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dc.contributor.authorSeverin, F
dc.contributor.authorBorry, P
dc.contributor.authorCornel, MC
dc.contributor.authorDaniels, N
dc.contributor.authorFellmann, F
dc.contributor.authorVictoria Hodgson, S
dc.contributor.authorHoward, HC
dc.contributor.authorJohn, J
dc.contributor.authorKääriäinen, H
dc.contributor.authorKayserili, H
dc.contributor.authorKent, A
dc.contributor.authorKoerber, F
dc.contributor.authorKristoffersson, U
dc.contributor.authorKroese, M
dc.contributor.authorLewis, C
dc.contributor.authorMarckmann, G
dc.contributor.authorMeyer, P
dc.contributor.authorPfeufer, A
dc.contributor.authorSchmidtke, J
dc.contributor.authorSkirton, Heather
dc.contributor.authorTranebjærg, L
dc.contributor.authorRogowski, WH
dc.date.accessioned2016-09-29T11:18:54Z
dc.date.available2016-09-29T11:18:54Z
dc.date.issued2015-06
dc.identifier.issn1018-4813
dc.identifier.issn1476-5438
dc.identifier.urihttp://hdl.handle.net/10026.1/5503
dc.description.abstract

Given the cost constraints of the European health-care systems, criteria are needed to decide which genetic services to fund from the public budgets, if not all can be covered. To ensure that high-priority services are available equitably within and across the European countries, a shared set of prioritization criteria would be desirable. A decision process following the accountability for reasonableness framework was undertaken, including a multidisciplinary EuroGentest/PPPC-ESHG workshop to develop shared prioritization criteria. Resources are currently too limited to fund all the beneficial genetic testing services available in the next decade. Ethically and economically reflected prioritization criteria are needed. Prioritization should be based on considerations of medical benefit, health need and costs. Medical benefit includes evidence of benefit in terms of clinical benefit, benefit of information for important life decisions, benefit for other people apart from the person tested and the patient-specific likelihood of being affected by the condition tested for. It may be subject to a finite time window. Health need includes the severity of the condition tested for and its progression at the time of testing. Further discussion and better evidence is needed before clearly defined recommendations can be made or a prioritization algorithm proposed. To our knowledge, this is the first time a clinical society has initiated a decision process about health-care prioritization on a European level, following the principles of accountability for reasonableness. We provide points to consider to stimulate this debate across the EU and to serve as a reference for improving patient management.

dc.format.extent729-735
dc.format.mediumPrint-Electronic
dc.languageen
dc.language.isoeng
dc.publisherSpringer Science and Business Media LLC
dc.subjectClinical Laboratory Services
dc.subjectConsensus
dc.subjectEurope
dc.subjectGenetic Testing
dc.subjectSocial Responsibility
dc.titlePoints to consider for prioritizing clinical genetic testing services: a European consensus process oriented at accountability for reasonableness
dc.typejournal-article
dc.typeJournal Article
dc.typeResearch Support, Non-U.S. Gov't
plymouth.author-urlhttps://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000354474600009&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008
plymouth.issue6
plymouth.volume23
plymouth.publication-statusPublished
plymouth.journalEuropean Journal of Human Genetics
dc.identifier.doi10.1038/ejhg.2014.190
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
dc.publisher.placeEngland
dcterms.dateAccepted2014-08-19
dc.identifier.eissn1476-5438
dc.rights.embargoperiodNot known
rioxxterms.versionofrecord10.1038/ejhg.2014.190
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2015-06
rioxxterms.typeJournal Article/Review


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