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dc.contributor.authorMill, R
dc.contributor.authorCoath, Martin
dc.contributor.authorWennekers, Thomas
dc.contributor.authordenham, susan
dc.date.accessioned2017-02-13T13:58:29Z
dc.date.available2017-02-13T13:58:29Z
dc.date.issued2011-08-18
dc.identifier.issn1553-734X
dc.identifier.issn1553-7358
dc.identifier.otherARTN e1002117
dc.identifier.urihttp://hdl.handle.net/10026.1/8458
dc.description.abstract

Stimulus-specific adaptation (SSA) occurs when the spike rate of a neuron decreases with repetitions of the same stimulus, but recovers when a different stimulus is presented. It has been suggested that SSA in single auditory neurons may provide information to change detection mechanisms evident at other scales (e.g., mismatch negativity in the event related potential), and participate in the control of attention and the formation of auditory streams. This article presents a spiking-neuron model that accounts for SSA in terms of the convergence of depressing synapses that convey feature-specific inputs. The model is anatomically plausible, comprising just a few homogeneously connected populations, and does not require organised feature maps. The model is calibrated to match the SSA measured in the cortex of the awake rat, as reported in one study. The effect of frequency separation, deviant probability, repetition rate and duration upon SSA are investigated. With the same parameter set, the model generates responses consistent with a wide range of published data obtained in other auditory regions using other stimulus configurations, such as block, sequential and random stimuli. A new stimulus paradigm is introduced, which generalises the oddball concept to Markov chains, allowing the experimenter to vary the tone probabilities and the rate of switching independently. The model predicts greater SSA for higher rates of switching. Finally, the issue of whether rarity or novelty elicits SSA is addressed by comparing the responses of the model to deviants in the context of a sequence of a single standard or many standards. The results support the view that synaptic adaptation alone can explain almost all aspects of SSA reported to date, including its purported novelty component, and that non-trivial networks of depressing synapses can intensify this novelty response.

dc.format.extente1002117-
dc.format.mediumPrint-Electronic
dc.languageeng
dc.language.isoeng
dc.publisherPublic Library of Science (PLoS)
dc.subjectAcoustic Stimulation
dc.subjectAdaptation, Physiological
dc.subjectAnimals
dc.subjectAuditory Cortex
dc.subjectComputational Biology
dc.subjectEvoked Potentials, Auditory
dc.subjectMarkov Chains
dc.subjectModels, Neurological
dc.subjectNeurons
dc.subjectRats
dc.subjectSynapses
dc.subjectWakefulness
dc.titleA neurocomputational model of stimulus-specific adaptation to oddball and Markov sequences.
dc.typejournal-article
dc.typeArticle
plymouth.author-urlhttp://www.ncbi.nlm.nih.gov/pubmed/21876661
plymouth.issue8
plymouth.volume7
plymouth.publication-statusPublished online
plymouth.journalPLoS Comput Biol
dc.identifier.doi10.1371/journal.pcbi.1002117
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Admin Group - REF
plymouth.organisational-group/Plymouth/Admin Group - REF/REF Admin Group - FoSE
plymouth.organisational-group/Plymouth/Faculty of Science and Engineering
plymouth.organisational-group/Plymouth/Faculty of Science and Engineering/School of Engineering, Computing and Mathematics
plymouth.organisational-group/Plymouth/PS - Doctoral College
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA04 Psychology, Psychiatry and Neuroscience
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA11 Computer Science and Informatics
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/Centre for Brain, Cognition and Behaviour (CBCB)
plymouth.organisational-group/Plymouth/Research Groups/Centre for Brain, Cognition and Behaviour (CBCB)/Brain
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
dc.publisher.placeUnited States
dcterms.dateAccepted2011-05-24
dc.identifier.eissn1553-7358
dc.rights.embargoperiodNot known
rioxxterms.versionofrecord10.1371/journal.pcbi.1002117
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.typeJournal Article/Review


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