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dc.contributor.authorLewis, LA
dc.contributor.authorPolanski, K
dc.contributor.authorde Torres-Zabala, M
dc.contributor.authorJayaraman, S
dc.contributor.authorBowden, L
dc.contributor.authorMoore, J
dc.contributor.authorPenfold, CA
dc.contributor.authorJenkins, DJ
dc.contributor.authorHill, C
dc.contributor.authorBaxter, L
dc.contributor.authorKulasekaran, S
dc.contributor.authorTruman, W
dc.contributor.authorLittlejohn, G
dc.contributor.authorPrusinska, J
dc.contributor.authorMead, A
dc.contributor.authorSteinbrenner, J
dc.contributor.authorHickman, R
dc.contributor.authorRand, D
dc.contributor.authorWild, DL
dc.contributor.authorOtt, S
dc.contributor.authorBuchanan-Wollaston, V
dc.contributor.authorSmirnoff, N
dc.contributor.authorBeynon, J
dc.contributor.authorDenby, K
dc.contributor.authorGrant, M
dc.date.accessioned2017-05-24T19:09:52Z
dc.date.available2017-05-24T19:09:52Z
dc.date.issued2015-11
dc.identifier.issn1040-4651
dc.identifier.issn1532-298X
dc.identifier.urihttp://hdl.handle.net/10026.1/9338
dc.description.abstract

Transcriptional reprogramming is integral to effective plant defense. Pathogen effectors act transcriptionally and posttranscriptionally to suppress defense responses. A major challenge to understanding disease and defense responses is discriminating between transcriptional reprogramming associated with microbial-associated molecular pattern (MAMP)-triggered immunity (MTI) and that orchestrated by effectors. A high-resolution time course of genome-wide expression changes following challenge with Pseudomonas syringae pv tomato DC3000 and the nonpathogenic mutant strain DC3000hrpA- allowed us to establish causal links between the activities of pathogen effectors and suppression of MTI and infer with high confidence a range of processes specifically targeted by effectors. Analysis of this information-rich data set with a range of computational tools provided insights into the earliest transcriptional events triggered by effector delivery, regulatory mechanisms recruited, and biological processes targeted. We show that the majority of genes contributing to disease or defense are induced within 6 h postinfection, significantly before pathogen multiplication. Suppression of chloroplast-associated genes is a rapid MAMP-triggered defense response, and suppression of genes involved in chromatin assembly and induction of ubiquitin-related genes coincide with pathogen-induced abscisic acid accumulation. Specific combinations of promoter motifs are engaged in fine-tuning the MTI response and active transcriptional suppression at specific promoter configurations by P. syringae.

dc.format.extent3038-3064
dc.format.mediumPrint-Electronic
dc.languageen
dc.language.isoeng
dc.publisherOxford University Press (OUP)
dc.subjectArabidopsis
dc.subjectBase Sequence
dc.subjectChromatin
dc.subjectGene Expression Profiling
dc.subjectGene Expression Regulation, Plant
dc.subjectGene Ontology
dc.subjectGene Regulatory Networks
dc.subjectGenes, Plant
dc.subjectImmunosuppression Therapy
dc.subjectMolecular Sequence Data
dc.subjectNucleotide Motifs
dc.subjectPathogen-Associated Molecular Pattern Molecules
dc.subjectPlant Diseases
dc.subjectPlant Immunity
dc.subjectPlant Leaves
dc.subjectPromoter Regions, Genetic
dc.subjectPseudomonas syringae
dc.subjectTranscription Factors
dc.subjectTranscription, Genetic
dc.titleTranscriptional Dynamics Driving MAMP-Triggered Immunity and Pathogen Effector-Mediated Immunosuppression in Arabidopsis Leaves Following Infection with <i>Pseudomonas syringae</i> pv tomato DC3000
dc.typejournal-article
dc.typeArticle
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/26566919
plymouth.issue11
plymouth.volume27
plymouth.publisher-urlhttp://dx.doi.org/10.1105/tpc.15.00471
plymouth.publication-statusPublished
plymouth.journalThe Plant Cell
dc.identifier.doi10.1105/tpc.15.00471
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Science and Engineering
plymouth.organisational-group/Plymouth/Faculty of Science and Engineering/School of Biological and Marine Sciences
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA06 Agriculture, Veterinary and Food Science
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
dc.publisher.placeEngland
dcterms.dateAccepted2015-10-22
dc.identifier.eissn1532-298X
dc.rights.embargoperiodNo embargo
rioxxterms.versionofrecord10.1105/tpc.15.00471
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2015-11
rioxxterms.typeJournal Article/Review


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