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dc.contributor.authorDunn, MJ
dc.contributor.authorWiggins, D
dc.contributor.authorWoodhouse, JM
dc.contributor.authorMargrain, TH
dc.contributor.authorHarris, Chris
dc.contributor.authorErichsen, JT
dc.date.accessioned2017-02-03T17:27:18Z
dc.date.available2017-02-03T17:27:18Z
dc.date.issued2017-01-01
dc.identifier.issn1552-5783
dc.identifier.issn1552-5783
dc.identifier.urihttp://hdl.handle.net/10026.1/8350
dc.description.abstract

PURPOSE: Most individuals with infantile nystagmus (IN) have an idiosyncratic gaze angle at which their nystagmus intensity is minimized. Some adopt an abnormal head posture to use this "null zone," and it has therefore long been assumed that this provides people with nystagmus with improved visual acuity (VA). However, recent studies suggest that improving the nystagmus waveform could have little, if any, influence on VA; that is, VA is fundamentally limited in IN. Here, we examined the impact of the null zone on VA. METHODS: Visual acuity was measured in eight adults with IN using a psychophysical staircase procedure with reversals at three horizontal gaze angles, including the null zone. RESULTS: As expected, changes in gaze angle affected nystagmus amplitude, frequency, foveation duration, and variability of intercycle foveation position. Across participants, each parameter (except frequency) was significantly correlated with VA. Within any given individual, there was a small but significant improvement in VA (0.08 logMAR) at the null zone as compared with the other gaze angles tested. Despite this, no change in any of the nystagmus waveform parameters was significantly associated with changes in VA within individuals. CONCLUSIONS: A strong relationship between VA and nystagmus characteristics exists between individuals with IN. Although significant, the improvement in VA observed within individuals at the null zone is much smaller than might be expected from the occasionally large variations in intensity and foveation dynamics (and anecdotal patient reports of improved vision), suggesting that improvement of other aspects of visual performance may also encourage use of the null zone.

dc.format.extent642-642
dc.format.mediumPrint
dc.languageen
dc.language.isoen
dc.publisherAssociation for Research in Vision and Ophthalmology (ARVO)
dc.subjectfoveation
dc.subjectnull zone
dc.subjectpsychophysics
dc.titleThe  effect  of  gaze  angle  on visual acuity in  infantile nystagmus
dc.typejournal-article
dc.typeJournal Article
dc.typeResearch Support, Non-U.S. Gov't
plymouth.author-urlhttps://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000392954300069&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008
plymouth.issue1
plymouth.volume58
plymouth.publication-statusPublished
plymouth.journalInvestigative Ophthamoloy and Visual Science
dc.identifier.doi10.1167/iovs.16-20370
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/Centre for Brain, Cognition and Behaviour (CBCB)
plymouth.organisational-group/Plymouth/Research Groups/Centre for Brain, Cognition and Behaviour (CBCB)/Brain
plymouth.organisational-group/Plymouth/Users by role
dc.publisher.placeUnited States
dcterms.dateAccepted2016-11-22
dc.identifier.eissn1552-5783
dc.rights.embargoperiodNo embargo
rioxxterms.versionofrecord10.1167/iovs.16-20370
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2017-01-01
rioxxterms.typeJournal Article/Review
plymouth.oa-locationhttp://iovs.arvojournals.org/article.aspx?articleid=2600151


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