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dc.contributor.authorKalathur, RKR
dc.contributor.authorPinto, JP
dc.contributor.authorHernández-Prieto, MA
dc.contributor.authorMachado, RSR
dc.contributor.authorAlmeida, D
dc.contributor.authorChaurasia, G
dc.contributor.authorFutschik, Matthias
dc.date.accessioned2017-02-07T20:04:19Z
dc.date.available2017-02-07T20:04:19Z
dc.date.issued2014-01
dc.identifier.issn0305-1048
dc.identifier.issn1362-4962
dc.identifier.urihttp://hdl.handle.net/10026.1/8416
dc.description.abstract

Unified Human Interactome (UniHI) (http://www.unihi.org) is a database for retrieval, analysis and visualization of human molecular interaction networks. Its primary aim is to provide a comprehensive and easy-to-use platform for network-based investigations to a wide community of researchers in biology and medicine. Here, we describe a major update (version 7) of the database previously featured in NAR Database Issue. UniHI 7 currently includes almost 350,000 molecular interactions between genes, proteins and drugs, as well as numerous other types of data such as gene expression and functional annotation. Multiple options for interactive filtering and highlighting of proteins can be employed to obtain more reliable and specific network structures. Expression and other genomic data can be uploaded by the user to examine local network structures. Additional built-in tools enable ready identification of known drug targets, as well as of biological processes, phenotypes and pathways enriched with network proteins. A distinctive feature of UniHI 7 is its user-friendly interface designed to be utilized in an intuitive manner, enabling researchers less acquainted with network analysis to perform state-of-the-art network-based investigations.

dc.format.extentD408-D414
dc.format.mediumPrint-Electronic
dc.languageen
dc.language.isoeng
dc.publisherOxford University Press (OUP)
dc.subjectDatabases, Protein
dc.subjectDisease
dc.subjectGene Expression
dc.subjectGenes
dc.subjectGenomics
dc.subjectHumans
dc.subjectInternet
dc.subjectMolecular Sequence Annotation
dc.subjectPharmaceutical Preparations
dc.subjectPhenotype
dc.subjectProtein Interaction Mapping
dc.subjectProteins
dc.titleUniHI 7: an enhanced database for retrieval and interactive analysis of human molecular interaction networks
dc.typejournal-article
dc.typeJournal Article
dc.typeResearch Support, Non-U.S. Gov't
plymouth.author-urlhttps://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000331139800061&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008
plymouth.issueD1
plymouth.volume42
plymouth.publication-statusPublished
plymouth.journalNucleic Acids Research
dc.identifier.doi10.1093/nar/gkt1100
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Users by role
dc.publisher.placeEngland
dc.identifier.eissn1362-4962
dc.rights.embargoperiodNot known
rioxxterms.versionofrecord10.1093/nar/gkt1100
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.typeJournal Article/Review


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