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dc.contributor.authorMarzi, Aen
dc.contributor.authorMurphy, AAen
dc.contributor.authorFeldmann, Fen
dc.contributor.authorParkins, CJen
dc.contributor.authorHaddock, Een
dc.contributor.authorHanley, PWen
dc.contributor.authorEmery, MJen
dc.contributor.authorEngelmann, Fen
dc.contributor.authorMessaoudi, Ien
dc.contributor.authorFeldmann, Hen
dc.contributor.authorJarvis, MAen
dc.date.accessioned2016-04-04T13:51:55Z
dc.date.available2016-04-04T13:51:55Z
dc.date.issued2016-02-15en
dc.identifier.urihttp://hdl.handle.net/10026.1/4471
dc.description.abstract

Ebolaviruses pose significant public health problems due to their high lethality, unpredictable emergence, and localization to the poorest areas of the world. In addition to implementation of standard public health control procedures, a number of experimental human vaccines are being explored as a further means for outbreak control. Recombinant cytomegalovirus (CMV)-based vectors are a novel vaccine platform that have been shown to induce substantial levels of durable, but primarily T-cell-biased responses against the encoded heterologous target antigen. Herein, we demonstrate the ability of rhesus CMV (RhCMV) expressing Ebola virus (EBOV) glycoprotein (GP) to provide protective immunity to rhesus macaques against lethal EBOV challenge. Surprisingly, vaccination was associated with high levels of GP-specific antibodies, but with no detectable GP-directed cellular immunity.

en
dc.format.extent21674 - ?en
dc.languageengen
dc.language.isoengen
dc.subjectAnimalsen
dc.subjectAntibodies, Viralen
dc.subjectCytomegalovirusen
dc.subjectDisease Models, Animalen
dc.subjectDrug Carriersen
dc.subjectEbola Vaccinesen
dc.subjectFemaleen
dc.subjectHemorrhagic Fever, Ebolaen
dc.subjectMacaca mulattaen
dc.subjectMaleen
dc.subjectSurvival Analysisen
dc.subjectVaccines, Syntheticen
dc.subjectViral Envelope Proteinsen
dc.titleCytomegalovirus-based vaccine expressing Ebola virus glycoprotein protects nonhuman primates from Ebola virus infection.en
dc.typeJournal Article
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/26876974en
plymouth.volume6en
plymouth.publication-statusPublished onlineen
plymouth.journalSci Repen
dc.identifier.doi10.1038/srep21674en
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/00 Groups by role
plymouth.organisational-group/Plymouth/00 Groups by role/Academics
plymouth.organisational-group/Plymouth/Faculty of Medicine and Dentistry
plymouth.organisational-group/Plymouth/Faculty of Medicine and Dentistry/Biomedical Research Group
plymouth.organisational-group/Plymouth/Faculty of Medicine and Dentistry/Biomedical Research Group/RC Reporting Group BRG
plymouth.organisational-group/Plymouth/Faculty of Medicine and Dentistry/School of Biomedical Sciences
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA01 Clinical Medicine
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)
plymouth.organisational-group/Plymouth/Research Groups/Institute of Translational and Stratified Medicine (ITSMED)/CBR
dc.publisher.placeEnglanden
dcterms.dateAccepted2016-01-28en
dc.identifier.eissn2045-2322en
dc.rights.embargoperiodNot knownen
rioxxterms.versionofrecord10.1038/srep21674en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2016-02-15en
rioxxterms.typeJournal Article/Reviewen


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