Hepatitis C Virus, Cholesterol and Lipoproteins — Impact for the Viral Life Cycle and Pathogenesis of Liver Disease
dc.contributor.author | Felmlee, Daniel | |
dc.contributor.author | Hafirassou, M | |
dc.contributor.author | Lefevre, M | |
dc.contributor.author | Baumert, T | |
dc.contributor.author | Schuster, C | |
dc.date.accessioned | 2017-05-17T15:00:14Z | |
dc.date.available | 2017-05-17T15:00:14Z | |
dc.date.issued | 2013-05 | |
dc.identifier.issn | 1999-4915 | |
dc.identifier.issn | 1999-4915 | |
dc.identifier.uri | http://hdl.handle.net/10026.1/9273 | |
dc.description.abstract |
Hepatitis C virus (HCV) is a leading cause of chronic liver disease, including chronic hepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma. Hepatitis C infection associates with lipid and lipoprotein metabolism disorders such as hepatic steatosis, hypobetalipoproteinemia, and hypocholesterolemia. Furthermore, virus production is dependent on hepatic very-low-density lipoprotein (VLDL) assembly, and circulating virions are physically associated with lipoproteins in complexes termed lipoviral particles. Evidence has indicated several functional roles for the formation of these complexes, including co-opting of lipoprotein receptors for attachment and entry, concealing epitopes to facilitate immune escape, and hijacking host factors for HCV maturation and secretion. Here, we review the evidence surrounding pathogenesis of the hepatitis C infection regarding lipoprotein engagement, cholesterol and triglyceride regulation, and the molecular mechanisms underlying these effects. | |
dc.format.extent | 1292-1324 | |
dc.format.medium | Electronic | |
dc.language | en | |
dc.language.iso | eng | |
dc.publisher | MDPI AG | |
dc.subject | Hepatitis C virus | |
dc.subject | lipoproteins | |
dc.subject | apolipoproteins | |
dc.subject | apoE | |
dc.subject | apoB | |
dc.subject | cholesterol | |
dc.subject | triglyceride | |
dc.subject | viral attachment | |
dc.subject | entry | |
dc.subject | assembly | |
dc.subject | secretion | |
dc.subject | viral immune escape | |
dc.subject | lipid disorder | |
dc.title | Hepatitis C Virus, Cholesterol and Lipoproteins — Impact for the Viral Life Cycle and Pathogenesis of Liver Disease | |
dc.type | journal-article | |
dc.type | Journal Article | |
dc.type | Research Support, Non-U.S. Gov't | |
dc.type | Review | |
plymouth.author-url | https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000319438000007&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008 | |
plymouth.issue | 5 | |
plymouth.volume | 5 | |
plymouth.publication-status | Published online | |
plymouth.journal | Viruses | |
dc.identifier.doi | 10.3390/v5051292 | |
plymouth.organisational-group | /Plymouth | |
plymouth.organisational-group | /Plymouth/Faculty of Health | |
plymouth.organisational-group | /Plymouth/Faculty of Health/Peninsula Medical School | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine | |
plymouth.organisational-group | /Plymouth/Users by role | |
plymouth.organisational-group | /Plymouth/Users by role/Academics | |
dc.publisher.place | Switzerland | |
dcterms.dateAccepted | 2013-04-27 | |
dc.identifier.eissn | 1999-4915 | |
dc.rights.embargoperiod | No embargo | |
rioxxterms.versionofrecord | 10.3390/v5051292 | |
rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
rioxxterms.licenseref.startdate | 2013-05-23 | |
rioxxterms.type | Journal Article/Review |