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dc.contributor.authorNorman, AL
dc.contributor.authorPerry, R
dc.contributor.authorNess, AR
dc.contributor.authorPrime, SS
dc.contributor.authorCole-Hawkins, H
dc.contributor.authorThomas, S
dc.date.accessioned2015-04-07T12:12:44Z
dc.date.accessioned2015-04-07T12:13:41Z
dc.date.available2015-04-07T12:12:44Z
dc.date.available2015-04-07T12:13:41Z
dc.date.issued2014-12-08
dc.identifier.issn1752-2471
dc.identifier.issn1752-248X
dc.identifier.otherDOI:10.1111/ors.12134
dc.identifier.urihttp://hdl.handle.net/10026.1/3286
dc.descriptionFile replaced (incorrect version) on 29/7/2022 by KT (LDS).
dc.description.abstract

Background & Aims: Retinoids may have a role in the chemoprevention of potentially malignant disorders of the upper aerodigestive tract. Therefore, we conducted a systematic review of randomised controlled trials to examine the effect of synthetic retinoid interventions in people with cancer or potentially malignant disorders of the upper digestive tract. Methods: We searched five electronic databases and reference lists to locate all eligible trials and analysed trial quality. Outcome measures were all-cause and cancer mortality, disease-free survival, second primary cancer, cancer and potentially malignant disorder recurrence and progression to cancer. Results of individual trials were combined by use of random-effects meta-analyses. Results & Conclusions: We identified 17 15 trials, eightnine in people with upper aerodigestive tract cancer and seven eight in people with potentially malignant disorders, respectively. The results provide little evidence that retinoids have a beneficial effect on disease-free survival (OR=0.74, 95% CI =0.51, 1.09), all cause mortality (OR = 1.28, 95% confidence interval [CI] =1.00 to 1.65), disease-free survival (OR=0.74, 95% CI =0.51, 1.09), recurrence of cancer (OR = 1.47, 95% CI = 0.95, 2.26), development of second primary cancers (OR = 0.96, 95% CI = 0.76, 1.20) or the progression to malignancy (OR = 0.69, 95% CIs = 0.22, 2.15). There was even a suggestion of harm for some outcomes. There was also a suggestion that retinoids may decrease the recurrence of potentially malignant disorders (OR = 0.22, 95% CIs = 0.03, 1.34). For now there is no evidence to support the use of retinoids in people with upper aerodigestive tract cancer.

dc.format.extent131-146
dc.languageEnglish
dc.language.isoEnglish
dc.publisherBritish Association of Oral Surgeons
dc.relation.replaceshttp://hdl.handle.net/10026.1/3285
dc.relation.replaces10026.1/3285
dc.subject32 Biomedical and Clinical Sciences
dc.subject3211 Oncology and Carcinogenesis
dc.subjectDigestive Diseases
dc.subjectClinical Research
dc.subjectPrevention
dc.subjectCancer
dc.subjectClinical Trials and Supportive Activities
dc.subjectBrain Disorders
dc.subjectCancer
dc.subject3 Good Health and Well Being
dc.titleSynthetic Retinoid Interventions and Outcomes in People with Cancer or Potentially Malignant Disorders of the Upper Aerodigestive Tract: A Systematic Review and Meta-analysis
dc.typejournal-article
dc.typeArticle
plymouth.edition2014
plymouth.issue12
plymouth.volume8
plymouth.publisher-urlhttp://dx.doi.org/10.1111/ors.12134
plymouth.publication-statusPublished
plymouth.journalOral Surgery
dc.identifier.doi10.1111/ors.12134
plymouth.organisational-group/Plymouth
plymouth.organisational-group/Plymouth/Faculty of Health
plymouth.organisational-group/Plymouth/Faculty of Health/School of Psychology
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA
plymouth.organisational-group/Plymouth/REF 2021 Researchers by UoA/UoA04 Psychology, Psychiatry and Neuroscience
plymouth.organisational-group/Plymouth/Research Groups
plymouth.organisational-group/Plymouth/Research Groups/Centre for Brain, Cognition and Behaviour (CBCB)
plymouth.organisational-group/Plymouth/Research Groups/Centre for Brain, Cognition and Behaviour (CBCB)/Behaviour
plymouth.organisational-group/Plymouth/Users by role
plymouth.organisational-group/Plymouth/Users by role/Academics
dc.publisher.placeUK
dc.identifier.eissn1752-248X
dc.rights.embargoperiodNot known
rioxxterms.versionofrecord10.1111/ors.12134
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.typeJournal Article/Review


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