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dc.contributor.authorVyas, N
dc.contributor.authorTurner, Andrew
dc.contributor.authorSewell, G
dc.date.accessioned2015-10-26T16:52:28Z
dc.date.accessioned2015-10-27T16:09:22Z
dc.date.available2015-10-26T16:52:28Z
dc.date.available2015-10-27T16:09:22Z
dc.date.issued2014-09
dc.identifier.issn0048-9697
dc.identifier.issn1879-1026
dc.identifier.urihttp://hdl.handle.net/10026.1/3702
dc.description.abstract

Concentrations of the cytotoxic platinum-based anticancer drugs, as total Pt, have been measured over a three week period in one of the main drains and in the effluent of the oncology ward of a major UK hospital (Derriford, Plymouth). Concentrations of Pt were highly variable in both discharges, and ranged from about 0.02 to 140 μg L(-1) in the oncology effluent and from about 0.03 to 100 μg L(-1) in the main drain. A comparison of drug administration figures over the study period with an estimate of the quantity of Pt discharged through the drains suggests that about 22% of total Pt is emitted to the environment from the hospital with the remainder being discharged by treated patients in the wider community. Administration figures for the three Pt-based drugs used in the hospital (cisplatin, carboplatin and oxaliplatin) coupled with published measurements on the removal of the drugs by conventional sewage treatment allowed the concentrations of Pt arising from each drug to be predicted in recipient surface waters as a function of water flow rate. For conditions representative of the region under study, concentrations of total Pt between a few tens and in excess of 100 pg L(-1) are predicted, with the principal form of the metal occurring as carboplatin and its metabolites. Although predicted concentrations are below EMEA guidelines warranting further risk assessment, the presence of substances in surface waters that are potentially carcinogenic, mutagenic and teratogenic and yet whose environmental effects are not understood is cause for concern.

dc.format.extent324-329
dc.format.mediumPrint-Electronic
dc.languageen
dc.language.isoeng
dc.publisherElsevier BV
dc.relation.replaceshttp://hdl.handle.net/10026.1/3698
dc.relation.replaces10026.1/3698
dc.subjectPlatinum
dc.subjectCytotoxic drugs
dc.subjectMetabolites
dc.subjectHospital waste
dc.subjectEnvironmental concentrations
dc.titlePlatinum-based anticancer drugs in waste waters of a major UK hospital and predicted concentrations in recipient surface waters
dc.typejournal-article
dc.typeJournal Article
plymouth.author-urlhttps://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000340312000034&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=11bb513d99f797142bcfeffcc58ea008
plymouth.volume493
plymouth.publication-statusPublished
plymouth.journalScience of The Total Environment
dc.identifier.doi10.1016/j.scitotenv.2014.05.127
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Faculty of Science and Engineering
plymouth.organisational-group/Plymouth/Faculty of Science and Engineering/School of Geography, Earth and Environmental Sciences
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
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plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy/UoA03 Allied Health Professions, Dentistry, Nursing and Pharmacy MANUAL
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA07 Earth Systems and Environmental Sciences
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plymouth.organisational-group/Plymouth/Research Groups/Institute of Health and Community
plymouth.organisational-group/Plymouth/Research Groups/Marine Institute
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dc.publisher.placeNetherlands
dcterms.dateAccepted2014-05-27
dc.identifier.eissn1879-1026
dc.rights.embargoperiodNot known
rioxxterms.versionofrecord10.1016/j.scitotenv.2014.05.127
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2014-09-15
rioxxterms.typeJournal Article/Review


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