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dc.contributor.authorHutchinson, THen
dc.contributor.authorBrown, Ren
dc.contributor.authorBrugger, KEen
dc.contributor.authorCampbell, PMen
dc.contributor.authorHolt, Men
dc.contributor.authorLänge, Ren
dc.contributor.authorMcCahon, Pen
dc.contributor.authorTattersfield, LJen
dc.contributor.authorvan Egmond, Ren
dc.date.accessioned2017-05-17T08:47:35Z
dc.date.available2017-05-17T08:47:35Z
dc.date.issued2000-11en
dc.identifier.issn0091-6765en
dc.identifier.urihttp://hdl.handle.net/10026.1/9260
dc.description.abstract

The European Centre for Ecotoxicology and Toxicology of Chemicals proposes a tiered approach for the ecological risk assessment of endocrine disruptors, integrating exposure and hazard (effects) characterization. Exposure assessment for endocrine disruptors should direct specific tests for wildlife species, placing hazard data into a risk assessment context. Supplementing the suite of mammalian screens now under Organization for Economic Cooperation and Development (OECD) validation, high priority should be given to developing a fish screening assay for detecting endocrine activity in oviparous species. Taking into account both exposure characterization and alerts from endocrine screening, higher tier tests are also a priority for defining adverse effects. We propose that in vivo mammalian and fish assays provide a comprehensive screening battery for diverse hormonal functions (including androgen, estrogen, and thyroid hormone), whereas Amphibia should be considered at higher tiers if there are exposure concerns. Higher tier endocrine-disruptor testing should include fish development and fish reproduction tests, whereas a full life-cycle test could be subsequently used to refine aquatic risk assessments when necessary. For avian risk assessment, the new OECD Japanese quail reproduction test guideline provides a valuable basis for developing a test to detecting endocrine-mediated reproductive effects; this species could be used, where necessary, for an avian life-cycle test. For aquatic and terrestrial invertebrates, data from existing developmental and reproductive tests remain of high value for ecological risk assessment. High priority should be given to research into comparative endocrine physiology of invertebrates to support data extrapolation to this diverse fauna.

en
dc.format.extent1007 - 1014en
dc.languageengen
dc.language.isoengen
dc.subjectAmphibiansen
dc.subjectAnimalsen
dc.subjectAnimals, Wilden
dc.subjectEcosystemen
dc.subjectEndocrine Glandsen
dc.subjectEnvironmental Healthen
dc.subjectEnvironmental Monitoringen
dc.subjectEnvironmental Pollutantsen
dc.subjectFemaleen
dc.subjectFishesen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectMammalsen
dc.subjectRisk Assessmenten
dc.titleEcological risk assessment of endocrine disruptors.en
dc.typeJournal Article
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/11102288en
plymouth.issue11en
plymouth.volume108en
plymouth.publication-statusPublisheden
plymouth.journalEnviron Health Perspecten
dc.identifier.doi10.1289/ehp.001081007en
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/00 Groups by role
plymouth.organisational-group/Plymouth/00 Groups by role/Academics
plymouth.organisational-group/Plymouth/Faculty of Science and Engineering
plymouth.organisational-group/Plymouth/Faculty of Science and Engineering/School of Geography, Earth and Environmental Sciences
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA06 Agriculture, Veterinary and Food Science
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/BEACh
dc.publisher.placeUnited Statesen
dc.rights.embargoperiodNot knownen
rioxxterms.versionofrecord10.1289/ehp.001081007en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.typeJournal Article/Reviewen


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