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dc.contributor.authorLewis, LAen
dc.contributor.authorPolanski, Ken
dc.contributor.authorde Torres-Zabala, Men
dc.contributor.authorJayaraman, Sen
dc.contributor.authorBowden, Len
dc.contributor.authorMoore, Jen
dc.contributor.authorPenfold, CAen
dc.contributor.authorJenkins, DJen
dc.contributor.authorHill, Cen
dc.contributor.authorBaxter, Len
dc.contributor.authorKulasekaran, Sen
dc.contributor.authorTruman, Wen
dc.contributor.authorLittlejohn, Gen
dc.contributor.authorPrusinska, Jen
dc.contributor.authorMead, Aen
dc.contributor.authorSteinbrenner, Jen
dc.contributor.authorHickman, Ren
dc.contributor.authorRand, Den
dc.contributor.authorWild, DLen
dc.contributor.authorOtt, Sen
dc.contributor.authorBuchanan-Wollaston, Ven
dc.contributor.authorSmirnoff, Nen
dc.contributor.authorBeynon, Jen
dc.contributor.authorDenby, Ken
dc.contributor.authorGrant, Men
dc.date.accessioned2017-05-24T19:09:52Z
dc.date.available2017-05-24T19:09:52Z
dc.date.issued2015-11en
dc.identifier.urihttp://hdl.handle.net/10026.1/9338
dc.description.abstract

Transcriptional reprogramming is integral to effective plant defense. Pathogen effectors act transcriptionally and posttranscriptionally to suppress defense responses. A major challenge to understanding disease and defense responses is discriminating between transcriptional reprogramming associated with microbial-associated molecular pattern (MAMP)-triggered immunity (MTI) and that orchestrated by effectors. A high-resolution time course of genome-wide expression changes following challenge with Pseudomonas syringae pv tomato DC3000 and the nonpathogenic mutant strain DC3000hrpA- allowed us to establish causal links between the activities of pathogen effectors and suppression of MTI and infer with high confidence a range of processes specifically targeted by effectors. Analysis of this information-rich data set with a range of computational tools provided insights into the earliest transcriptional events triggered by effector delivery, regulatory mechanisms recruited, and biological processes targeted. We show that the majority of genes contributing to disease or defense are induced within 6 h postinfection, significantly before pathogen multiplication. Suppression of chloroplast-associated genes is a rapid MAMP-triggered defense response, and suppression of genes involved in chromatin assembly and induction of ubiquitin-related genes coincide with pathogen-induced abscisic acid accumulation. Specific combinations of promoter motifs are engaged in fine-tuning the MTI response and active transcriptional suppression at specific promoter configurations by P. syringae.

en
dc.format.extent3038 - 3064en
dc.languageengen
dc.language.isoengen
dc.subjectArabidopsisen
dc.subjectBase Sequenceen
dc.subjectChromatinen
dc.subjectGene Expression Profilingen
dc.subjectGene Expression Regulation, Planten
dc.subjectGene Ontologyen
dc.subjectGene Regulatory Networksen
dc.subjectGenes, Planten
dc.subjectImmunosuppressionen
dc.subjectMolecular Sequence Dataen
dc.subjectNucleotide Motifsen
dc.subjectPathogen-Associated Molecular Pattern Moleculesen
dc.subjectPlant Diseasesen
dc.subjectPlant Immunityen
dc.subjectPlant Leavesen
dc.subjectPromoter Regions, Geneticen
dc.subjectPseudomonas syringaeen
dc.subjectTranscription Factorsen
dc.subjectTranscription, Geneticen
dc.titleTranscriptional Dynamics Driving MAMP-Triggered Immunity and Pathogen Effector-Mediated Immunosuppression in Arabidopsis Leaves Following Infection with Pseudomonas syringae pv tomato DC3000.en
dc.typeJournal Article
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/26566919en
plymouth.issue11en
plymouth.volume27en
plymouth.publication-statusPublisheden
plymouth.journalPlant Cellen
dc.identifier.doi10.1105/tpc.15.00471en
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/00 Groups by role
plymouth.organisational-group/Plymouth/00 Groups by role/Academics
plymouth.organisational-group/Plymouth/Faculty of Science and Engineering
plymouth.organisational-group/Plymouth/Faculty of Science and Engineering/School of Biological and Marine Sciences
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA06 Agriculture, Veterinary and Food Science
dc.publisher.placeUnited Statesen
dcterms.dateAccepted2015-10-22en
dc.identifier.eissn1532-298Xen
dc.rights.embargoperiodNo embargoen
rioxxterms.versionofrecord10.1105/tpc.15.00471en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2015-11en
rioxxterms.typeJournal Article/Reviewen


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