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dc.contributor.authorHanemann, CO
dc.contributor.authorBlakeley, JO
dc.contributor.authorNunes, FP
dc.contributor.authorRobertson, K
dc.contributor.authorStemmer-Rachamimov, A
dc.contributor.authorMautner, V
dc.contributor.authorKurtz, A
dc.contributor.authorFerguson, M
dc.contributor.authorWidemann, BC
dc.contributor.authorEvans, DG
dc.contributor.authorFerner, R
dc.contributor.authorCarroll, SL
dc.contributor.authorKorf, B
dc.contributor.authorWolkenstein, P
dc.contributor.authorKnight, P
dc.contributor.authorPlotkin, SR
dc.date.accessioned2016-09-14T16:48:46Z
dc.date.accessioned2016-09-27T10:40:25Z
dc.date.available2016-09-14T16:48:46Z
dc.date.issued2016-08-16
dc.identifier.issn0028-3878
dc.identifier.issn1526-632X
dc.identifier.urihttp://hdl.handle.net/10026.1/5488
dc.description.abstract

OBJECTIVE: Clinically validated biomarkers for neurofibromatosis 1 (NF1), neurofibromatosis 2 (NF2), and schwannomatosis (SWN) have not been identified to date. The biomarker working group's goals are to (1) define biomarker needs in NF1, NF2, and SWN; (2) summarize existing data on biomarkers in NF1, NF2, and SWN; (3) outline recommendations for sample collection and biomarker development; and (4) standardize sample collection and methodology protocols where possible to promote comparison between studies by publishing standard operating procedures (SOPs). METHODS: The biomarker group reviewed published data on biomarkers in NF1, NF2, and SWN and on biobanking efforts outside these diseases via literature search, defined the need for biomarkers in NF, and developed recommendations in a series of consensus meetings. RESULTS: We describe existing biomarkers in NF and report consensus recommendations for SOP and a minimal clinical dataset to accompany samples derived from patients with NF1, NF2, and SWN in decentralized biobanks. CONCLUSIONS: These recommendations are intended to provide clinicians and researchers with a common set of guidelines to collect and store biospecimens and for establishment of biobanks for NF1, NF2, and SWN.

dc.format.extentS40-S48
dc.format.mediumPrint
dc.languageen
dc.language.isoen
dc.publisherOvid Technologies (Wolters Kluwer Health)
dc.relation.replaceshttp://hdl.handle.net/10026.1/5445
dc.relation.replaces10026.1/5445
dc.subjectBiological Specimen Banks
dc.subjectBiomarkers
dc.subjectDatasets as Topic
dc.subjectHumans
dc.subjectNeurilemmoma
dc.subjectNeurofibromatoses
dc.subjectNeurofibromatosis 1
dc.subjectNeurofibromatosis 2
dc.subjectSkin Neoplasms
dc.titleCurrent status and recommendations for biomarkers and biobanking in neurofibromatosis
dc.typejournal-article
dc.typeArticle
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/27527649
plymouth.issue7 Supplement 1
plymouth.volume87
plymouth.publisher-urlhttp://dx.doi.org/10.1212/wnl.0000000000002932
plymouth.publication-statusPublished
plymouth.journalNeurology
dc.identifier.doi10.1212/WNL.0000000000002932
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Faculty of Health/Peninsula Medical School
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CBR
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
plymouth.organisational-group/Plymouth/Users by role/Researchers in ResearchFish submission
dc.publisher.placeUnited States
dcterms.dateAccepted2016-03-30
dc.identifier.eissn1526-632X
dc.rights.embargoperiodNot known
rioxxterms.versionofrecord10.1212/WNL.0000000000002932
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2016-08-16
rioxxterms.typeJournal Article/Review


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