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dc.contributor.authorPinto, JP
dc.contributor.authorReddy Kalathur, RK
dc.contributor.authorMachado, RSR
dc.contributor.authorXavier, JM
dc.contributor.authorBragança, J
dc.contributor.authorFutschik, Matthias
dc.date.accessioned2017-02-07T20:04:40Z
dc.date.available2017-02-07T20:04:40Z
dc.date.issued2014-07-01
dc.identifier.issn0305-1048
dc.identifier.issn1362-4962
dc.identifier.urihttp://hdl.handle.net/10026.1/8417
dc.description.abstract

Stem cells are characterized by their potential for self-renewal and their capacity to differentiate into mature cells. These two key features emerge through the interplay of various factors within complex molecular networks. To provide researchers with a dedicated tool to investigate these networks, we have developed StemCellNet, a versatile web server for interactive network analysis and visualization. It rapidly generates focused networks based on a large collection of physical and regulatory interactions identified in human and murine stem cells. The StemCellNet web-interface has various easy-to-use tools for selection and prioritization of network components, as well as for integration of expression data provided by the user. As a unique feature, the networks generated can be screened against a compendium of stemness-associated genes. StemCellNet can also indicate novel candidate genes by evaluating their connectivity patterns. Finally, an optional dataset of generic interactions, which provides large coverage of the human and mouse proteome, extends the versatility of StemCellNet to other biomedical research areas in which stem cells play important roles, such as in degenerative diseases or cancer. The StemCellNet web server is freely accessible at http://stemcellnet.sysbiolab.eu.

dc.format.extentW154-W160
dc.format.mediumPrint-Electronic
dc.languageen
dc.language.isoeng
dc.publisherOxford University Press (OUP)
dc.subjectAnimals
dc.subjectGene Expression
dc.subjectGene Regulatory Networks
dc.subjectHumans
dc.subjectInternet
dc.subjectMice
dc.subjectProtein Interaction Mapping
dc.subjectProteome
dc.subjectSoftware
dc.subjectStem Cells
dc.titleStemCellNet: an interactive platform for network-oriented investigations in stem cell biology
dc.typejournal-article
dc.typeJournal Article
dc.typeResearch Support, Non-U.S. Gov't
plymouth.author-urlhttps://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000339715000026&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008
plymouth.issueW1
plymouth.volume42
plymouth.publication-statusPublished
plymouth.journalNucleic Acids Research
dc.identifier.doi10.1093/nar/gku455
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Users by role
dc.publisher.placeEngland
dc.identifier.eissn1362-4962
dc.rights.embargoperiodNot known
rioxxterms.versionofrecord10.1093/nar/gku455
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.typeJournal Article/Review


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