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dc.contributor.authorFelmlee, Daniel
dc.contributor.authorHafirassou, M
dc.contributor.authorLefevre, M
dc.contributor.authorBaumert, T
dc.contributor.authorSchuster, C
dc.date.accessioned2017-05-17T15:00:14Z
dc.date.available2017-05-17T15:00:14Z
dc.date.issued2013-05
dc.identifier.issn1999-4915
dc.identifier.issn1999-4915
dc.identifier.urihttp://hdl.handle.net/10026.1/9273
dc.description.abstract

Hepatitis C virus (HCV) is a leading cause of chronic liver disease, including chronic hepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma. Hepatitis C infection associates with lipid and lipoprotein metabolism disorders such as hepatic steatosis, hypobetalipoproteinemia, and hypocholesterolemia. Furthermore, virus production is dependent on hepatic very-low-density lipoprotein (VLDL) assembly, and circulating virions are physically associated with lipoproteins in complexes termed lipoviral particles. Evidence has indicated several functional roles for the formation of these complexes, including co-opting of lipoprotein receptors for attachment and entry, concealing epitopes to facilitate immune escape, and hijacking host factors for HCV maturation and secretion. Here, we review the evidence surrounding pathogenesis of the hepatitis C infection regarding lipoprotein engagement, cholesterol and triglyceride regulation, and the molecular mechanisms underlying these effects.

dc.format.extent1292-1324
dc.format.mediumElectronic
dc.languageen
dc.language.isoeng
dc.publisherMDPI AG
dc.subjectHepatitis C virus
dc.subjectlipoproteins
dc.subjectapolipoproteins
dc.subjectapoE
dc.subjectapoB
dc.subjectcholesterol
dc.subjecttriglyceride
dc.subjectviral attachment
dc.subjectentry
dc.subjectassembly
dc.subjectsecretion
dc.subjectviral immune escape
dc.subjectlipid disorder
dc.titleHepatitis C Virus, Cholesterol and Lipoproteins — Impact for the Viral Life Cycle and Pathogenesis of Liver Disease
dc.typejournal-article
dc.typeJournal Article
dc.typeResearch Support, Non-U.S. Gov't
dc.typeReview
plymouth.author-urlhttps://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000319438000007&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008
plymouth.issue5
plymouth.volume5
plymouth.publication-statusPublished online
plymouth.journalViruses
dc.identifier.doi10.3390/v5051292
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Faculty of Health/Peninsula Medical School
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
dc.publisher.placeSwitzerland
dcterms.dateAccepted2013-04-27
dc.identifier.eissn1999-4915
dc.rights.embargoperiodNo embargo
rioxxterms.versionofrecord10.3390/v5051292
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2013-05-23
rioxxterms.typeJournal Article/Review


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