Impaired maturation of dendritic spines without disorganization of cortical cell layers in mice lacking NRG1/ErbB signaling in the central nervous system
dc.contributor.author | Barros, Claudia | |
dc.contributor.author | Calabrese, B | |
dc.contributor.author | Chamero, P | |
dc.contributor.author | Roberts, AJ | |
dc.contributor.author | Korzus, E | |
dc.contributor.author | Lloyd, K | |
dc.contributor.author | Stowers, L | |
dc.contributor.author | Mayford, M | |
dc.contributor.author | Halpain, S | |
dc.contributor.author | Müller, U | |
dc.date.accessioned | 2016-10-26T21:35:52Z | |
dc.date.available | 2016-10-26T21:35:52Z | |
dc.date.issued | 2009-03-17 | |
dc.identifier.issn | 0027-8424 | |
dc.identifier.issn | 1091-6490 | |
dc.identifier.uri | http://hdl.handle.net/10026.1/6648 | |
dc.description.abstract |
<jats:p> Neuregulin-1 (NRG1) and its ErbB2/B4 receptors are encoded by candidate susceptibility genes for schizophrenia, yet the essential functions of NRG1 signaling in the CNS are still unclear. Using CRE/LOX technology, we have inactivated ErbB2/B4-mediated NRG1 signaling specifically in the CNS. In contrast to expectations, cell layers in the cerebral cortex, hippocampus, and cerebellum develop normally in the mutant mice. Instead, loss of ErbB2/B4 impairs dendritic spine maturation and perturbs interactions of postsynaptic scaffold proteins with glutamate receptors. Conversely, increased NRG1 levels promote spine maturation. <jats:italic>ErbB2/B4</jats:italic> -deficient mice show increased aggression and reduced prepulse inhibition. Treatment with the antipsychotic drug clozapine reverses the behavioral and spine defects. We conclude that ErbB2/B4-mediated NRG1 signaling modulates dendritic spine maturation, and that defects at glutamatergic synapses likely contribute to the behavioral abnormalities in <jats:italic>ErbB2</jats:italic> / <jats:italic>B4</jats:italic> -deficient mice. </jats:p> | |
dc.format.extent | 4507-4512 | |
dc.format.medium | Print-Electronic | |
dc.language | en | |
dc.language.iso | eng | |
dc.publisher | Proceedings of the National Academy of Sciences | |
dc.subject | cerebral cortex | |
dc.subject | dendritic spines | |
dc.subject | migration | |
dc.subject | neuregulin | |
dc.subject | schizophrenia | |
dc.title | Impaired maturation of dendritic spines without disorganization of cortical cell layers in mice lacking NRG1/ErbB signaling in the central nervous system | |
dc.type | journal-article | |
dc.type | Journal Article | |
dc.type | Research Support, N.I.H., Extramural | |
dc.type | Research Support, Non-U.S. Gov't | |
plymouth.author-url | https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000264278800081&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008 | |
plymouth.issue | 11 | |
plymouth.volume | 106 | |
plymouth.publication-status | Published | |
plymouth.journal | Proceedings of the National Academy of Sciences | |
dc.identifier.doi | 10.1073/pnas.0900355106 | |
plymouth.organisational-group | /Plymouth | |
plymouth.organisational-group | /Plymouth/Faculty of Health | |
plymouth.organisational-group | /Plymouth/Faculty of Health/Peninsula Medical School | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine | |
plymouth.organisational-group | /Plymouth/Users by role | |
plymouth.organisational-group | /Plymouth/Users by role/Academics | |
plymouth.organisational-group | /Plymouth/Users by role/Researchers in ResearchFish submission | |
dc.publisher.place | United States | |
dc.identifier.eissn | 1091-6490 | |
dc.rights.embargoperiod | Not known | |
rioxxterms.versionofrecord | 10.1073/pnas.0900355106 | |
rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
rioxxterms.type | Journal Article/Review | |
plymouth.oa-location | http://www.pnas.org/content/106/11/4507.full.pdf?with-ds=yes |