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dc.contributor.authorFelmlee, DJen
dc.contributor.authorHafirassou, MLen
dc.contributor.authorLefevre, Men
dc.contributor.authorBaumert, TFen
dc.contributor.authorSchuster, Cen
dc.date.accessioned2017-05-17T15:00:14Z
dc.date.available2017-05-17T15:00:14Z
dc.date.issued2013-05-23en
dc.identifier.urihttp://hdl.handle.net/10026.1/9273
dc.description.abstract

Hepatitis C virus (HCV) is a leading cause of chronic liver disease, including chronic hepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma. Hepatitis C infection associates with lipid and lipoprotein metabolism disorders such as hepatic steatosis, hypobetalipoproteinemia, and hypocholesterolemia. Furthermore, virus production is dependent on hepatic very-low-density lipoprotein (VLDL) assembly, and circulating virions are physically associated with lipoproteins in complexes termed lipoviral particles. Evidence has indicated several functional roles for the formation of these complexes, including co-opting of lipoprotein receptors for attachment and entry, concealing epitopes to facilitate immune escape, and hijacking host factors for HCV maturation and secretion. Here, we review the evidence surrounding pathogenesis of the hepatitis C infection regarding lipoprotein engagement, cholesterol and triglyceride regulation, and the molecular mechanisms underlying these effects.

en
dc.format.extent1292 - 1324en
dc.languageengen
dc.language.isoengen
dc.subjectCholesterolen
dc.subjectHepacivirusen
dc.subjectHepatitis Cen
dc.subjectHumansen
dc.subjectLipoproteinsen
dc.subjectTriglyceridesen
dc.subjectVirus Assemblyen
dc.subjectVirus Internalizationen
dc.subjectVirus Releaseen
dc.titleHepatitis C virus, cholesterol and lipoproteins--impact for the viral life cycle and pathogenesis of liver disease.en
dc.typeJournal Article
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/23698400en
plymouth.issue5en
plymouth.volume5en
plymouth.publication-statusPublished onlineen
plymouth.journalVirusesen
dc.identifier.doi10.3390/v5051292en
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/00 Groups by role
plymouth.organisational-group/Plymouth/00 Groups by role/Academics
plymouth.organisational-group/Plymouth/Faculty of Medicine and Dentistry
plymouth.organisational-group/Plymouth/Faculty of Medicine and Dentistry/Biomedical Research Group
plymouth.organisational-group/Plymouth/Faculty of Medicine and Dentistry/Biomedical Research Group/RC Reporting Group BRG
plymouth.organisational-group/Plymouth/Faculty of Medicine and Dentistry/Collaboration for the Advancement of Medical Education Research Assessment
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine
dc.publisher.placeSwitzerlanden
dcterms.dateAccepted2013-04-27en
dc.identifier.eissn1999-4915en
dc.rights.embargoperiodNo embargoen
rioxxterms.versionofrecord10.3390/v5051292en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2013-05-23en
rioxxterms.typeJournal Article/Reviewen


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