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dc.contributor.authorSegaran, E
dc.contributor.authorWandrag, L
dc.contributor.authorStotz, M
dc.contributor.authorTerblanche, M
dc.contributor.authorHickson, Mary
dc.date.accessioned2016-08-25T16:48:24Z
dc.date.available2016-08-25T16:48:24Z
dc.date.issued2017-04
dc.identifier.issn0952-3871
dc.identifier.issn1365-277X
dc.identifier.urihttp://hdl.handle.net/10026.1/5382
dc.description.abstract

BACKGROUND: Critical illness is associated with muscle loss, weakness and poor recovery. The impact that illness and the ensuing metabolic response has on obese patients is not known. Objectives were to test if obese patients lose less muscle depth compared to non-obese patients; if a reduction in muscle depth was associated with reduced strength and recovery; and to assess the feasibility of these methods with a range of body mass index's (BMI). METHODS: A prospective observational pilot study of muscle depth in critically ill patients categorised by BMI was performed. Muscle depth changes were assessed by ultrasound on study days 1, 3, 5, 7, 12 and 14. Strength was measured via handgrip dynamometry and Medical Research Council (MRC) sum score on waking and at discharge from the intensive care unit. Level of dependency was measured with the Barthel index. RESULTS: 44 critically ill patients; 17 had normal BMI, 10 were overweight and 17 were obese. The three groups did not differ in baseline characteristics, except obese patients had significantly greater initial muscle depth. Muscle depth loss was similar between the BMI groups at each of the time points. Handgrip and MRC sum score were only possible in a small number of patients because of reduced alertness and weakness. Majority were deemed fully dependent based on the Barthel index. CONCLUSIONS: Obese patients lost muscle depth in a comparable manner to non-obese patients, suggesting that BMI may not prevent muscle depth loss. It was not possible to determine the effect on strength because the clinical condition of patients precluded reliable measurements.

dc.format.extent227-235
dc.format.mediumPrint-Electronic
dc.languageen
dc.language.isoen
dc.publisherWiley
dc.subjectcritical illness
dc.subjectintensive care
dc.subjectintensive care acquired weakness
dc.subjectmuscle wasting
dc.subjectnutrition support
dc.subjectobesity
dc.titleDoes body mass index impact on muscle wasting and recovery following critical illness? A pilot feasibility observational study
dc.typejournal-article
dc.typeJournal Article
dc.typeObservational Study
dc.typeResearch Support, Non-U.S. Gov't
plymouth.author-urlhttps://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000395560300011&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008
plymouth.issue2
plymouth.volume30
plymouth.publication-statusPublished
plymouth.journalJournal of Human Nutrition and Dietetics
dc.identifier.doi10.1111/jhn.12401
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Faculty of Health/School of Health Professions
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/Institute of Health and Community
plymouth.organisational-group/Plymouth/Research Groups/Plymouth Institute of Health and Care Research (PIHR)
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
dc.publisher.placeEngland
dcterms.dateAccepted2016-06-07
dc.rights.embargodate2017-8-1
dc.identifier.eissn1365-277X
dc.rights.embargoperiod12 months
rioxxterms.versionofrecord10.1111/jhn.12401
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/under-embargo-all-rights-reserved
rioxxterms.licenseref.startdate2017-04
rioxxterms.typeJournal Article/Review


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