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dc.contributor.authorChaurasia, G
dc.contributor.authorIqbal, Y
dc.contributor.authorHänig, C
dc.contributor.authorHerzel, H
dc.contributor.authorWanker, EE
dc.contributor.authorFutschik, Matthias
dc.date.accessioned2017-02-07T19:48:38Z
dc.date.available2017-02-07T19:48:38Z
dc.date.issued2007-01
dc.identifier.issn0305-1048
dc.identifier.issn1362-4962
dc.identifier.urihttp://hdl.handle.net/10026.1/8405
dc.description.abstract

Systematic mapping of protein-protein interactions has become a central task of functional genomics. To map the human interactome, several strategies have recently been pursued. The generated interaction datasets are valuable resources for scientists in biology and medicine. However, comparison reveals limited overlap between different interaction networks. This divergence obstructs usability, as researchers have to interrogate numerous heterogeneous datasets to identify potential interaction partners for proteins of interest. To facilitate direct access through a single entry gate, we have started to integrate currently available human protein interaction data in an easily accessible online database. It is called UniHI (Unified Human Interactome) and is available at http://www.mdc-berlin.de/unihi. At present, it is based on 10 major interaction maps derived by computational and experimental methods. It includes more than 150,000 distinct interactions between more than 17 000 unique human proteins. UniHI provides researchers with a flexible integrated tool for finding and using comprehensive information about the human interactome.

dc.format.extentD590-D594
dc.format.mediumPrint-Electronic
dc.languageen
dc.language.isoeng
dc.publisherOxford University Press (OUP)
dc.subjectComputer Graphics
dc.subjectDatabases, Protein
dc.subjectHumans
dc.subjectInternet
dc.subjectProtein Interaction Mapping
dc.subjectSystems Integration
dc.subjectUser-Computer Interface
dc.titleUniHI: an entry gate to the human protein interactome
dc.typejournal-article
dc.typeJournal Article
dc.typeResearch Support, Non-U.S. Gov't
plymouth.author-urlhttps://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000243494600118&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008
plymouth.issuesuppl_1
plymouth.volume35
plymouth.publication-statusPublished
plymouth.journalNucleic Acids Research
dc.identifier.doi10.1093/nar/gkl817
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Users by role
dc.publisher.placeEngland
dc.identifier.eissn1362-4962
dc.rights.embargoperiodNot known
rioxxterms.versionofrecord10.1093/nar/gkl817
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.typeJournal Article/Review


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