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dc.contributor.authorDusinska, Men
dc.contributor.authorBoland, Sen
dc.contributor.authorSaunders, Men
dc.contributor.authorJuillerat-Jeanneret, Len
dc.contributor.authorTran, Len
dc.contributor.authorPojana, Gen
dc.contributor.authorMarcomini, Aen
dc.contributor.authorVolkovova, Ken
dc.contributor.authorTulinska, Jen
dc.contributor.authorKnudsen, LEen
dc.contributor.authorGombau, Len
dc.contributor.authorWhelan, Men
dc.contributor.authorCollins, ARen
dc.contributor.authorMarano, Fen
dc.contributor.authorHousiadas, Cen
dc.contributor.authorBilanicova, Den
dc.contributor.authorHalamoda Kenzaoui, Ben
dc.contributor.authorCorreia Carreira, Sen
dc.contributor.authorMagdolenova, Zen
dc.contributor.authorFjellsbø, LMen
dc.contributor.authorHuk, Aen
dc.contributor.authorHandy, Ren
dc.contributor.authorWalker, Len
dc.contributor.authorBarancokova, Men
dc.contributor.authorBartonova, Aen
dc.contributor.authorBurello, Een
dc.contributor.authorCastell, Jen
dc.contributor.authorCowie, Hen
dc.contributor.authorDrlickova, Men
dc.contributor.authorGuadagnini, Ren
dc.contributor.authorHarris, Gen
dc.contributor.authorHarju, Men
dc.contributor.authorHeimstad, ESen
dc.contributor.authorHurbankova, Men
dc.contributor.authorKazimirova, Aen
dc.contributor.authorKovacikova, Zen
dc.contributor.authorKuricova, Men
dc.contributor.authorLiskova, Aen
dc.contributor.authorMilcamps, Aen
dc.contributor.authorNeubauerova, Een
dc.contributor.authorPalosaari, Ten
dc.contributor.authorPapazafiri, Pen
dc.contributor.authorPilou, Men
dc.contributor.authorPoulsen, MSen
dc.contributor.authorRoss, Ben
dc.contributor.authorRunden-Pran, Een
dc.contributor.authorSebekova, Ken
dc.contributor.authorStaruchova, Men
dc.contributor.authorVallotto, Den
dc.contributor.authorWorth, Aen
dc.date.accessioned2016-06-22T15:55:56Z
dc.date.available2016-06-22T15:55:56Z
dc.date.issued2015-05en
dc.identifier.urihttp://hdl.handle.net/10026.1/4942
dc.description.abstract

In spite of recent advances in describing the health outcomes of exposure to nanoparticles (NPs), it still remains unclear how exactly NPs interact with their cellular targets. Size, surface, mass, geometry, and composition may all play a beneficial role as well as causing toxicity. Concerns of scientists, politicians and the public about potential health hazards associated with NPs need to be answered. With the variety of exposure routes available, there is potential for NPs to reach every organ in the body but we know little about the impact this might have. The main objective of the FP7 NanoTEST project ( www.nanotest-fp7.eu ) was a better understanding of mechanisms of interactions of NPs employed in nanomedicine with cells, tissues and organs and to address critical issues relating to toxicity testing especially with respect to alternatives to tests on animals. Here we describe an approach towards alternative testing strategies for hazard and risk assessment of nanomaterials, highlighting the adaptation of standard methods demanded by the special physicochemical features of nanomaterials and bioavailability studies. The work has assessed a broad range of toxicity tests, cell models and NP types and concentrations taking into account the inherent impact of NP properties and the effects of changes in experimental conditions using well-characterized NPs. The results of the studies have been used to generate recommendations for a suitable and robust testing strategy which can be applied to new medical NPs as they are developed.

en
dc.format.extent118 - 132en
dc.languageengen
dc.language.isoengen
dc.subjectHazard assessmenten
dc.subjectNanoTESTen
dc.subjectin vitroen
dc.subjectnanoparticlesen
dc.subjecttesting strategyen
dc.subjectHumansen
dc.subjectIn Vitro Techniquesen
dc.subjectNanomedicineen
dc.subjectNanoparticlesen
dc.subjectToxicity Testsen
dc.titleTowards an alternative testing strategy for nanomaterials used in nanomedicine: lessons from NanoTEST.en
dc.typeJournal Article
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/25923349en
plymouth.volume9 Suppl 1en
plymouth.publication-statusPublisheden
plymouth.journalNanotoxicologyen
dc.identifier.doi10.3109/17435390.2014.991431en
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/00 Groups by role
plymouth.organisational-group/Plymouth/00 Groups by role/Academics
plymouth.organisational-group/Plymouth/Faculty of Science and Engineering
plymouth.organisational-group/Plymouth/Faculty of Science and Engineering/School of Biological and Marine Sciences
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA06 Agriculture, Veterinary and Food Science
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/Marine Institute
dc.publisher.placeEnglanden
dc.identifier.eissn1743-5404en
dc.rights.embargoperiodNot knownen
rioxxterms.versionofrecord10.3109/17435390.2014.991431en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.typeJournal Article/Reviewen


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