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dc.contributor.authorMasiero, Men
dc.contributor.authorSimões, FCen
dc.contributor.authorHan, HDen
dc.contributor.authorSnell, Cen
dc.contributor.authorPeterkin, Ten
dc.contributor.authorBridges, Een
dc.contributor.authorMangala, LSen
dc.contributor.authorWu, SY-Yen
dc.contributor.authorPradeep, Sen
dc.contributor.authorLi, Den
dc.contributor.authorHan, Cen
dc.contributor.authorDalton, Hen
dc.contributor.authorLopez-Berestein, Gen
dc.contributor.authorTuynman, JBen
dc.contributor.authorMortensen, Nen
dc.contributor.authorLi, J-Len
dc.contributor.authorPatient, Ren
dc.contributor.authorSood, AKen
dc.contributor.authorBanham, AHen
dc.contributor.authorHarris, ALen
dc.contributor.authorBuffa, FMen
dc.date.accessioned2016-08-09T15:05:33Z
dc.date.available2016-08-09T15:05:33Z
dc.date.issued2013-08-12en
dc.identifier.urihttp://hdl.handle.net/10026.1/5252
dc.description.abstract

Limited clinical benefits derived from anti-VEGF therapy have driven the identification of new targets involved in tumor angiogenesis. Here, we report an integrative meta-analysis to define the transcriptional program underlying angiogenesis in human cancer. This approach identified ELTD1, an orphan G-protein-coupled receptor whose expression is induced by VEGF/bFGF and repressed by DLL4 signaling. Extensive analysis of multiple cancer types demonstrates significant upregulation of ELTD1 in tumor-associated endothelial cells, with a higher expression correlating with favorable prognosis. Importantly, ELTD1 silencing impairs endothelial sprouting and vessel formation in vitro and in vivo, drastically reducing tumor growth and greatly improving survival. Collectively, these results provide insight into the regulation of tumor angiogenesis and highlight ELTD1 as key player in blood vessel formation.

en
dc.format.extent229 - 241en
dc.languageengen
dc.language.isoengen
dc.subjectAnimalsen
dc.subjectCell Growth Processesen
dc.subjectEndothelial Cellsen
dc.subjectFemaleen
dc.subjectGenetic Predisposition to Diseaseen
dc.subjectHCT116 Cellsen
dc.subjectHumansen
dc.subjectMiceen
dc.subjectMice, Nudeen
dc.subjectNeoplasmsen
dc.subjectNeovascularization, Pathologicen
dc.subjectReceptors, G-Protein-Coupleden
dc.subjectSignal Transductionen
dc.titleA core human primary tumor angiogenesis signature identifies the endothelial orphan receptor ELTD1 as a key regulator of angiogenesis.en
dc.typeJournal Article
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/23871637en
plymouth.issue2en
plymouth.volume24en
plymouth.publication-statusPublisheden
plymouth.journalCancer Cellen
dc.identifier.doi10.1016/j.ccr.2013.06.004en
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/00 Groups by role
plymouth.organisational-group/Plymouth/00 Groups by role/Academics
plymouth.organisational-group/Plymouth/Faculty of Medicine and Dentistry
plymouth.organisational-group/Plymouth/Faculty of Medicine and Dentistry/Biomedical Research Group
plymouth.organisational-group/Plymouth/Faculty of Medicine and Dentistry/Biomedical Research Group/RC Reporting Group BRG
plymouth.organisational-group/Plymouth/Faculty of Medicine and Dentistry/Collaboration for the Advancement of Medical Education Research Assessment
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine
dc.publisher.placeUnited Statesen
dcterms.dateAccepted2013-06-06en
dc.identifier.eissn1878-3686en
dc.rights.embargoperiodNot knownen
rioxxterms.versionofrecord10.1016/j.ccr.2013.06.004en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2013-08-12en
rioxxterms.typeJournal Article/Reviewen


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