Model selection and efficiency testing for normalization of cDNA microarray
dc.contributor.author | Futschik, Matthias | |
dc.contributor.author | Crompton, T | |
dc.date.accessioned | 2017-02-06T11:20:47Z | |
dc.date.available | 2017-02-06T11:20:47Z | |
dc.date.issued | 2004-07-30 | |
dc.identifier.issn | 1465-6906 | |
dc.identifier.issn | 1474-760X | |
dc.identifier.other | ARTN R60 | |
dc.identifier.uri | http://hdl.handle.net/10026.1/8354 | |
dc.description.abstract |
In this study we present two novel normalization schemes for cDNA microarrays. They are based on iterative local regression and optimization of model parameters by generalized cross-validation. Permutation tests assessing the efficiency of normalization demonstrated that the proposed schemes have an improved ability to remove systematic errors and to reduce variability in microarray data. The analysis also reveals that without parameter optimization local regression is frequently insufficient to remove systematic errors in microarray data. | |
dc.format.extent | R60-R60 | |
dc.format.medium | Print-Electronic | |
dc.language | eng | |
dc.language.iso | en | |
dc.publisher | Springer Nature | |
dc.subject | Algorithms | |
dc.subject | Bias | |
dc.subject | Cell Line, Tumor | |
dc.subject | Colonic Neoplasms | |
dc.subject | Coloring Agents | |
dc.subject | DNA, Complementary | |
dc.subject | Fibroblasts | |
dc.subject | Gene Expression Profiling | |
dc.subject | Humans | |
dc.subject | Lymphatic Metastasis | |
dc.subject | Male | |
dc.subject | Middle Aged | |
dc.subject | Nucleic Acid Hybridization | |
dc.subject | Oligonucleotide Array Sequence Analysis | |
dc.subject | RNA, Messenger | |
dc.subject | Reference Standards | |
dc.subject | Reproducibility of Results | |
dc.subject | Research Design | |
dc.title | Model selection and efficiency testing for normalization of cDNA microarray | |
dc.type | journal-article | |
dc.type | Journal Article | |
plymouth.author-url | https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000223061200016&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008 | |
plymouth.issue | 8 | |
plymouth.volume | 5 | |
plymouth.publication-status | Published | |
plymouth.journal | Genome Biology | |
dc.identifier.doi | 10.1186/gb-2004-5-8-r60 | |
plymouth.organisational-group | /Plymouth | |
plymouth.organisational-group | /Plymouth/Faculty of Health | |
plymouth.organisational-group | /Plymouth/Users by role | |
dc.publisher.place | England | |
dcterms.dateAccepted | 2004-06-28 | |
dc.identifier.eissn | 1474-760X | |
dc.rights.embargoperiod | Not known | |
rioxxterms.versionofrecord | 10.1186/gb-2004-5-8-r60 | |
rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
rioxxterms.licenseref.startdate | 2004-07-30 | |
rioxxterms.type | Journal Article/Review |