Activation of multiple growth factor signalling pathways is frequent in meningiomas
dc.contributor.author | Hilton, DA | |
dc.contributor.author | Shivane, A | |
dc.contributor.author | Kirk, L | |
dc.contributor.author | Bassiri, K | |
dc.contributor.author | Enki, Doyo Gragn | |
dc.contributor.author | Hanemann, Clemens Oliver | |
dc.date.accessioned | 2016-05-12T15:06:16Z | |
dc.date.issued | 2016-06 | |
dc.identifier.issn | 0919-6544 | |
dc.identifier.issn | 1440-1789 | |
dc.identifier.uri | http://hdl.handle.net/10026.1/4621 | |
dc.description.abstract |
<jats:p>A minority of meningiomas are difficult to treat with surgery or radiotherapy, and chemotherapeutic alternatives are limited. This study aims to better understand pathways that are active in meningiomas, in order to direct future treatment strategies. We investigated the expression and activation of multiple growth factor receptors, their ligands and downstream signalling pathways in 30 meningiomas using immunohistochemistry. Expression was correlated with chromosome 22q loss. Membrane expression of VEGF receptor (VEGFR) and platelet‐derived growth factor receptor (PDGFR)<jats:italic>β</jats:italic> was seen in 83% of tumors, Axl in 70%, EGFR in 50% and insulin‐like growth factor receptor in 47%. Expression was similar in low‐ and high‐grade tumors, but membrane EGFR expression was not seen in tumors showing chromosome 22q loss (<jats:italic>P</jats:italic> < 0.05). Expression of ligands (IGF, NRG, VEGF, Gas 6), and signalling proteins (Mek, Erk, Jnk, Akt) and pS6RP, was widespread. Western blot confirmed widespread Axl expression and supported selective expression of EGFR in <jats:italic>NF2</jats:italic>‐intact meningiomas. The majority of meningiomas express and show activation of multiple growth factor receptors and their signalling pathways, irrespective of tumor grade. In addition to previously reported receptors, Axl offers a new therapeutic target. The findings also suggest that anti‐EGFR based therapies may be less effective in meningiomas with 22q loss.</jats:p> | |
dc.format.extent | 250-261 | |
dc.language | en | |
dc.language.iso | en | |
dc.publisher | Wiley | |
dc.subject | growth factor | |
dc.subject | meningioma | |
dc.subject | merlin | |
dc.subject | NF2 gene | |
dc.subject | protein kinase | |
dc.title | Activation of multiple growth factor signalling pathways is frequent in meningiomas | |
dc.type | journal-article | |
dc.type | Article | |
plymouth.author-url | https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000377213500004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008 | |
plymouth.issue | 3 | |
plymouth.volume | 36 | |
plymouth.publication-status | Published | |
plymouth.journal | Neuropathology | |
dc.identifier.doi | 10.1111/neup.12266 | |
plymouth.organisational-group | /Plymouth | |
plymouth.organisational-group | /Plymouth/Faculty of Health | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy | |
plymouth.organisational-group | /Plymouth/Research Groups | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Health and Community | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED) | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CBBB | |
plymouth.organisational-group | /Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CBR | |
plymouth.organisational-group | /Plymouth/Users by role | |
plymouth.organisational-group | /Plymouth/Users by role/Academics | |
plymouth.organisational-group | /Plymouth/Users by role/Researchers in ResearchFish submission | |
dcterms.dateAccepted | 2015-09-26 | |
dc.rights.embargodate | 2017-06-01 | |
dc.identifier.eissn | 1440-1789 | |
dc.rights.embargoperiod | 12 months | |
rioxxterms.versionofrecord | 10.1111/neup.12266 | |
rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/under-embargo-all-rights-reserved | |
rioxxterms.licenseref.startdate | 2016-06 | |
rioxxterms.type | Journal Article/Review |