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dc.contributor.authorMcNeil, PLen
dc.contributor.authorBoyle, Den
dc.contributor.authorHenry, TBen
dc.contributor.authorHandy, RDen
dc.contributor.authorSloman, KAen
dc.date.accessioned2016-06-22T16:02:50Z
dc.date.available2016-06-22T16:02:50Z
dc.date.issued2014-07en
dc.identifier.urihttp://hdl.handle.net/10026.1/4946
dc.description.abstract

The unique physicochemistry and potential toxicity of manufactured nanoparticles (NPs) requires innovative approaches for the assessment of toxicity to aquatic organisms. Here, the toxicity of Cu-NPs, Ag-NPs and TiO2-NPs on the lateral line system of free-swimming zebrafish embryos was investigated and compared to appropriate metal salts or bulk material controls. Fish were exposed for 4h at 96-h post-fertilization. Metal salt (CuSO4 and AgNO3) controls reduced the number of functional lateral line neuromasts (LLN) to <5% of unexposed controls, but no effect on LLN was observed for TiO2-NPs or Ag-NPs. Exposure to Cu-NPs caused only a 15% reduction in LLN. Performance of positive rheotaxis was reduced by Cu-NPs, Ag-NPs, and the metal salt controls. The data show that some metal NPs can affect LLN and fish behaviour (rheotaxis) important for survival, and that effects were different from those of comparable metal ion controls. Capsule: We demonstrate that behaviour is a particularly sensitive indicator of metal NP exposure in fish and highlight the interaction between behaviour and external tissue surfaces.

en
dc.format.extent318 - 323en
dc.languageengen
dc.language.isoengen
dc.subjectCopperen
dc.subjectEmbryoen
dc.subjectNeuromasten
dc.subjectRheotaxisen
dc.subjectSilveren
dc.subjectTitaniumen
dc.subjectAnimalsen
dc.subjectBehavior, Animalen
dc.subjectEmbryo, Nonmammalianen
dc.subjectLateral Line Systemen
dc.subjectMetal Nanoparticlesen
dc.subjectWater Pollutants, Chemicalen
dc.subjectZebrafishen
dc.titleEffects of metal nanoparticles on the lateral line system and behaviour in early life stages of zebrafish (Danio rerio).en
dc.typeJournal Article
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/24813264en
plymouth.volume152en
plymouth.publication-statusPublisheden
plymouth.journalAquat Toxicolen
dc.identifier.doi10.1016/j.aquatox.2014.04.022en
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/00 Groups by role
plymouth.organisational-group/Plymouth/00 Groups by role/Academics
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA06 Agriculture, Veterinary and Food Science
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/Marine Institute
dc.publisher.placeNetherlandsen
dcterms.dateAccepted2014-04-19en
dc.identifier.eissn1879-1514en
dc.rights.embargoperiodNot knownen
rioxxterms.versionofrecord10.1016/j.aquatox.2014.04.022en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2014-07en
rioxxterms.typeJournal Article/Reviewen


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