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dc.contributor.authorLong, Jen
dc.contributor.authorPan, Gen
dc.contributor.authorIfeachor, Een
dc.contributor.authorBelshaw, Ren
dc.contributor.authorLi, Xen
dc.date.accessioned2016-07-27T10:04:52Z
dc.date.available2016-07-27T10:04:52Z
dc.date.issued2016en
dc.identifier.urihttp://hdl.handle.net/10026.1/5119
dc.description.abstract

Blood-based biomarkers for Alzheimer's disease would be very valuable because blood is a more accessible biofluid and is suitable for repeated sampling. However, currently there are no robust and reliable blood-based biomarkers for practical diagnosis. In this study we used a knowledge-based protein feature pool and two novel support vector machine embedded feature selection methods to find panels consisting of two and three biomarkers. We validated these biomarker sets using another serum cohort and an RNA profile cohort from the brain. Our panels included the proteins ECH1, NHLRC2, HOXB7, FN1, ERBB2, and SLC6A13 and demonstrated promising sensitivity (>87%), specificity (>91%), and accuracy (>89%).

en
dc.format.extent4250480 - ?en
dc.languageengen
dc.language.isoengen
dc.subjectAlzheimer Diseaseen
dc.subjectBiomarkersen
dc.subjectBrainen
dc.subjectCarbon-Carbon Double Bond Isomerasesen
dc.subjectFibronectinsen
dc.subjectGABA Plasma Membrane Transport Proteinsen
dc.subjectHomeodomain Proteinsen
dc.subjectHumansen
dc.subjectKnowledge Basesen
dc.subjectProteomeen
dc.subjectRNA, Messengeren
dc.subjectReceptor, ErbB-2en
dc.subjectSensitivity and Specificityen
dc.subjectTranscriptomeen
dc.titleDiscovery of Novel Biomarkers for Alzheimer's Disease from Blood.en
dc.typeJournal Article
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/27418712en
plymouth.volume2016en
plymouth.publication-statusPublisheden
plymouth.journalDis Markersen
dc.identifier.doi10.1155/2016/4250480en
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/00 Groups by role
plymouth.organisational-group/Plymouth/00 Groups by role/Academics
plymouth.organisational-group/Plymouth/00 Groups by role/Professional Services staff
plymouth.organisational-group/Plymouth/Faculty of Medicine and Dentistry
plymouth.organisational-group/Plymouth/Faculty of Medicine and Dentistry/Biomedical Research Group
plymouth.organisational-group/Plymouth/Faculty of Medicine and Dentistry/Biomedical Research Group/RC Reporting Group BRG
plymouth.organisational-group/Plymouth/Faculty of Medicine and Dentistry/Collaboration for the Advancement of Medical Education Research Assessment
plymouth.organisational-group/Plymouth/Faculty of Medicine and Dentistry/Neuroscience
plymouth.organisational-group/Plymouth/Faculty of Medicine and Dentistry/School of Biomedical Sciences
plymouth.organisational-group/Plymouth/Faculty of Science and Engineering
plymouth.organisational-group/Plymouth/Faculty of Science and Engineering/School of Computing, Electronics and Mathematics
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA12 Engineering
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CBBB
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CBR
dc.publisher.placeUnited Statesen
dcterms.dateAccepted2016-05-04en
dc.identifier.eissn1875-8630en
dc.rights.embargoperiodNot knownen
rioxxterms.funderEPSRC
rioxxterms.identifier.projectNovel Point-of-Care Diagnostic Techniques for Dementia
rioxxterms.versionofrecord10.1155/2016/4250480en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2016en
rioxxterms.typeJournal Article/Reviewen
plymouth.funderNovel Point-of-Care Diagnostic Techniques for Dementia::EPSRCen
rioxxterms.funder.project961d416c-7c19-4617-8a9c-08d9a525fcde


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