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dc.contributor.authorWalters, NJen
dc.contributor.authorXia, Wen
dc.contributor.authorSalih, Ven
dc.contributor.authorAshley, PFen
dc.contributor.authorYoung, AMen
dc.date.accessioned2017-01-10T15:55:41Z
dc.date.accessioned2017-01-10T16:21:12Z
dc.date.available2017-01-10T15:55:41Z
dc.date.available2017-01-10T16:21:12Z
dc.date.issued2016-02en
dc.identifier.urihttp://hdl.handle.net/10026.1/8231
dc.description.abstract

OBJECTIVES: To determine the effects of various monomers on conversion and cytocompatibility of dental composites and to improve these properties without detrimentally affecting mechanical properties, depth of cure and shrinkage. METHODS: Composites containing urethane dimethacrylate (UDMA) or bisphenol A glycidyl methacrylate (Bis-GMA) with poly(propylene glycol) dimethacrylate (PPGDMA) or triethylene glycol dimethacrylate (TEGDMA) were characterized using the following techniques: conversion (FTIR at 1 and 4mm depths), depth of cure (BS EN ISO 4049:2009 and FTIR), shrinkage (BS EN ISO 17304:2013 and FTIR), strength and modulus (biaxial flexural test) and water sorption. Cytocompatibility of composites and their liquid phase components was assessed using three assays (resazurin, WST-8 and MTS). RESULTS: UDMA significantly improved conversion, BFS and depth of cure compared to Bis-GMA, without increasing shrinkage. UDMA was cytotoxic at lower concentrations than Bis-GMA, but extracts of Bis-GMA-containing composites were less cytocompatible than of those containing UDMA. PPGDMA improved conversion and depth of cure compared to TEGDMA, without detrimentally affecting shrinkage. TEGDMA was shown by all assays to be highly toxic. Resazurin, but not WST-8 and MTS, suggested that PPGDMA exhibited improved cytocompatibility compared to TEGDMA. SIGNIFICANCE: The use of UDMA and PPGDMA results in composites with excellent conversion, depth of cure and mechanical properties, without increasing shrinkage. Composites containing UDMA appear to be slightly more cytocompatible than those containing Bis-GMA. These monomers may therefore improve the material properties of dental restorations, particularly bulk fill materials. The effect of diluent monomer on cytocompatibility requires further investigation.

en
dc.format.extent264 - 277en
dc.languageengen
dc.language.isoengen
dc.relation.replaceshttp://hdl.handle.net/10026.1/8228
dc.relation.replaces10026.1/8228
dc.subjectBis-GMAen
dc.subjectCytocompatibilityen
dc.subjectDegree of conversionen
dc.subjectDental compositeen
dc.subjectDental materialen
dc.subjectMonomeren
dc.subjectPPGDMAen
dc.subjectPolymerization shrinkageen
dc.subjectTEGDMAen
dc.subjectUDMAen
dc.subjectBiocompatible Materialsen
dc.subjectBisphenol A-Glycidyl Methacrylateen
dc.subjectComposite Resinsen
dc.subjectElastic Modulusen
dc.subjectLight-Curing of Dental Adhesivesen
dc.subjectMaterials Testingen
dc.subjectMethacrylatesen
dc.subjectPhase Transitionen
dc.subjectPolyethylene Glycolsen
dc.subjectPolymerizationen
dc.subjectPolymethacrylic Acidsen
dc.subjectPolyurethanesen
dc.subjectPropylene Glycolen
dc.subjectSurface Propertiesen
dc.subjectTensile Strengthen
dc.titlePoly(propylene glycol) and urethane dimethacrylates improve conversion of dental composites and reveal complexity of cytocompatibility testing.en
dc.typeJournal Article
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/26764174en
plymouth.issue2en
plymouth.volume32en
plymouth.publication-statusPublisheden
plymouth.journalDent Materen
dc.identifier.doi10.1016/j.dental.2015.11.017en
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/00 Groups by role
plymouth.organisational-group/Plymouth/00 Groups by role/Academics
plymouth.organisational-group/Plymouth/Faculty of Medicine and Dentistry
plymouth.organisational-group/Plymouth/Faculty of Medicine and Dentistry/Biomedical Research Group
plymouth.organisational-group/Plymouth/Faculty of Medicine and Dentistry/Biomedical Research Group/RC Reporting Group BRG
plymouth.organisational-group/Plymouth/Faculty of Medicine and Dentistry/Peninsula Dental School
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CBR
dc.publisher.placeEnglanden
dcterms.dateAccepted2015-11-30en
dc.identifier.eissn1879-0097en
dc.rights.embargoperiodNo embargoen
rioxxterms.versionofrecord10.1016/j.dental.2015.11.017en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2016-02en
rioxxterms.typeJournal Article/Reviewen


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