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dc.contributor.authorFafi-Kremer, S
dc.contributor.authorFauvelle, C
dc.contributor.authorFelmlee, DJ
dc.contributor.authorZeisel, MB
dc.contributor.authorLepiller, Q
dc.contributor.authorFofana, I
dc.contributor.authorHeydmann, L
dc.contributor.authorStoll-Keller, F
dc.contributor.authorBaumert, TF
dc.date.accessioned2017-05-17T14:59:41Z
dc.date.available2017-05-17T14:59:41Z
dc.date.issued2012
dc.identifier.issn1999-4915
dc.identifier.issn1999-4915
dc.identifier.urihttp://hdl.handle.net/10026.1/9272
dc.description.abstract

Hepatitis C virus (HCV) infection is a major cause of chronic liver disease worldwide. The interplay between the virus and host innate and adaptive immune responses determines the outcome of infection. There is increasing evidence that host neutralizing responses play a relevant role in the resulting pathogenesis. Furthermore, viral evasion from host neutralizing antibodies has been revealed to be an important contributor in leading both to viral persistence in acute liver graft infection following liver transplantation, and to chronic viral infection. The development of novel model systems to study HCV entry and neutralization has allowed a detailed understanding of the molecular mechanisms of virus-host interactions during antibody-mediated neutralization. The understanding of these mechanisms will ultimately contribute to the development of novel antiviral preventive strategies for liver graft infection and an urgently needed vaccine. This review summarizes recent concepts of the role of neutralizing antibodies in viral clearance and protection, and highlights consequences of viral escape from neutralizing antibodies in the pathogenesis of HCV infection.

dc.format.extent2016-2030
dc.format.mediumElectronic
dc.languageen
dc.language.isoeng
dc.publisherMDPI AG
dc.subjectantiviral
dc.subjectevasion
dc.subjectliver
dc.subjecttransplantation
dc.subjectvaccine
dc.titleNeutralizing Antibodies and Pathogenesis of Hepatitis C Virus Infection
dc.typejournal-article
dc.typeReview
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/23202451
plymouth.issue10
plymouth.volume4
plymouth.publication-statusPublished online
plymouth.journalViruses
dc.identifier.doi10.3390/v4102016
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Faculty of Health/Peninsula Medical School
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
dc.publisher.placeSwitzerland
dcterms.dateAccepted2012-09-28
dc.identifier.eissn1999-4915
dc.rights.embargoperiodNo embargo
rioxxterms.versionofrecord10.3390/v4102016
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2012-10-09
rioxxterms.typeJournal Article/Review


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