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dc.contributor.authorSinger, ACen
dc.contributor.authorHoward, BMen
dc.contributor.authorJohnson, ACen
dc.contributor.authorKnowles, CJen
dc.contributor.authorJackman, Sen
dc.contributor.authorAccinelli, Cen
dc.contributor.authorCaracciolo, ABen
dc.contributor.authorBernard, Ien
dc.contributor.authorBird, Sen
dc.contributor.authorBoucard, Ten
dc.contributor.authorBoxall, Aen
dc.contributor.authorBrian, JVen
dc.contributor.authorCartmell, Een
dc.contributor.authorChubb, Cen
dc.contributor.authorChurchley, Jen
dc.contributor.authorCostigan, Sen
dc.contributor.authorCrane, Men
dc.contributor.authorDempsey, MJen
dc.contributor.authorDorrington, Ben
dc.contributor.authorEllor, Ben
dc.contributor.authorFick, Jen
dc.contributor.authorHolmes, Jen
dc.contributor.authorHutchinson, Ten
dc.contributor.authorKarcher, Fen
dc.contributor.authorKelleher, SLen
dc.contributor.authorMarsden, Pen
dc.contributor.authorNoone, Gen
dc.contributor.authorNunn, MAen
dc.contributor.authorOxford, Jen
dc.contributor.authorRachwal, Ten
dc.contributor.authorRoberts, Nen
dc.contributor.authorRoberts, Men
dc.contributor.authorSaccà, MLen
dc.contributor.authorSanders, Men
dc.contributor.authorStraub, JOen
dc.contributor.authorTerry, Aen
dc.contributor.authorThomas, Den
dc.contributor.authorToovey, Sen
dc.contributor.authorTownsend, Ren
dc.contributor.authorVoulvoulis, Nen
dc.contributor.authorWatts, Cen
dc.date.accessioned2017-05-17T08:49:25Z
dc.date.available2017-05-17T08:49:25Z
dc.date.issued2008-11en
dc.identifier.issn0091-6765en
dc.identifier.urihttp://hdl.handle.net/10026.1/9264
dc.description.abstract

On 3 October 2007, 40 participants with diverse expertise attended the workshop Tamiflu and the Environment: Implications of Use under Pandemic Conditions to assess the potential human health impact and environmental hazards associated with use of Tamiflu during an influenza pandemic. Based on the identification and risk-ranking of knowledge gaps, the consensus was that oseltamivir ethylester-phosphate (OE-P) and oseltamivir carboxylate (OC) were unlikely to pose an ecotoxicologic hazard to freshwater organisms. OC in river water might hasten the generation of OC-resistance in wildfowl, but this possibility seems less likely than the potential disruption that could be posed by OC and other pharmaceuticals to the operation of sewage treatment plants. The work-group members agreed on the following research priorities: a) available data on the ecotoxicology of OE-P and OC should be published; b) risk should be assessed for OC-contaminated river water generating OC-resistant viruses in wildfowl; c) sewage treatment plant functioning due to microbial inhibition by neuraminidase inhibitors and other antimicrobials used during a pandemic should be investigated; and d) realistic worst-case exposure scenarios should be developed. Additional modeling would be useful to identify localized areas within river catchments that might be prone to high pharmaceutical concentrations in sewage treatment plant effluent. Ongoing seasonal use of Tamiflu in Japan offers opportunities for researchers to assess how much OC enters and persists in the aquatic environment.

en
dc.format.extent1563 - 1567en
dc.languageengen
dc.language.isoengen
dc.subjectTamifluen
dc.subjectantiviralen
dc.subjectdrugen
dc.subjectecotoxicologyen
dc.subjectinfluenzaen
dc.subjectpandemicen
dc.subjectpharmaceuticalen
dc.subjectpollutionen
dc.subjectsewage treatment planten
dc.subjectHumansen
dc.subjectInfluenza, Humanen
dc.subjectOseltamiviren
dc.subjectRisk Assessmenten
dc.titleMeeting report: risk assessment of tamiflu use under pandemic conditions.en
dc.typeJournal Article
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/19057712en
plymouth.issue11en
plymouth.volume116en
plymouth.publication-statusPublisheden
plymouth.journalEnviron Health Perspecten
dc.identifier.doi10.1289/ehp.11310en
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/00 Groups by role
plymouth.organisational-group/Plymouth/00 Groups by role/Academics
plymouth.organisational-group/Plymouth/Faculty of Science and Engineering
plymouth.organisational-group/Plymouth/Faculty of Science and Engineering/School of Geography, Earth and Environmental Sciences
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA06 Agriculture, Veterinary and Food Science
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/BEACh
dc.publisher.placeUnited Statesen
dcterms.dateAccepted2008-05-30en
dc.rights.embargoperiodNot knownen
rioxxterms.versionofrecord10.1289/ehp.11310en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2008-11en
rioxxterms.typeJournal Article/Reviewen


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