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dc.contributor.authorWalters, NJ
dc.contributor.authorXia, W
dc.contributor.authorSalih, V
dc.contributor.authorAshley, PF
dc.contributor.authorYoung, AM
dc.date.accessioned2017-01-10T15:55:41Z
dc.date.accessioned2017-01-10T16:21:12Z
dc.date.available2017-01-10T15:55:41Z
dc.date.available2017-01-10T16:21:12Z
dc.date.issued2016-02
dc.identifier.issn0109-5641
dc.identifier.issn1879-0097
dc.identifier.urihttp://hdl.handle.net/10026.1/8231
dc.description.abstract

OBJECTIVES: To determine the effects of various monomers on conversion and cytocompatibility of dental composites and to improve these properties without detrimentally affecting mechanical properties, depth of cure and shrinkage. METHODS: Composites containing urethane dimethacrylate (UDMA) or bisphenol A glycidyl methacrylate (Bis-GMA) with poly(propylene glycol) dimethacrylate (PPGDMA) or triethylene glycol dimethacrylate (TEGDMA) were characterized using the following techniques: conversion (FTIR at 1 and 4mm depths), depth of cure (BS EN ISO 4049:2009 and FTIR), shrinkage (BS EN ISO 17304:2013 and FTIR), strength and modulus (biaxial flexural test) and water sorption. Cytocompatibility of composites and their liquid phase components was assessed using three assays (resazurin, WST-8 and MTS). RESULTS: UDMA significantly improved conversion, BFS and depth of cure compared to Bis-GMA, without increasing shrinkage. UDMA was cytotoxic at lower concentrations than Bis-GMA, but extracts of Bis-GMA-containing composites were less cytocompatible than of those containing UDMA. PPGDMA improved conversion and depth of cure compared to TEGDMA, without detrimentally affecting shrinkage. TEGDMA was shown by all assays to be highly toxic. Resazurin, but not WST-8 and MTS, suggested that PPGDMA exhibited improved cytocompatibility compared to TEGDMA. SIGNIFICANCE: The use of UDMA and PPGDMA results in composites with excellent conversion, depth of cure and mechanical properties, without increasing shrinkage. Composites containing UDMA appear to be slightly more cytocompatible than those containing Bis-GMA. These monomers may therefore improve the material properties of dental restorations, particularly bulk fill materials. The effect of diluent monomer on cytocompatibility requires further investigation.

dc.format.extent264-277
dc.format.mediumPrint-Electronic
dc.languageen
dc.language.isoeng
dc.publisherElsevier BV
dc.relation.replaceshttp://hdl.handle.net/10026.1/8228
dc.relation.replaces10026.1/8228
dc.subjectDental composite
dc.subjectDental material
dc.subjectMonomer
dc.subjectCytocompatibility
dc.subjectDegree of conversion
dc.subjectPolymerization shrinkage
dc.subjectPPGDMA
dc.subjectTEGDMA
dc.subjectUDMA
dc.subjectBis-GMA
dc.titlePoly(propylene glycol) and urethane dimethacrylates improve conversion of dental composites and reveal complexity of cytocompatibility testing
dc.typejournal-article
dc.typeArticle
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/26764174
plymouth.issue2
plymouth.volume32
plymouth.publisher-urlhttp://dx.doi.org/10.1016/j.dental.2015.11.017
plymouth.publication-statusPublished
plymouth.journalDental Materials
dc.identifier.doi10.1016/j.dental.2015.11.017
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Faculty of Health/Peninsula Dental School
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CBR
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
dc.publisher.placeEngland
dcterms.dateAccepted2015-11-30
dc.identifier.eissn1879-0097
dc.rights.embargoperiodNo embargo
rioxxterms.funderEngineering and Physical Sciences Research Council
rioxxterms.identifier.projectRe-mineralising, antibacterial composites and adhesives for more durable, conservative and pain less tooth restoration
rioxxterms.versionofrecord10.1016/j.dental.2015.11.017
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2016-02
rioxxterms.typeJournal Article/Review
plymouth.funderRe-mineralising, antibacterial composites and adhesives for more durable, conservative and pain less tooth restoration::Engineering and Physical Sciences Research Council


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