The Transcriptional Landscape of the Photosynthetic Model Cyanobacterium Synechocystis sp. PCC6803
dc.contributor.author | Hernández-Prieto, MA | |
dc.contributor.author | Semeniuk, TA | |
dc.contributor.author | Giner-Lamia, J | |
dc.contributor.author | Futschik, Matthias | |
dc.date.accessioned | 2017-02-07T20:10:51Z | |
dc.date.available | 2017-02-07T20:10:51Z | |
dc.date.issued | 2016-02-29 | |
dc.identifier.issn | 2045-2322 | |
dc.identifier.issn | 2045-2322 | |
dc.identifier.other | 22168 | |
dc.identifier.uri | http://hdl.handle.net/10026.1/8420 | |
dc.description.abstract |
<jats:title>Abstract</jats:title><jats:p>Cyanobacteria exhibit a great capacity to adapt to different environmental conditions through changes in gene expression. Although this plasticity has been extensively studied in the model cyanobacterium <jats:italic>Synechocystis</jats:italic> sp. PCC 6803, a detailed analysis of the coordinated transcriptional adaption across varying conditions is lacking. Here, we report a meta-analysis of 756 individual microarray measurements conducted in 37 independent studies-the most comprehensive study of the <jats:italic>Synechocystis</jats:italic> transcriptome to date. Using stringent statistical evaluation, we characterized the coordinated adaptation of <jats:italic>Synechocystis</jats:italic>’ gene expression on systems level. Evaluation of the data revealed that the photosynthetic apparatus is subjected to greater changes in expression than other cellular components. Nevertheless, network analyses indicated a significant degree of transcriptional coordination of photosynthesis and various metabolic processes, and revealed the tight co-regulation of components of photosystems I, II and phycobilisomes. Detailed inspection of the integrated data led to the discovery a variety of regulatory patterns and novel putative photosynthetic genes. Intriguingly, global clustering analyses suggested contrasting transcriptional response of metabolic and regulatory genes stress to conditions. The integrated <jats:italic>Synechocystis</jats:italic> transcriptome can be accessed and interactively analyzed via the CyanoEXpress website (<jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://cyanoexpress.sysbiolab.eu">http://cyanoexpress.sysbiolab.eu</jats:ext-link>).</jats:p> | |
dc.format.extent | 22168- | |
dc.format.medium | Electronic | |
dc.language | en | |
dc.language.iso | eng | |
dc.publisher | Springer Science and Business Media LLC | |
dc.subject | Cluster Analysis | |
dc.subject | Computational Biology | |
dc.subject | Databases, Genetic | |
dc.subject | Gene Expression Profiling | |
dc.subject | Gene Expression Regulation, Bacterial | |
dc.subject | Gene-Environment Interaction | |
dc.subject | Photosynthesis | |
dc.subject | Synechocystis | |
dc.subject | Transcriptome | |
dc.title | The Transcriptional Landscape of the Photosynthetic Model Cyanobacterium Synechocystis sp. PCC6803 | |
dc.type | journal-article | |
dc.type | Journal Article | |
dc.type | Research Support, Non-U.S. Gov't | |
plymouth.author-url | https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000371108100001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008 | |
plymouth.issue | 1 | |
plymouth.volume | 6 | |
plymouth.publication-status | Published online | |
plymouth.journal | Scientific Reports | |
dc.identifier.doi | 10.1038/srep22168 | |
plymouth.organisational-group | /Plymouth | |
plymouth.organisational-group | /Plymouth/Faculty of Health | |
plymouth.organisational-group | /Plymouth/Users by role | |
dc.publisher.place | England | |
dcterms.dateAccepted | 2016-02-09 | |
dc.identifier.eissn | 2045-2322 | |
dc.rights.embargoperiod | Not known | |
rioxxterms.versionofrecord | 10.1038/srep22168 | |
rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
rioxxterms.licenseref.startdate | 2016-02-29 | |
rioxxterms.type | Journal Article/Review |