Meta-analysis of Androgen Insensitivity in Preoperative Hormone Therapy in Hypospadias.
dc.contributor.author | Zhao, W | en |
dc.contributor.author | Yin, J | en |
dc.contributor.author | Yang, Z | en |
dc.contributor.author | Xie, J | en |
dc.contributor.author | Zhang, Y | en |
dc.contributor.author | Xu, W | en |
dc.contributor.author | Li, J-L | en |
dc.date.accessioned | 2016-08-09T14:50:43Z | |
dc.date.available | 2016-08-09T14:50:43Z | |
dc.date.issued | 2015-05 | en |
dc.identifier.uri | http://hdl.handle.net/10026.1/5248 | |
dc.description.abstract |
OBJECTIVE: To define androgen insensitivity prevalence in hypospadias patients treated with preoperative hormone therapy. MATERIALS AND METHODS: We searched databases that were published in English and Chinese up to September 10, 2014 for our studies. Eligibility criteria were pre-established. Title, abstract, and full-text screenings were conducted by 2 authors independently. Discrepancies were resolved by consensus. Quality assessment of included studies was completed. Meta-analysis was done when appropriate using R, version 3.1.1 for Windows. Heterogeneity among individual studies was tested using the Cochran chi-square Q test and quantified by calculating the I(2) index. RESULTS: Thirteen of 1278 publications met inclusion criteria and were incorporated into this study. Of 306 patients with preoperative hormone therapy, 25 displayed androgen resistance. Meta-analysis demonstrated that the random-effects model generates a pooled estimate of 7.14% (95% confidence interval [CI], 3.16%-15.31%), whereas the fixed-effect model provides an estimate of 14.61% (95% CI, 10.00%-20.85%). Heterogeneity among included studies was found above medium (I(2) = 67.1% [95% CI, 41.2%-81.6%]; P = .0003]. After exclusion of the heterogeneity, both random-effects and fixed-effect models produce a consistent pooled estimate of 6.95% (95% CI, 0%-47.8%). CONCLUSION: We have defined that the prevalence of androgen resistance in hypospadias is 7.14% (95% CI, 3.16%-15.31%). To distinguish isolated hypospadias from patients with androgen insensitivity syndrome, we recommend that androgen-resistant patients should be specifically targeted by molecularly focused diagnosis. Management strategies should include identification of mutations in the androgen receptor gene, timely surgery to repair hypospadias, and long-term follow-up of sexual function and fertility later in life. | en |
dc.format.extent | 1166 - 1172 | en |
dc.language | eng | en |
dc.language.iso | eng | en |
dc.subject | Androgen-Insensitivity Syndrome | en |
dc.subject | Child | en |
dc.subject | Child, Preschool | en |
dc.subject | Chorionic Gonadotropin | en |
dc.subject | Combined Modality Therapy | en |
dc.subject | Humans | en |
dc.subject | Hypospadias | en |
dc.subject | Infant | en |
dc.subject | Male | en |
dc.subject | Preoperative Care | en |
dc.subject | Prevalence | en |
dc.subject | Testosterone | en |
dc.title | Meta-analysis of Androgen Insensitivity in Preoperative Hormone Therapy in Hypospadias. | en |
dc.type | Journal Article | |
plymouth.author-url | https://www.ncbi.nlm.nih.gov/pubmed/25805521 | en |
plymouth.issue | 5 | en |
plymouth.volume | 85 | en |
plymouth.publication-status | Published | en |
plymouth.journal | Urology | en |
dc.identifier.doi | 10.1016/j.urology.2015.01.035 | en |
plymouth.organisational-group | /Plymouth | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine/UoA01 Clinical Medicine | |
dc.publisher.place | United States | en |
dcterms.dateAccepted | 2015-01-27 | en |
dc.identifier.eissn | 1527-9995 | en |
dc.rights.embargoperiod | Not known | en |
rioxxterms.versionofrecord | 10.1016/j.urology.2015.01.035 | en |
rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/all-rights-reserved | en |
rioxxterms.licenseref.startdate | 2015-05 | en |
rioxxterms.type | Journal Article/Review | en |