Discovery of Novel Biomarkers for Alzheimer's Disease from Blood
dc.contributor.author | Long, J | |
dc.contributor.author | Pan, Genhua | |
dc.contributor.author | Ifeachor, Emmanuel | |
dc.contributor.author | Belshaw, Robert | |
dc.contributor.author | khazaeli, Shahab | |
dc.date.accessioned | 2016-07-27T10:04:52Z | |
dc.date.available | 2016-07-27T10:04:52Z | |
dc.date.issued | 2016-05-29 | |
dc.identifier.issn | 0278-0240 | |
dc.identifier.issn | 1875-8630 | |
dc.identifier.other | 4250480 | |
dc.identifier.uri | http://hdl.handle.net/10026.1/5119 | |
dc.description.abstract |
<jats:p>Blood-based biomarkers for Alzheimer’s disease would be very valuable because blood is a more accessible biofluid and is suitable for repeated sampling. However, currently there are no robust and reliable blood-based biomarkers for practical diagnosis. In this study we used a knowledge-based protein feature pool and two novel support vector machine embedded feature selection methods to find panels consisting of two and three biomarkers. We validated these biomarker sets using another serum cohort and an RNA profile cohort from the brain. Our panels included the proteins ECH1, NHLRC2, HOXB7, FN1, ERBB2, and SLC6A13 and demonstrated promising sensitivity (>87%), specificity (>91%), and accuracy (>89%).</jats:p> | |
dc.format.extent | 0-0 | |
dc.format.medium | Print-Electronic | |
dc.language | en | |
dc.language.iso | en | |
dc.publisher | Hindawi Limited | |
dc.subject | Alzheimer Disease | |
dc.subject | Biomarkers | |
dc.subject | Brain | |
dc.subject | Carbon-Carbon Double Bond Isomerases | |
dc.subject | Fibronectins | |
dc.subject | GABA Plasma Membrane Transport Proteins | |
dc.subject | Homeodomain Proteins | |
dc.subject | Humans | |
dc.subject | Knowledge Bases | |
dc.subject | Proteome | |
dc.subject | RNA, Messenger | |
dc.subject | Receptor, ErbB-2 | |
dc.subject | Sensitivity and Specificity | |
dc.subject | Transcriptome | |
dc.title | Discovery of Novel Biomarkers for Alzheimer's Disease from Blood | |
dc.type | journal-article | |
dc.type | Journal Article | |
plymouth.author-url | https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000379953900001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008 | |
plymouth.volume | 2016 | |
plymouth.publication-status | Published | |
plymouth.journal | Disease Markers | |
dc.identifier.doi | 10.1155/2016/4250480 | |
plymouth.organisational-group | /Plymouth | |
plymouth.organisational-group | /Plymouth/Faculty of Health | |
plymouth.organisational-group | /Plymouth/Faculty of Science and Engineering | |
plymouth.organisational-group | /Plymouth/Faculty of Science and Engineering/School of Engineering, Computing and Mathematics | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine/UoA01 Clinical Medicine | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA12 Engineering | |
plymouth.organisational-group | /Plymouth/Research Groups | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED) | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CBBB | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CBR | |
plymouth.organisational-group | /Plymouth/Users by role | |
plymouth.organisational-group | /Plymouth/Users by role/Academics | |
plymouth.organisational-group | /Plymouth/Users by role/Researchers in ResearchFish submission | |
dc.publisher.place | United States | |
dcterms.dateAccepted | 2016-05-04 | |
dc.identifier.eissn | 1875-8630 | |
dc.rights.embargoperiod | Not known | |
rioxxterms.funder | EPSRC | |
rioxxterms.identifier.project | Novel Point-of-Care Diagnostic Techniques for Dementia | |
rioxxterms.versionofrecord | 10.1155/2016/4250480 | |
rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
rioxxterms.licenseref.startdate | 2016-05-29 | |
rioxxterms.type | Journal Article/Review | |
plymouth.funder | Novel Point-of-Care Diagnostic Techniques for Dementia::EPSRC |