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dc.contributor.authorChaurasia, G
dc.contributor.authorMalhotra, S
dc.contributor.authorRuss, J
dc.contributor.authorSchnoegl, S
dc.contributor.authorHänig, C
dc.contributor.authorWanker, EE
dc.contributor.authorFutschik, ME
dc.date.accessioned2017-02-07T19:50:10Z
dc.date.available2017-02-07T19:50:10Z
dc.date.issued2009-01
dc.identifier.issn0305-1048
dc.identifier.issn1362-4962
dc.identifier.urihttp://hdl.handle.net/10026.1/8408
dc.description.abstract

Human protein interaction maps have become important tools of biomedical research for the elucidation of molecular mechanisms and the identification of new modulators of disease processes. The Unified Human Interactome database (UniHI, http://www.unihi.org) provides researchers with a comprehensive platform to query and access human protein-protein interaction (PPI) data. Since its first release, UniHI has considerably increased in size. The latest update of UniHI includes over 250,000 interactions between approximately 22,300 unique proteins collected from 14 major PPI sources. However, this wealth of data also poses new challenges for researchers due to the complexity of interaction networks retrieved from the database. We therefore developed several new tools to query, analyze and visualize human PPI networks. Most importantly, UniHI allows now the construction of tissue-specific interaction networks and focused querying of canonical pathways. This will enable researchers to target their analysis and to prioritize candidate proteins for follow-up studies.

dc.format.extentD657-D660
dc.format.mediumPrint-Electronic
dc.languageen
dc.language.isoeng
dc.publisherOxford University Press (OUP)
dc.subjectComputer Graphics
dc.subjectDatabases, Protein
dc.subjectHumans
dc.subjectProtein Interaction Mapping
dc.subjectProteins
dc.subjectSoftware
dc.subjectUser-Computer Interface
dc.titleUniHI 4: new tools for query, analysis and visualization of the human protein–protein interactome
dc.typejournal-article
dc.typeArticle
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/18984619
plymouth.issuesuppl_1
plymouth.volume37
plymouth.publisher-urlhttp://dx.doi.org/10.1093/nar/gkn841
plymouth.publication-statusPublished
plymouth.journalNucleic Acids Research
dc.identifier.doi10.1093/nar/gkn841
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Users by role
dc.publisher.placeEngland
dc.identifier.eissn1362-4962
dc.rights.embargoperiodNot known
rioxxterms.versionofrecord10.1093/nar/gkn841
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.typeJournal Article/Review


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