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dc.contributor.authorFafi-Kremer, Sen
dc.contributor.authorFauvelle, Cen
dc.contributor.authorFelmlee, DJen
dc.contributor.authorZeisel, MBen
dc.contributor.authorLepiller, Qen
dc.contributor.authorFofana, Ien
dc.contributor.authorHeydmann, Len
dc.contributor.authorStoll-Keller, Fen
dc.contributor.authorBaumert, TFen
dc.date.accessioned2017-05-17T14:59:41Z
dc.date.available2017-05-17T14:59:41Z
dc.date.issued2012-10-09en
dc.identifier.urihttp://hdl.handle.net/10026.1/9272
dc.description.abstract

Hepatitis C virus (HCV) infection is a major cause of chronic liver disease worldwide. The interplay between the virus and host innate and adaptive immune responses determines the outcome of infection. There is increasing evidence that host neutralizing responses play a relevant role in the resulting pathogenesis. Furthermore, viral evasion from host neutralizing antibodies has been revealed to be an important contributor in leading both to viral persistence in acute liver graft infection following liver transplantation, and to chronic viral infection. The development of novel model systems to study HCV entry and neutralization has allowed a detailed understanding of the molecular mechanisms of virus-host interactions during antibody-mediated neutralization. The understanding of these mechanisms will ultimately contribute to the development of novel antiviral preventive strategies for liver graft infection and an urgently needed vaccine. This review summarizes recent concepts of the role of neutralizing antibodies in viral clearance and protection, and highlights consequences of viral escape from neutralizing antibodies in the pathogenesis of HCV infection.

en
dc.format.extent2016 - 2030en
dc.languageengen
dc.language.isoengen
dc.subjectAnimalsen
dc.subjectAntibodies, Neutralizingen
dc.subjectB-Lymphocytesen
dc.subjectCD8-Positive T-Lymphocytesen
dc.subjectHepacivirusen
dc.subjectHepatitis C Antibodiesen
dc.subjectHepatitis C, Chronicen
dc.subjectHumansen
dc.subjectImmune Evasionen
dc.subjectImmunity, Humoralen
dc.subjectLiveren
dc.subjectLiver Transplantationen
dc.subjectViral Envelope Proteinsen
dc.subjectVirus Internalizationen
dc.titleNeutralizing antibodies and pathogenesis of hepatitis C virus infection.en
dc.typeJournal Article
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/23202451en
plymouth.issue10en
plymouth.volume4en
plymouth.publication-statusPublished onlineen
plymouth.journalVirusesen
dc.identifier.doi10.3390/v4102016en
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Faculty of Health/Peninsula Medical School
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
dc.publisher.placeSwitzerlanden
dcterms.dateAccepted2012-09-28en
dc.identifier.eissn1999-4915en
dc.rights.embargoperiodNo embargoen
rioxxterms.versionofrecord10.3390/v4102016en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2012-10-09en
rioxxterms.typeJournal Article/Reviewen


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