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dc.contributor.authorBunn, LMen
dc.contributor.authorMarsden, JFen
dc.contributor.authorVoyce, DCen
dc.contributor.authorGiunti, Pen
dc.contributor.authorDay, BLen
dc.date.accessioned2016-01-06T13:33:51Z
dc.date.available2016-01-06T13:33:51Z
dc.date.issued2015-08en
dc.identifier.urihttp://hdl.handle.net/10026.1/4177
dc.description.abstract

BACKGROUND: We investigated whether balance impairments caused by cerebellar disease are associated with specific sensorimotor processing deficits that generalize across all sensory modalities. Experiments focused on the putative cerebellar functions of scaling and coordinate transformation of balance responses evoked by stimulation of single sensory channels. METHODS: Vestibular, visual, and proprioceptive sensory channels were stimulated in isolation using galvanic vestibular stimulation, moving visual scenery, and muscle vibration, respectively, in 16 subjects with spinocerebellar ataxia type 6 (SCA6) and 16 matched healthy controls. Two polarities of each stimulus type evoked postural responses of similar form in the forward and backward directions. Disease severity was assessed using the Scale for Assessment and Rating of Ataxia. RESULTS: Impaired balance of SCA6 subjects during unperturbed stance was reflected in faster than normal body sway (P = 0.009), which correlated with disease severity (r = 0.705, P < 0.001). Sensory perturbations revealed a sensorimotor processing abnormality that was specific to response scaling for the visual channel. This manifested as visually evoked postural responses that were approximately three times larger than normal (backward, P < 0.001; forward P = 0.005) and correlated with disease severity (r = 0.543, P = 0.03). Response direction and habituation properties were no different from controls for all three sensory modalities. CONCLUSION: Cerebellar degeneration disturbs the scaling of postural responses evoked by visual motion, possibly through disinhibition of extracerebellar visuomotor centers. The excessively high gain of the visuomotor channel without compensatory decreases in gains of other sensorimotor channels provides a potential mechanism for instability of the balance control system in cerebellar disease.

en
dc.format.extent1259 - 1266en
dc.languageengen
dc.language.isoengen
dc.subjectMotor controlen
dc.subjectbalanceen
dc.subjectcerebellumen
dc.subjectclinical neurophysiologyen
dc.subjectspinocerebellar ataxiaen
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAnthropometryen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectMotionen
dc.subjectPostural Balanceen
dc.subjectPostureen
dc.subjectSensation Disordersen
dc.subjectSeverity of Illness Indexen
dc.subjectSpinocerebellar Ataxiasen
dc.subjectStatistics as Topicen
dc.subjectVestibule, Labyrinthen
dc.titleSensorimotor processing for balance in spinocerebellar ataxia type 6.en
dc.typeJournal Article
plymouth.author-urlhttps://www.ncbi.nlm.nih.gov/pubmed/25879732en
plymouth.issue9en
plymouth.volume30en
plymouth.publication-statusPublisheden
plymouth.journalMov Disorden
dc.identifier.doi10.1002/mds.26227en
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/00 Groups by role
plymouth.organisational-group/Plymouth/00 Groups by role/Academics
plymouth.organisational-group/Plymouth/Faculty of Health and Human Sciences
plymouth.organisational-group/Plymouth/Faculty of Health and Human Sciences/School of Health Professions
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/Institute of Health and Community
dc.publisher.placeUnited Statesen
dcterms.dateAccepted2015-03-12en
dc.identifier.eissn1531-8257en
dc.rights.embargoperiodNot knownen
rioxxterms.versionofrecord10.1002/mds.26227en
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2015-08en
rioxxterms.typeJournal Article/Reviewen
plymouth.oa-locationhttp://onlinelibrary.wiley.com/doi/10.1002/mds.26227/abstracten


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