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dc.contributor.authorKarimkhani, C
dc.contributor.authorTrikha, R
dc.contributor.authorAksut, B
dc.contributor.authorJones, T
dc.contributor.authorBoyers, LN
dc.contributor.authorSchlichte, M
dc.contributor.authorPederson, H
dc.contributor.authorOkland, T
dc.contributor.authorDiGuiseppi, C
dc.contributor.authorNasser, M
dc.contributor.authorNaghavi, M
dc.contributor.authorVos, T
dc.contributor.authorYoong, SL
dc.contributor.authorWolfenden, L
dc.contributor.authorMurray, CJ
dc.contributor.authorDellavalle, RP
dc.date.accessioned2017-04-28T08:44:46Z
dc.date.available2017-04-28T08:44:46Z
dc.date.issued2016-05-01
dc.identifier.issn0020-1383
dc.identifier.issn1879-0267
dc.identifier.urihttp://hdl.handle.net/10026.1/9159
dc.description.abstract

Burden of disease should impact research prioritisation.To analyse the Cochrane Database of Systematic Reviews (CDSR) and determine whether systematic reviews and protocols accurately represent disease burden, as measured by disability-adjusted life years (DALYs) from the Global Burden of Disease (GBD) 2010 Study.Two investigators collected GBD disability metrics for 12 external causes of injury in the GBD 2010 Study. These external causes were then assessed for systematic review and protocol representation in CDSR. Data was collected during the month of April 2015. There were no study participants aside from the researchers. Percentage of total 2010 DALYs, 2010 DALY rank, and median DALY percent change from 1990 to 2010 of the 12 external causes of injury were compared with CDSR representation of systematic reviews and protocols. Data were analysed for correlation using Spearman rank correlation.Eleven of the 12 causes were represented by at least one systematic review or protocol in CDSR; the category collective violence and legal intervention had no representation in CDSR. Correlation testing revealed a strong positive correlation that was statistically significant. Representation of road injury; interpersonal violence; fire, heat, and hot substances; mechanical forces; poisonings, adverse effect of medical treatment, and animal contact was well aligned with respect to DALY. Representation of falls was greater compared to DALY, while self-harm, exposure to forces of nature, and other transport injury representation was lower compared to DALY.CDSR representation of external causes of injury strongly correlates with disease burden. The number of systematic reviews and protocols was well aligned for seven out of 12 causes of injury. These results provide high-quality and transparent data that may guide future prioritisation decisions.

dc.format.extent1151-1157
dc.format.mediumPrint-Electronic
dc.languageen
dc.language.isoen
dc.publisherElsevier BV
dc.subjectBurden of disease
dc.subjectDALY
dc.subjectEpidemiology
dc.subjectInjury
dc.subjectTrauma
dc.subjectDisability
dc.subjectSystematic review
dc.subjectCochrane
dc.titleIdentifying gaps for research prioritisation: Global burden of external causes of injury as reflected in the Cochrane Database of Systematic Reviews.
dc.typejournal-article
dc.typeArticle
dc.typeProceedings Paper
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/26804937
plymouth.issue5
plymouth.volume47
plymouth.publisher-urlhttp://dx.doi.org/10.1016/j.injury.2015.12.019
plymouth.publication-statusPublished
plymouth.journalInjury
dc.identifier.doi10.1016/j.injury.2015.12.019
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Admin Group - REF
plymouth.organisational-group/Plymouth/Admin Group - REF/REF Admin Group - FoH
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Faculty of Health/Peninsula Dental School
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/Institute of Health and Community
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CCT&PS
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
dc.publisher.placeNetherlands
dcterms.dateAccepted2015-12-19
dc.identifier.eissn1879-0267
dc.rights.embargoperiodNo embargo
rioxxterms.versionofrecord10.1016/j.injury.2015.12.019
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2016-05-01
rioxxterms.typeJournal Article/Review
plymouth.oa-locationhttp://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4862959&blobtype=pdf


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