UniHI 4: new tools for query, analysis and visualization of the human protein-protein interactome.
MetadataShow full item record
Human protein interaction maps have become important tools of biomedical research for the elucidation of molecular mechanisms and the identification of new modulators of disease processes. The Unified Human Interactome database (UniHI, http://www.unihi.org) provides researchers with a comprehensive platform to query and access human protein-protein interaction (PPI) data. Since its first release, UniHI has considerably increased in size. The latest update of UniHI includes over 250,000 interactions between approximately 22,300 unique proteins collected from 14 major PPI sources. However, this wealth of data also poses new challenges for researchers due to the complexity of interaction networks retrieved from the database. We therefore developed several new tools to query, analyze and visualize human PPI networks. Most importantly, UniHI allows now the construction of tissue-specific interaction networks and focused querying of canonical pathways. This will enable researchers to target their analysis and to prioritize candidate proteins for follow-up studies.
Place of Publication
The following license files are associated with this item:
Showing items related by title, author, creator and subject.
Regulation of multiple angiogenic pathways by Dll4 and Notch in human umbilical vein endothelial cells. Harrington, LS; Sainson, RCA; Williams, CK; Taylor, JM; Shi, W; Li, J-L; Harris, AL (United States, 2008-03)The Notch ligand, Dll4, is essential for angiogenesis during embryonic vascular development and is involved in tumour angiogenesis. Several recent publications demonstrated that blockade of Dll4 signalling inhibits tumour ...
Radakovits, R; Barros, CS; Belvindrah, R; Patton, B; Müller, U (United States, 2009-06-17)Radial glial cells (RGCs) in the developing cerebral cortex are progenitors for neurons and glia, and their processes serve as guideposts for migrating neurons. So far, it has remained unclear whether RGC processes also ...
Exposito-Rodriguez, M; Laissue, PP; Littlejohn, GR; Smirnoff, N; Mullineaux, PM (United States, 2013)Exposure of photosynthetic cells of leaf tissues of Arabidopsis thaliana (Arabidopsis) to high light intensities (HL) may provoke a rapid rise in hydrogen peroxide (H2O2) levels in chloroplasts and subcellular compartments, ...