Synthetic Retinoid Interventions and Outcomes in People with Cancer or Potentially Malignant Disorders of the Upper Aerodigestive Tract: A Systematic Review and Meta-analysis
dc.contributor.author | Norman, Alyson | |
dc.contributor.author | Perry, R | |
dc.contributor.author | Ness, AR | |
dc.contributor.author | Prime, SS | |
dc.contributor.author | Cole-Hawkins, H | |
dc.contributor.author | Thomas, S | |
dc.date.accessioned | 2015-04-07T12:12:44Z | |
dc.date.accessioned | 2015-04-07T12:13:41Z | |
dc.date.available | 2015-04-07T12:12:44Z | |
dc.date.available | 2015-04-07T12:13:41Z | |
dc.date.issued | 2014-12-08 | |
dc.identifier.issn | 1752-2471 | |
dc.identifier.issn | 1752-248X | |
dc.identifier.other | DOI:10.1111/ors.12134 | |
dc.identifier.uri | http://hdl.handle.net/10026.1/3286 | |
dc.description | File replaced (incorrect version) on 29/7/2022 by KT (LDS). | |
dc.description.abstract |
Background & Aims: Retinoids may have a role in the chemoprevention of potentially malignant disorders of the upper aerodigestive tract. Therefore, we conducted a systematic review of randomised controlled trials to examine the effect of synthetic retinoid interventions in people with cancer or potentially malignant disorders of the upper digestive tract. Methods: We searched five electronic databases and reference lists to locate all eligible trials and analysed trial quality. Outcome measures were all-cause and cancer mortality, disease-free survival, second primary cancer, cancer and potentially malignant disorder recurrence and progression to cancer. Results of individual trials were combined by use of random-effects meta-analyses. Results & Conclusions: We identified 17 15 trials, eightnine in people with upper aerodigestive tract cancer and seven eight in people with potentially malignant disorders, respectively. The results provide little evidence that retinoids have a beneficial effect on disease-free survival (OR=0.74, 95% CI =0.51, 1.09), all cause mortality (OR = 1.28, 95% confidence interval [CI] =1.00 to 1.65), disease-free survival (OR=0.74, 95% CI =0.51, 1.09), recurrence of cancer (OR = 1.47, 95% CI = 0.95, 2.26), development of second primary cancers (OR = 0.96, 95% CI = 0.76, 1.20) or the progression to malignancy (OR = 0.69, 95% CIs = 0.22, 2.15). There was even a suggestion of harm for some outcomes. There was also a suggestion that retinoids may decrease the recurrence of potentially malignant disorders (OR = 0.22, 95% CIs = 0.03, 1.34). For now there is no evidence to support the use of retinoids in people with upper aerodigestive tract cancer. | |
dc.format.extent | 131-146 | |
dc.language | English | |
dc.language.iso | English | |
dc.publisher | British Association of Oral Surgeons | |
dc.relation.replaces | http://hdl.handle.net/10026.1/3285 | |
dc.relation.replaces | 10026.1/3285 | |
dc.subject | Brain Disorders | |
dc.subject | Clinical Trials and Supportive Activities | |
dc.subject | Cancer | |
dc.subject | Clinical Research | |
dc.subject | Prevention | |
dc.subject | Digestive Diseases | |
dc.subject | Cancer | |
dc.title | Synthetic Retinoid Interventions and Outcomes in People with Cancer or Potentially Malignant Disorders of the Upper Aerodigestive Tract: A Systematic Review and Meta-analysis | |
dc.type | journal-article | |
dc.type | Article | |
plymouth.edition | 2014 | |
plymouth.issue | 12 | |
plymouth.volume | 8 | |
plymouth.publication-status | Published | |
plymouth.journal | Oral Surgery | |
dc.identifier.doi | 10.1111/ors.12134 | |
plymouth.organisational-group | /Plymouth | |
plymouth.organisational-group | /Plymouth/Faculty of Health | |
plymouth.organisational-group | /Plymouth/Faculty of Health/School of Psychology | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA | |
plymouth.organisational-group | /Plymouth/REF 2021 Researchers by UoA/UoA04 Psychology, Psychiatry and Neuroscience | |
plymouth.organisational-group | /Plymouth/Research Groups | |
plymouth.organisational-group | /Plymouth/Research Groups/Centre for Brain, Cognition and Behaviour (CBCB) | |
plymouth.organisational-group | /Plymouth/Research Groups/Centre for Brain, Cognition and Behaviour (CBCB)/Behaviour | |
plymouth.organisational-group | /Plymouth/Users by role | |
plymouth.organisational-group | /Plymouth/Users by role/Academics | |
dc.publisher.place | UK | |
dc.identifier.eissn | 1752-248X | |
dc.rights.embargoperiod | Not known | |
rioxxterms.versionofrecord | 10.1111/ors.12134 | |
rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
rioxxterms.type | Journal Article/Review |