Sedation protocols to reduce duration of mechanical ventilation in the ICU: a Cochrane Systematic Review.
dc.contributor.author | Aitken, LM | |
dc.contributor.author | Bucknall, T | |
dc.contributor.author | Kent, B | |
dc.contributor.author | Mitchell, M | |
dc.contributor.author | Burmeister, E | |
dc.contributor.author | Keogh, S | |
dc.date.accessioned | 2016-12-16T18:25:53Z | |
dc.date.issued | 2016-02 | |
dc.identifier.issn | 0309-2402 | |
dc.identifier.issn | 1365-2648 | |
dc.identifier.uri | http://hdl.handle.net/10026.1/8138 | |
dc.description.abstract |
Assess the effects of protocol-directed sedation management on the duration of mechanical ventilation and other relevant patient outcomes in mechanically ventilated intensive care unit patients.Sedation is a core component of critical care. Sub-optimal sedation management incorporates both under- and over-sedation and has been linked to poorer patient outcomes.Cochrane systematic review of randomized controlled trials.Cochrane Central Register of Controlled trials, MEDLINE, EMBASE, CINAHL, Database of Abstracts of Reviews of Effects, LILACS, Current Controlled Trials and US National Institutes of Health Clinical Research Studies (1990-November 2013) and reference lists of articles were used.Randomized controlled trials conducted in intensive care units comparing management with and without protocol-directed sedation were included. Two authors screened titles, abstracts and full-text reports. Potential risk of bias was assessed. Clinical, methodological and statistical heterogeneity were examined and the random-effects model used for meta-analysis where appropriate. Mean difference for duration of mechanical ventilation and risk ratio for mortality, with 95% confidence intervals, were calculated.Two eligible studies with 633 participants comparing protocol-directed sedation delivered by nurses vs. usual care were identified. There was no evidence of differences in duration of mechanical ventilation or hospital mortality. There was statistically significant heterogeneity between studies for duration of mechanical ventilation.There is insufficient evidence to evaluate the effectiveness of protocol-directed sedation as results from the two randomized controlled trials were conflicting. | |
dc.format.extent | 261-272 | |
dc.format.medium | Print-Electronic | |
dc.language | en | |
dc.language.iso | en | |
dc.publisher | Wiley | |
dc.subject | critical care | |
dc.subject | evidence-based practice | |
dc.subject | sedation | |
dc.subject | systematic reviews and meta-analyses | |
dc.title | Sedation protocols to reduce duration of mechanical ventilation in the ICU: a Cochrane Systematic Review. | |
dc.type | journal-article | |
dc.type | Comparative Study | |
dc.type | Journal Article | |
dc.type | Research Support, Non-U.S. Gov't | |
dc.type | Systematic Review | |
plymouth.author-url | https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000367947700003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008 | |
plymouth.issue | 2 | |
plymouth.volume | 72 | |
plymouth.publication-status | Published | |
plymouth.journal | Journal of advanced nursing | |
dc.identifier.doi | 10.1111/jan.12843 | |
plymouth.organisational-group | /Plymouth | |
plymouth.organisational-group | /Plymouth/Faculty of Health | |
plymouth.organisational-group | /Plymouth/Faculty of Health/School of Nursing and Midwifery | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy | |
plymouth.organisational-group | /Plymouth/Research Groups | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Health and Community | |
plymouth.organisational-group | /Plymouth/Research Groups/Plymouth Institute of Health and Care Research (PIHR) | |
plymouth.organisational-group | /Plymouth/Users by role | |
plymouth.organisational-group | /Plymouth/Users by role/Academics | |
dc.publisher.place | England | |
dcterms.dateAccepted | 2015-09-15 | |
dc.rights.embargodate | 2017-2-1 | |
dc.identifier.eissn | 1365-2648 | |
dc.rights.embargoperiod | 6 months | |
rioxxterms.versionofrecord | 10.1111/jan.12843 | |
rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/under-embargo-all-rights-reserved | |
rioxxterms.licenseref.startdate | 2016-02 | |
rioxxterms.type | Journal Article/Review |