Show simple item record

dc.contributor.authorBesinis, Aen
dc.contributor.authorDe Peralta, Ten
dc.contributor.authorTredwin, CJen
dc.contributor.authorHandy, RDen
dc.date.accessioned2016-06-22T15:58:00Z
dc.date.available2016-06-22T15:58:00Z
dc.date.issued2015-03-24en
dc.identifier.urihttp://hdl.handle.net/10026.1/4943
dc.description.abstract

Interest in the use of engineered nanomaterials (ENMs) as either nanomedicines or dental materials/devices in clinical dentistry is growing. This review aims to detail the ultrafine structure, chemical composition, and reactivity of dental tissues in the context of interactions with ENMs, including the saliva, pellicle layer, and oral biofilm; then describes the applications of ENMs in dentistry in context with beneficial clinical outcomes versus potential risks. The flow rate and quality of saliva are likely to influence the behavior of ENMs in the oral cavity, but how the protein corona formed on the ENMs will alter bioavailability, or interact with the structure and proteins of the pellicle layer, as well as microbes in the biofilm, remains unclear. The tooth enamel is a dense crystalline structure that is likely to act as a barrier to ENM penetration, but underlying dentinal tubules are not. Consequently, ENMs may be used to strengthen dentine or regenerate pulp tissue. ENMs have dental applications as antibacterials for infection control, as nanofillers to improve the mechanical and bioactive properties of restoration materials, and as novel coatings on dental implants. Dentifrices and some related personal care products are already available for oral health applications. Overall, the clinical benefits generally outweigh the hazards of using ENMs in the oral cavity, and the latter should not prevent the responsible innovation of nanotechnology in dentistry. However, the clinical safety regulations for dental materials have not been specifically updated for ENMs, and some guidance on occupational health for practitioners is also needed. Knowledge gaps for future research include the formation of protein corona in the oral cavity, ENM diffusion through clinically relevant biofilms, and mechanistic investigations on how ENMs strengthen the tooth structure.

en
dc.format.extent2255 - 2289en
dc.languageengen
dc.language.isoengen
dc.subjectantibacterial activityen
dc.subjectbiomaterialsen
dc.subjectcalcium hydroxyapatiteen
dc.subjectdental implantsen
dc.subjectdentineen
dc.subjectenamelen
dc.subjectinfection controlen
dc.subjectnanocompositesen
dc.subjectnanoparticlesen
dc.subjectprotein coronaen
dc.subjectpulp stem cells differentiationen
dc.subjecttooth chemistryen
dc.subjectAnimalsen
dc.subjectDentistryen
dc.subjectHumansen
dc.subjectMouthen
dc.subjectNanomedicineen
dc.subjectNanostructuresen
dc.subjectSalivaen
dc.subjectToothen
dc.titleReview of nanomaterials in dentistry: interactions with the oral microenvironment, clinical applications, hazards, and benefits.en
dc.typeJournal Article
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/25625290en
plymouth.issue3en
plymouth.volume9en
plymouth.publication-statusPublisheden
plymouth.journalACS Nanoen
dc.identifier.doi10.1021/nn505015een
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/00 Groups by role
plymouth.organisational-group/Plymouth/00 Groups by role/Academics
plymouth.organisational-group/Plymouth/Faculty of Medicine and Dentistry
plymouth.organisational-group/Plymouth/Faculty of Medicine and Dentistry/Peninsula Dental School
plymouth.organisational-group/Plymouth/Faculty of Science and Engineering
plymouth.organisational-group/Plymouth/Faculty of Science and Engineering/School of Biological and Marine Sciences
plymouth.organisational-group/Plymouth/Faculty of Science and Engineering/School of Engineering
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA06 Agriculture, Veterinary and Food Science
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA12 Engineering
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/Marine Institute
dc.publisher.placeUnited Statesen
dc.identifier.eissn1936-086Xen
dc.rights.embargoperiodNot knownen
rioxxterms.versionofrecord10.1021/nn505015een
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.typeJournal Article/Reviewen


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record


All items in PEARL are protected by copyright law.
Author manuscripts deposited to comply with open access mandates are made available in accordance with publisher policies. Please cite only the published version using the details provided on the item record or document. In the absence of an open licence (e.g. Creative Commons), permissions for further reuse of content should be sought from the publisher or author.
Theme by 
@mire NV