (≥0.2 international units/L).</jats:p> </jats:sec> <jats:sec> <jats:title>RESULTS</jats:title> <jats:p>IR rose progressively from age 7 years, 3–4 years before TS2 was reached or LH became detectable. Rising adiposity and IGF-1 together explained 34% of the variance in IR in boys and 35% in girls (both P &amp;lt; 0.001) over the 3 years preceding pubertal onset. The contribution of IGF-1 to IR was greater in boys, despite their comparatively lower IGF-1 levels.</jats:p> </jats:sec> <jats:sec> <jats:title>CONCLUSIONS</jats:title> <jats:p>IR starts to rise in mid-childhood, some years before puberty. Its emergence relates more to the age of the child than to pubertal onset. More than 60% of the variation in IR prior to puberty was unexplained. The demography of childhood diabetes is changing, and prepubertal IR may be important.</jats:p> </jats:sec>

dc.format.extent536-541
dc.format.mediumPrint-Electronic
dc.languageen
dc.language.isoeng
dc.publisherAmerican Diabetes Association
dc.subjectAbsorptiometry, Photon
dc.subjectAdiposity
dc.subjectAdolescent
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectFemale
dc.subjectHumans
dc.subjectInsulin Resistance
dc.subjectInsulin-Like Growth Factor I
dc.subjectLeptin
dc.subjectLongitudinal Studies
dc.subjectLuteinizing Hormone
dc.subjectMale
dc.subjectProspective Studies
dc.subjectPuberty
dc.titleAge Before Stage: Insulin Resistance Rises Before the Onset of Puberty
dc.typejournal-article
dc.typeJournal Article
dc.typeResearch Support, Non-U.S. Gov't
plymouth.author-urlhttps://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000300801400018&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008
plymouth.issue3
plymouth.volume35
plymouth.publication-statusPublished
plymouth.journalDiabetes Care
dc.identifier.doi10.2337/dc11-1281
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Faculty of Health/Peninsula Medical School
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/Institute of Health and Community
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CBBB
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CCT&PS
plymouth.organisational-group/Plymouth/Research Groups/Plymouth Institute of Health and Care Research (PIHR)
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
dc.publisher.placeUnited States
dc.identifier.eissn1935-5548
dc.rights.embargoperiodNo embargo
rioxxterms.versionofrecord10.2337/dc11-1281
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.typeJournal Article/Review


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