A surprisingly poor correlation between in vitro and in vivo testing of biomaterials for bone regeneration: results of a multicentre analysis
dc.contributor.author | Hulsart-Billström, G | |
dc.contributor.author | Dawson, JI | |
dc.contributor.author | Hofmann, S | |
dc.contributor.author | Müller, R | |
dc.contributor.author | Stoddart, MJ | |
dc.contributor.author | Alini, M | |
dc.contributor.author | Redl, R | |
dc.contributor.author | El Haj, A | |
dc.contributor.author | Brown, R | |
dc.contributor.author | Hagen, Chris | |
dc.contributor.author | Hilborn, J | |
dc.contributor.author | Larsson, S | |
dc.contributor.author | Oreffo, ROC | |
dc.date.accessioned | 2017-01-10T15:56:25Z | |
dc.date.available | 2017-01-10T15:56:25Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 1473-2262 | |
dc.identifier.issn | 1473-2262 | |
dc.identifier.uri | http://hdl.handle.net/10026.1/8229 | |
dc.description.abstract |
New regenerative materials and approaches need to be assessed through reliable and comparable methods for rapid translation to the clinic. There is a considerable need for proven in vitro assays that are able to reduce the burden on animal testing, by allowing assessment of biomaterial utility predictive of the results currently obtained through in vivo studies. The purpose of this multicentre review was to investigate the correlation between existing in vitro results with in vivo outcomes observed for a range of biomaterials. Members from the European consortium BioDesign, comprising 8 universities in a European multicentre study, provided data from 36 in vivo studies and 47 in vitro assays testing 93 different biomaterials. The outcomes of the in vitro and in vivo experiments were scored according to commonly recognised measures of success relevant to each experiment. The correlation of in vitro with in vivo scores for each assay alone and in combination was assessed. A surprisingly poor correlation between in vitro and in vivo assessments of biomaterials was revealed indicating a clear need for further development of relevant in vitro assays. There was no significant overall correlation between in vitro and in vivo outcome. The mean in vitro scores revealed a trend of covariance to in vivo score with 58 %. The inadequacies of the current in vitro assessments highlighted here further stress the need for the development of novel approaches to in vitro biomaterial testing and validated pre-clinical pipelines. | |
dc.format.extent | 312-322 | |
dc.format.medium | Electronic | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | European Cells and Materials | |
dc.subject | in vivo | |
dc.subject | in vitro | |
dc.subject | correlation | |
dc.subject | biomaterials | |
dc.subject | multicentre study | |
dc.title | A surprisingly poor correlation between in vitro and in vivo testing of biomaterials for bone regeneration: results of a multicentre analysis | |
dc.type | journal-article | |
dc.type | Journal Article | |
dc.type | Multicenter Study | |
dc.type | Research Support, Non-U.S. Gov't | |
plymouth.author-url | https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000384895100020&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008 | |
plymouth.volume | 31 | |
plymouth.publication-status | Published online | |
plymouth.journal | European Cells and Materials | |
dc.identifier.doi | 10.22203/ecm.v031a20 | |
plymouth.organisational-group | /Plymouth | |
plymouth.organisational-group | /Plymouth/Faculty of Health | |
plymouth.organisational-group | /Plymouth/Faculty of Health/Peninsula Dental School | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy | |
plymouth.organisational-group | /Plymouth/Research Groups | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED) | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CBR | |
plymouth.organisational-group | /Plymouth/Users by role | |
plymouth.organisational-group | /Plymouth/Users by role/Academics | |
dc.publisher.place | Switzerland | |
dc.identifier.eissn | 1473-2262 | |
dc.rights.embargoperiod | No embargo | |
rioxxterms.versionofrecord | 10.22203/ecm.v031a20 | |
rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
rioxxterms.type | Journal Article/Review |