Acclimation of Oxygenic Photosynthesis to Iron Starvation Is Controlled by the sRNA IsaR1
dc.contributor.author | Georg, J | |
dc.contributor.author | Kostova, G | |
dc.contributor.author | Vuorijoki, L | |
dc.contributor.author | Schön, V | |
dc.contributor.author | Kadowaki, T | |
dc.contributor.author | Huokko, T | |
dc.contributor.author | Baumgartner, D | |
dc.contributor.author | Müller, M | |
dc.contributor.author | Klähn, S | |
dc.contributor.author | Allahverdiyeva, Y | |
dc.contributor.author | Hihara, Y | |
dc.contributor.author | Futschik, Matthias | |
dc.contributor.author | Aro, E-M | |
dc.contributor.author | Hess, WR | |
dc.date.accessioned | 2017-05-21T10:16:15Z | |
dc.date.available | 2017-05-21T10:16:15Z | |
dc.date.issued | 2017-05-04 | |
dc.identifier.issn | 0960-9822 | |
dc.identifier.issn | 1879-0445 | |
dc.identifier.uri | http://hdl.handle.net/10026.1/9292 | |
dc.description.abstract |
Oxygenic photosynthesis crucially depends on proteins that possess Fe2+ or Fe/S complexes as co-factors or prosthetic groups. Here, we show that the small regulatory RNA (sRNA) IsaR1 (Iron-Stress-Activated RNA 1) plays a pivotal role in acclimation to low-iron conditions. The IsaR1 regulon consists of more than 15 direct targets, including Fe2+-containing proteins involved in photosynthetic electron transfer, detoxification of anion radicals, citrate cycle, and tetrapyrrole biogenesis. IsaR1 is essential for maintaining physiological levels of Fe/S cluster biogenesis proteins during iron deprivation. Consequently, IsaR1 affects the acclimation of the photosynthetic apparatus to iron starvation at three levels: (1) directly, via posttranscriptional repression of gene expression; (2) indirectly, via suppression of pigment; and (3) Fe/S cluster biosynthesis. Homologs of IsaR1 are widely conserved throughout the cyanobacterial phylum. We conclude that IsaR1 is a critically important riboregulator. These findings provide a new perspective for understanding the regulation of iron homeostasis in photosynthetic organisms. | |
dc.format.extent | 1425-1436.e7 | |
dc.format.medium | Print-Electronic | |
dc.language | en | |
dc.language.iso | en | |
dc.publisher | Elsevier BV | |
dc.subject | Fe/S cluster biogenesis | |
dc.subject | Synechocystis | |
dc.subject | cytochrome b(6)f complex | |
dc.subject | electron transfer | |
dc.subject | ferredoxin I | |
dc.subject | iron homeostasis | |
dc.subject | photosynthesis | |
dc.subject | regulatory sRNA | |
dc.subject | Acclimatization | |
dc.subject | Bacterial Proteins | |
dc.subject | Cyanobacteria | |
dc.subject | Gene Expression Profiling | |
dc.subject | Homeostasis | |
dc.subject | Iron Deficiencies | |
dc.subject | Iron-Sulfur Proteins | |
dc.subject | Oxygen | |
dc.subject | Photosynthesis | |
dc.subject | RNA, Bacterial | |
dc.subject | RNA, Small Untranslated | |
dc.subject | Transcription, Genetic | |
dc.subject | Transcriptome | |
dc.title | Acclimation of Oxygenic Photosynthesis to Iron Starvation Is Controlled by the sRNA IsaR1 | |
dc.type | journal-article | |
dc.type | Journal Article | |
plymouth.author-url | https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000401696100017&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008 | |
plymouth.issue | 10 | |
plymouth.volume | 27 | |
plymouth.publication-status | Published | |
plymouth.journal | Current Biology | |
dc.identifier.doi | 10.1016/j.cub.2017.04.010 | |
plymouth.organisational-group | /Plymouth | |
plymouth.organisational-group | /Plymouth/Faculty of Health | |
plymouth.organisational-group | /Plymouth/Users by role | |
dc.publisher.place | England | |
dcterms.dateAccepted | 2017-04-10 | |
dc.rights.embargodate | 2018-5-4 | |
dc.identifier.eissn | 1879-0445 | |
dc.rights.embargoperiod | Not known | |
rioxxterms.versionofrecord | 10.1016/j.cub.2017.04.010 | |
rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
rioxxterms.licenseref.startdate | 2017-05-04 | |
rioxxterms.type | Journal Article/Review |