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dc.contributor.authorHoang, PD
dc.contributor.authorBaysan, M
dc.contributor.authorGunn, Hilary
dc.contributor.authorCameron, M
dc.contributor.authorFreeman, Jennifer
dc.contributor.authorNitz, J
dc.contributor.authorLow Choy, NL
dc.contributor.authorLord, SR
dc.date.accessioned2016-08-24T13:41:25Z
dc.date.available2016-08-24T13:41:25Z
dc.date.issued2016-01-01
dc.identifier.issn2055-2173
dc.identifier.issn2055-2173
dc.identifier.urihttp://hdl.handle.net/10026.1/5366
dc.description.abstract

<jats:sec><jats:title>Introduction</jats:title><jats:p> The Physiological Profile Assessment (PPA) is used in research and clinical practice for assessing fall risk. We compared PPA test performance between people with multiple sclerosis (MS) and healthy controls, determined the fall-risk profile for people with MS and developed a reference database for people with MS. </jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p> For this study, 416 ambulant people with MS (51.5 ± 12.0 years) and 352 controls (52.8 ± 12.2 years) underwent the PPA (tests of contrast sensitivity, proprioception, quadriceps strength, reaction time and sway) with composite fall-risk scores computed from these measures. MS participants were followed prospectively for falls for 3 months. </jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p> The MS participants performed significantly worse than controls in each PPA test. The average composite fall-risk score was also significantly elevated, indicating a “marked” fall risk when compared with controls. In total, 155 MS participants (37.3%) reported 2 + falls in the follow-up period. Frequent fallers performed significantly worse than non-frequent fallers in the contrast sensitivity, reaction time and sway tests and had higher PPA composite scores. </jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p> In line with poor PPA test performances, falls incidence in people with MS was high. This study provides comprehensive reference data for the PPA measures for people with MS that could be used to inform future research and clinical practice. </jats:p></jats:sec>

dc.format.extent205521731664113-205521731664113
dc.format.mediumElectronic-eCollection
dc.languageen
dc.language.isoeng
dc.publisherSAGE Publications
dc.subjectMultiple sclerosis
dc.subjectepidemiology
dc.subjectoutcome measurement
dc.titleFall risk in people with MS: A Physiological Profile Assessment study
dc.typejournal-article
dc.typeJournal Article
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/28607722
plymouth.volume2
plymouth.publication-statusPublished
plymouth.journalMultiple Sclerosis Journal - Experimental, Translational and Clinical
dc.identifier.doi10.1177/2055217316641130
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Faculty of Health/School of Health Professions
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/Institute of Health and Community
plymouth.organisational-group/Plymouth/Research Groups/Plymouth Institute of Health and Care Research (PIHR)
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
plymouth.organisational-group/Plymouth/Users by role/Researchers in ResearchFish submission
dc.publisher.placeUnited States
dcterms.dateAccepted2016-03-02
dc.identifier.eissn2055-2173
dc.rights.embargoperiodNo embargo
rioxxterms.versionofrecord10.1177/2055217316641130
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2016-01
rioxxterms.typeJournal Article/Review


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