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dc.contributor.authorHernández-Prieto, MA
dc.contributor.authorSemeniuk, TA
dc.contributor.authorGiner-Lamia, J
dc.contributor.authorFutschik, Matthias
dc.date.accessioned2017-02-07T20:10:51Z
dc.date.available2017-02-07T20:10:51Z
dc.date.issued2016-02-29
dc.identifier.issn2045-2322
dc.identifier.issn2045-2322
dc.identifier.other22168
dc.identifier.urihttp://hdl.handle.net/10026.1/8420
dc.description.abstract

<jats:title>Abstract</jats:title><jats:p>Cyanobacteria exhibit a great capacity to adapt to different environmental conditions through changes in gene expression. Although this plasticity has been extensively studied in the model cyanobacterium <jats:italic>Synechocystis</jats:italic> sp. PCC 6803, a detailed analysis of the coordinated transcriptional adaption across varying conditions is lacking. Here, we report a meta-analysis of 756 individual microarray measurements conducted in 37 independent studies-the most comprehensive study of the <jats:italic>Synechocystis</jats:italic> transcriptome to date. Using stringent statistical evaluation, we characterized the coordinated adaptation of <jats:italic>Synechocystis</jats:italic>’ gene expression on systems level. Evaluation of the data revealed that the photosynthetic apparatus is subjected to greater changes in expression than other cellular components. Nevertheless, network analyses indicated a significant degree of transcriptional coordination of photosynthesis and various metabolic processes, and revealed the tight co-regulation of components of photosystems I, II and phycobilisomes. Detailed inspection of the integrated data led to the discovery a variety of regulatory patterns and novel putative photosynthetic genes. Intriguingly, global clustering analyses suggested contrasting transcriptional response of metabolic and regulatory genes stress to conditions. The integrated <jats:italic>Synechocystis</jats:italic> transcriptome can be accessed and interactively analyzed via the CyanoEXpress website (<jats:ext-link xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="uri" xlink:href="http://cyanoexpress.sysbiolab.eu">http://cyanoexpress.sysbiolab.eu</jats:ext-link>).</jats:p>

dc.format.extent22168-
dc.format.mediumElectronic
dc.languageen
dc.language.isoeng
dc.publisherSpringer Science and Business Media LLC
dc.subjectCluster Analysis
dc.subjectComputational Biology
dc.subjectDatabases, Genetic
dc.subjectGene Expression Profiling
dc.subjectGene Expression Regulation, Bacterial
dc.subjectGene-Environment Interaction
dc.subjectPhotosynthesis
dc.subjectSynechocystis
dc.subjectTranscriptome
dc.titleThe Transcriptional Landscape of the Photosynthetic Model Cyanobacterium Synechocystis sp. PCC6803
dc.typejournal-article
dc.typeJournal Article
dc.typeResearch Support, Non-U.S. Gov't
plymouth.author-urlhttps://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000371108100001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008
plymouth.issue1
plymouth.volume6
plymouth.publication-statusPublished online
plymouth.journalScientific Reports
dc.identifier.doi10.1038/srep22168
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Users by role
dc.publisher.placeEngland
dcterms.dateAccepted2016-02-09
dc.identifier.eissn2045-2322
dc.rights.embargoperiodNot known
rioxxterms.versionofrecord10.1038/srep22168
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2016-02-29
rioxxterms.typeJournal Article/Review


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