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dc.contributor.authorSneyd, JR
dc.date.accessioned2017-01-23T10:08:20Z
dc.date.available2017-01-23T10:08:20Z
dc.date.issued2016-12-12
dc.identifier.issn0007-0912
dc.identifier.issn1471-6771
dc.identifier.urihttp://hdl.handle.net/10026.1/8289
dc.description.abstract

Time to move the goalposts? Do we need new targets for developing intravenous anaesthetics? Widespread use of intravenous hypnotics for induction of anaesthesia dates from 1934 when thiopentone was introduced. Since then a handful of agents have come and gone with only propofol and ketamine enjoying common use in addition to some residual administrations of thiopentone and etomidate, During the 30 years since propofol was introduced in 1986, number of candidate hypnotics and propofol reformulations have been evaluated but none have yet achieved commercial success or significant clinical impact. During this period developmental objectives built on the shortfalls of thiopentone listed by Dundee in 1961 with additional ambitions arising from the known limitations of propofol and increasing interest in maintenance of anaesthesia by infusion.

dc.format.extent684-687
dc.format.mediumPrint
dc.languageen
dc.language.isoen
dc.publisherElsevier BV
dc.subjectAnesthetics, Intravenous
dc.subjectDrug Discovery
dc.subjectHumans
dc.titleTime to move the goalposts? Do we need new targets for developing i.v. anaesthetics?
dc.typejournal-article
dc.typeEditorial Material
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/27956665
plymouth.issue6
plymouth.volume117
plymouth.publisher-urlhttp://dx.doi.org/10.1093/bja/aew330
plymouth.publication-statusPublished
plymouth.journalBritish Journal of Anaesthesia
dc.identifier.doi10.1093/bja/aew330
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Users by role
dc.publisher.placeEngland
dcterms.dateAccepted2016-04-01
dc.rights.embargodate2017-12-12
dc.identifier.eissn1471-6771
dc.rights.embargoperiodNo embargo
rioxxterms.versionofrecord10.1093/bja/aew330
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2016-12-12
rioxxterms.typeJournal Article/Review
plymouth.oa-locationhttp://dx.doi.org/10.1093/bja/aew330


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