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dc.contributor.authorLong, J
dc.contributor.authorPan, G
dc.contributor.authorIfeachor, E
dc.contributor.authorBelshaw, R
dc.contributor.authorLi, X
dc.date.accessioned2016-07-27T10:04:52Z
dc.date.available2016-07-27T10:04:52Z
dc.date.issued2016-05-29
dc.identifier.issn0278-0240
dc.identifier.issn1875-8630
dc.identifier.other4250480
dc.identifier.urihttp://hdl.handle.net/10026.1/5119
dc.description.abstract

<jats:p>Blood-based biomarkers for Alzheimer’s disease would be very valuable because blood is a more accessible biofluid and is suitable for repeated sampling. However, currently there are no robust and reliable blood-based biomarkers for practical diagnosis. In this study we used a knowledge-based protein feature pool and two novel support vector machine embedded feature selection methods to find panels consisting of two and three biomarkers. We validated these biomarker sets using another serum cohort and an RNA profile cohort from the brain. Our panels included the proteins ECH1, NHLRC2, HOXB7, FN1, ERBB2, and SLC6A13 and demonstrated promising sensitivity (&gt;87%), specificity (&gt;91%), and accuracy (&gt;89%).</jats:p>

dc.format.extent0-0
dc.format.mediumPrint-Electronic
dc.languageen
dc.language.isoen
dc.publisherHindawi Limited
dc.subjectAlzheimer Disease
dc.subjectBiomarkers
dc.subjectBrain
dc.subjectCarbon-Carbon Double Bond Isomerases
dc.subjectFibronectins
dc.subjectGABA Plasma Membrane Transport Proteins
dc.subjectHomeodomain Proteins
dc.subjectHumans
dc.subjectKnowledge Bases
dc.subjectProteome
dc.subjectRNA, Messenger
dc.subjectReceptor, ErbB-2
dc.subjectSensitivity and Specificity
dc.subjectTranscriptome
dc.titleDiscovery of Novel Biomarkers for Alzheimer's Disease from Blood
dc.typejournal-article
dc.typeArticle
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/27418712
plymouth.volume2016
plymouth.publisher-urlhttp://dx.doi.org/10.1155/2016/4250480
plymouth.publication-statusPublished
plymouth.journalDisease Markers
dc.identifier.doi10.1155/2016/4250480
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Faculty of Science and Engineering
plymouth.organisational-group/Plymouth/Faculty of Science and Engineering/School of Engineering, Computing and Mathematics
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine/UoA01 Clinical Medicine
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA12 Engineering
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CBBB
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CBR
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
plymouth.organisational-group/Plymouth/Users by role/Researchers in ResearchFish submission
dc.publisher.placeUnited States
dcterms.dateAccepted2016-05-04
dc.identifier.eissn1875-8630
dc.rights.embargoperiodNot known
rioxxterms.funderEPSRC
rioxxterms.identifier.projectNovel Point-of-Care Diagnostic Techniques for Dementia
rioxxterms.versionofrecord10.1155/2016/4250480
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2016-05-29
rioxxterms.typeJournal Article/Review
plymouth.funderNovel Point-of-Care Diagnostic Techniques for Dementia::EPSRC


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