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dc.contributor.authorPetty, NK
dc.contributor.authorBen Zakour, NL
dc.contributor.authorStanton-Cook, M
dc.contributor.authorSkippington, E
dc.contributor.authorTotsika, M
dc.contributor.authorForde, BM
dc.contributor.authorPhan, M-D
dc.contributor.authorGomes Moriel, D
dc.contributor.authorPeters, KM
dc.contributor.authorDavies, M
dc.contributor.authorRogers, BA
dc.contributor.authorDougan, G
dc.contributor.authorRodriguez-Baño, J
dc.contributor.authorPascual, A
dc.contributor.authorPitout, JDD
dc.contributor.authorUpton, M
dc.contributor.authorPaterson, DL
dc.contributor.authorWalsh, TR
dc.contributor.authorSchembri, MA
dc.contributor.authorBeatson, SA
dc.date.accessioned2016-04-18T20:24:54Z
dc.date.available2016-04-18T20:24:54Z
dc.date.issued2014-04-15
dc.identifier.issn0027-8424
dc.identifier.issn1091-6490
dc.identifier.urihttp://hdl.handle.net/10026.1/4518
dc.description.abstract

<jats:title>Significance</jats:title> <jats:p> <jats:italic>Escherichia coli</jats:italic> sequence type 131 (ST131) is a globally disseminated multidrug-resistant clone associated with human urinary tract and bloodstream infections. Here, we have used genome sequencing to map the temporal and spatial relationship of a large collection of <jats:italic>E. coli</jats:italic> ST131 strains isolated from six distinct geographical regions across the world. We show that <jats:italic>E. coli</jats:italic> ST131 strains are distinct from other extraintestinal pathogenic <jats:italic>E. coli</jats:italic> and arose from a single progenitor strain prior to the year 2000. </jats:p>

dc.format.extent5694-5699
dc.format.mediumPrint-Electronic
dc.languageen
dc.language.isoeng
dc.publisherProceedings of the National Academy of Sciences
dc.subjectbacterial evolution
dc.subjectgenomics
dc.subjectphylogeography
dc.subjectgenomic epidemiology
dc.titleGlobal dissemination of a multidrug resistant <i>Escherichia coli</i> clone
dc.typejournal-article
dc.typeArticle
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/24706808
plymouth.issue15
plymouth.volume111
plymouth.publisher-urlhttp://dx.doi.org/10.1073/pnas.1322678111
plymouth.publication-statusPublished
plymouth.journalProceedings of the National Academy of Sciences
dc.identifier.doi10.1073/pnas.1322678111
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Faculty of Health/School of Biomedical Sciences
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CBR
plymouth.organisational-group/Plymouth/Research Groups/Plymouth Institute of Health and Care Research (PIHR)
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
plymouth.organisational-group/Plymouth/Users by role/Researchers in ResearchFish submission
dc.publisher.placeUnited States
dc.identifier.eissn1091-6490
dc.rights.embargoperiodNo embargo
rioxxterms.versionofrecord10.1073/pnas.1322678111
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.typeJournal Article/Review


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