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dc.contributor.authorCrane, HM
dc.contributor.authorPickford, DB
dc.contributor.authorHutchinson, TH
dc.contributor.authorBrown, JA
dc.date.accessioned2017-05-17T08:46:38Z
dc.date.available2017-05-17T08:46:38Z
dc.date.issued2005-04
dc.identifier.issn0091-6765
dc.identifier.issn1552-9924
dc.identifier.urihttp://hdl.handle.net/10026.1/9258
dc.description.abstract

Perchlorate is a known environmental contaminant, largely due to widespread military use as a propellant. Perchlorate acts pharmacologically as a competitive inhibitor of thyroidal iodide uptake in mammals, but the impacts of perchlorate contamination in aquatic ecosystems and, in particular, the effects on fish are unclear. Our studies aimed to investigate the effects of concentrations of ammonium perchlorate that can occur in the environment (1, 10, and 100 mg/L) on the development of fathead minnows, Pimephales promelas. For these studies, exposures started with embryos of < 24-hr postfertilization and were terminated after 28 days. Serial sectioning of thyroid follicles showed thyroid hyperplasia with increased follicular epithelial cell height and reduced colloid in all groups of fish that had been exposed to perchlorate for 28 days, compared with control fish. Whole-body thyroxine (T4) content (a measure of total circulating T4 in fish exposed to 100 mg/L perchlorate was elevated compared with the T4 content of control fish, but 3,5,3-triiodothyronine (T3) content was not significantly affected in any exposure group. Despite the apparent regulation of T3, after 28 days of exposure to ammonium perchlorate, fish exposed to the two higher levels (10 and 100 mg/L) were developmentally retarded, with a lack of scales and poor pigmentation, and significantly lower wet weight and standard length than were control fish. Our study indicates that environmental levels of ammonium perchlorate affect thyroid function in fish and that in the early life stages these effects may be associated with developmental retardation.

dc.format.extent396-401
dc.format.mediumPrint
dc.languageen
dc.language.isoeng
dc.publisherEnvironmental Health Perspectives
dc.subjectdevelopment
dc.subjectendocrine disruption
dc.subjectfathead minnow
dc.subjectperchlorate
dc.subjectthyroid
dc.subjectthyroxine
dc.subjecttriiodothyronine
dc.titleEffects of Ammonium Perchlorate on Thyroid Function in Developing Fathead Minnows, <i>Pimephales promelas</i>
dc.typejournal-article
dc.typeArticle
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/15811828
plymouth.issue4
plymouth.volume113
plymouth.publisher-urlhttp://dx.doi.org/10.1289/ehp.7333
plymouth.publication-statusPublished
plymouth.journalEnvironmental Health Perspectives
dc.identifier.doi10.1289/ehp.7333
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/BEACh
plymouth.organisational-group/Plymouth/Users by role
dc.publisher.placeUnited States
dc.identifier.eissn1552-9924
dc.rights.embargoperiodNot known
rioxxterms.versionofrecord10.1289/ehp.7333
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.typeJournal Article/Review


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