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dc.contributor.authorZhao, Wen
dc.contributor.authorYin, Jen
dc.contributor.authorYang, Zen
dc.contributor.authorXie, Jen
dc.contributor.authorZhang, Yen
dc.contributor.authorXu, Wen
dc.contributor.authorLi, J-Len
dc.date.accessioned2016-08-09T14:50:43Z
dc.date.available2016-08-09T14:50:43Z
dc.date.issued2015-05en
dc.identifier.urihttp://hdl.handle.net/10026.1/5248
dc.description.abstract

OBJECTIVE: To define androgen insensitivity prevalence in hypospadias patients treated with preoperative hormone therapy. MATERIALS AND METHODS: We searched databases that were published in English and Chinese up to September 10, 2014 for our studies. Eligibility criteria were pre-established. Title, abstract, and full-text screenings were conducted by 2 authors independently. Discrepancies were resolved by consensus. Quality assessment of included studies was completed. Meta-analysis was done when appropriate using R, version 3.1.1 for Windows. Heterogeneity among individual studies was tested using the Cochran chi-square Q test and quantified by calculating the I(2) index. RESULTS: Thirteen of 1278 publications met inclusion criteria and were incorporated into this study. Of 306 patients with preoperative hormone therapy, 25 displayed androgen resistance. Meta-analysis demonstrated that the random-effects model generates a pooled estimate of 7.14% (95% confidence interval [CI], 3.16%-15.31%), whereas the fixed-effect model provides an estimate of 14.61% (95% CI, 10.00%-20.85%). Heterogeneity among included studies was found above medium (I(2) = 67.1% [95% CI, 41.2%-81.6%]; P = .0003]. After exclusion of the heterogeneity, both random-effects and fixed-effect models produce a consistent pooled estimate of 6.95% (95% CI, 0%-47.8%). CONCLUSION: We have defined that the prevalence of androgen resistance in hypospadias is 7.14% (95% CI, 3.16%-15.31%). To distinguish isolated hypospadias from patients with androgen insensitivity syndrome, we recommend that androgen-resistant patients should be specifically targeted by molecularly focused diagnosis. Management strategies should include identification of mutations in the androgen receptor gene, timely surgery to repair hypospadias, and long-term follow-up of sexual function and fertility later in life.

en
dc.format.extent1166 - 1172en
dc.languageengen
dc.language.isoengen
dc.subjectAndrogen-Insensitivity Syndromeen
dc.subjectChilden
dc.subjectChild, Preschoolen
dc.subjectChorionic Gonadotropinen
dc.subjectCombined Modality Therapyen
dc.subjectHumansen
dc.subjectHypospadiasen
dc.subjectInfanten
dc.subjectMaleen
dc.subjectPreoperative Careen
dc.subjectPrevalenceen
dc.subjectTestosteroneen
dc.titleMeta-analysis of Androgen Insensitivity in Preoperative Hormone Therapy in Hypospadias.en
dc.typeJournal Article
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/25805521en
plymouth.issue5en
plymouth.volume85en
plymouth.publication-statusPublisheden
plymouth.journalUrologyen
dc.identifier.doi10.1016/j.urology.2015.01.035en
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine/UoA01 Clinical Medicine
dc.publisher.placeUnited Statesen
dcterms.dateAccepted2015-01-27en
dc.identifier.eissn1527-9995en
dc.rights.embargoperiodNot knownen
rioxxterms.versionofrecord10.1016/j.urology.2015.01.035en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2015-05en
rioxxterms.typeJournal Article/Reviewen


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